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Physiol."],"abstract":"<jats:p>Circadian rhythm disturbances are the most common symptoms during the early onset of AD. Circadian rhythm disorders aggravate the deposition of amyloid plaques in the brains of AD patients. Therefore, improving the circadian rhythm of AD patients might slow down the pathological development of neurodegeneration. Circadian regulation is driven by a master clock in suprachiasmatic nuclei (SCN) and peripheral clock located in peripheral organs. The rhythmic feeding\u2013fasting cycle has been proved to dominant cue to entrain peripheral clocks. We hypothesized that dietary intervention to a certain period of time during the dark phase might entrain the clock and reset the disrupted daily rhythms of AD mice. In this study, exogenous glucagon-like peptide-1 (GLP-1) treatment, time-restricted feeding (TRF), and the combination were used to examine the effect of overall circadian rhythm and neurodegenerative pathogenesis of transgenic AD mice. It was confirmed that GLP-1 administration together with time-restricted feeding improves circadian rhythm of 5 \u00d7 FAD mice including the physiological rhythm of the activity\u2013rest cycle, feeding\u2013fasting cycle, core body temperature, and hormone secretion. Furthermore, GLP-1 and TRF treatments improved the diurnal metabolic homeostasis, spatial cognition, and learning of 5 \u00d7 FAD mice. The aberrant expression of clock genes, including <jats:italic>Baml1<\/jats:italic>, <jats:italic>Clock,<\/jats:italic> and <jats:italic>Dbp<\/jats:italic>, was improved in the hypothalamus, and pathological changes in neurodegeneration and neuroinflammation were also observed in AD mice with dual treatment.<\/jats:p>","DOI":"10.3389\/fphys.2022.911437","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T06:32:42Z","timestamp":1661322762000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Resetting the circadian clock of Alzheimer\u2019s mice via GLP-1 injection combined with time-restricted feeding"],"prefix":"10.3389","volume":"13","author":[{"given":"Yanqiong","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.cmet.2016.01.009","article-title":"Liraglutide compromises pancreatic \u03b2 cell function in a humanized mouse model","volume":"23","author":"Abdulreda","year":"2016","journal-title":"Cell. 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