{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T21:16:52Z","timestamp":1772399812008,"version":"3.50.1"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>From a physiological point of view, peripheral chemoreceptors (PCh) are the main sensors of hypoxia in mammals and are responsible for adaptation to hypoxic conditions. Their stimulation causes hyperventilation\u2014to increase oxygen uptake and increases sympathetic output in order to counteract hypoxia-induced vasodilatation and redistribute the oxygenated blood to critical organs. While this reaction promotes survival in acute settings it may be devastating when long-lasting. The permanent overfunctionality of PCh is one of the etiologic factors and is responsible for the progression of sympathetically-mediated diseases. Thus, the deactivation of PCh has been proposed as a treatment method for these disorders. We review here physiological background and current knowledge regarding the influence of widely prescribed medications on PCh acute and tonic activities.<\/jats:p>","DOI":"10.3389\/fphys.2022.912616","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T08:42:16Z","timestamp":1655196136000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Pharmacological Treatment in the Chemoreflex Modulation"],"prefix":"10.3389","volume":"13","author":[{"given":"Anna","family":"Langner-Hetma\u0144czuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw","family":"Tubek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Niewi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1113\/jphysiol.2012.237800","article-title":"Hypertension Is Critically Dependent on the Carotid Body Input in the Spontaneously Hypertensive Rat","volume":"590","author":"Abdala","year":"2012","journal-title":"J. physiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0006-8993(90)90056-h","article-title":"Inhibiting Carbonic Anhydrase in Brain Tissue Increases the Respiratory Response to Rebreathing CO2","volume":"519","author":"Adams","year":"1990","journal-title":"Brain Res."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2011.183.1_meetingabstracts.a2484","article-title":"Atp Inhibits Carotid Body Glomus Cell Hypoxia Response via P2y12 Receptors","author":"Agarwal","year":"2011","journal-title":"Am. Thorac. Soc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.ejheart.2006.02.001","article-title":"Carvedilol Reduces Exercise-Induced Hyperventilation: A Benefit in Normoxia and a Problem with Hypoxia","volume":"8","author":"Agostoni","year":"2006","journal-title":"Eur. J. heart Fail."},{"key":"B5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00424-020-02492-0","article-title":"\u03b2-Adrenoceptor Blockade Prevents Carotid Body Hyperactivity and Elevated Vascular Sympathetic Nerve Density Induced by Chronic Intermittent Hypoxia","volume":"473","author":"Alzahrani","year":"2021","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1249\/mss.0b013e31817fbe11","article-title":"\u03b2-Adrenergic Blockade and Metabo-Chemoreflex Contributions to ExerciseCapacity","volume":"40","author":"Beloka","year":"2008","journal-title":"Med. Sci. Sports Exerc"},{"key":"B7","first-page":"867.1","article-title":"The Impact of Nitrate Supplementation on the Peripheral Chemoreceptor Reflex to Hypoxia in Older Adults","volume":"31","author":"Bock","year":"","journal-title":"FASEB J."},{"key":"B8","article-title":"Inorganic Nitrate Supplementation Attenuates Peripheral Chemoreflex Sensitivity but Does Not Improve Cardiovagal Baroreflex Sensitivity in Older Adults","volume":"314","author":"Bock","year":"","journal-title":"Am. J. Physiology - Heart Circulatory Physiology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/BF00232772","article-title":"Adenine Nucleotides in the Carotid Body","volume":"206","author":"B\u00f6ck","year":"1980","journal-title":"Cell Tissue Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1160\/TH12-08-0547","article-title":"Why Does Ticagrelor Induce Dyspnea?","volume":"108","author":"Cattaneo","year":"2012","journal-title":"Thromb. Haemost."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1139\/y85-265","article-title":"Effect of Verapamil on Ventilation and Chemical Control of Breathing in Anesthetized Rats","volume":"63","author":"Chapman","year":"1985","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"L1314","DOI":"10.1152\/ajplung.00454.2001","article-title":"Role of Endothelin and Endothelin A-type Receptor in Adaptation of the Carotid Body to Chronic Hypoxia","volume":"282","author":"Chen","year":"2002","journal-title":"Am. J. Physiology-Lung Cell. Mol. Physiology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1016\/j.ijcard.2013.01.277","article-title":"Multiparametric Comparison of CARvedilol, vs. NEbivolol, vs. BIsoprolol in Moderate Heart Failure: the CARNEBI Trial","volume":"168","author":"Contini","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1016\/j.jacc.2013.07.079","article-title":"Carotid Chemoreceptor Ablation Improves Survival in Heart Failure","volume":"62","author":"Del Rio","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1183\/09031936.00158109","article-title":"Carotid Body and Cardiorespiratory Alterations in Intermittent Hypoxia: the Oxidative Link","volume":"36","author":"Del Rio","year":"2010","journal-title":"Eur. Respir. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1183\/09031936.00141511","article-title":"Carotid Body Inflammation and Cardiorespiratory Alterations in Intermittent Hypoxia","volume":"39","author":"Del Rio","year":"2012","journal-title":"Eur. Respir. J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1152\/japplphysiol.01345.2007","article-title":"Downregulation of Carbon Monoxide as Well as Nitric Oxide Contributes to Peripheral Chemoreflex Hypersensitivity in Heart Failure Rabbits","volume":"105","author":"Ding","year":"2008","journal-title":"J. Appl. physiology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1113\/jphysiol.2010.200584","article-title":"Role of Blood Flow in Carotid Body Chemoreflex Function in Heart Failure","volume":"589","author":"Ding","year":"2011","journal-title":"J. Physiology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1113\/jphysiol.1982.sp014441","article-title":"Effects of Low Oxygen on the Release of Dopamine from the Rabbit Carotid Bodyin Vitro","volume":"333","author":"Fidone","year":"1982","journal-title":"J. Physiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1113\/jphysiol.1982.sp014131","article-title":"Adrenergic Mechanisms and Chemoreception in the Carotid Body of the Cat and Rabbit","volume":"325","author":"Folgering","year":"1982","journal-title":"J. physiology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.amjcard.2011.01.060","article-title":"Effect of Acetazolamide on Chemosensitivity, Cheyne-Stokes Respiration, and Response to Effort in Patients with Heart Failure","volume":"107","author":"Fontana","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1161\/hypertensionaha.110.152108","article-title":"Intermittent Hypoxia Increases Arterial Blood Pressure in Humans through a Renin-Angiotensin System-dependent Mechanism","volume":"56","author":"Foster","year":"2010","journal-title":"Hypertension"},{"key":"B23","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3389\/fphys.2014.00336","article-title":"The Role of Local Renin-Angiotensin System in Arterial Chemoreceptors in Sleep-Breathing Disorders","volume":"5","author":"Fung","year":"2014","journal-title":"Front. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1093\/ehjcvp\/pvaa089","article-title":"Central Apnoeas and Ticagrelor-Related Dyspnoea in Patients with Acute Coronary Syndrome","volume":"7","author":"Giannoni","year":"2021","journal-title":"Eur. Heart Journal-Cardiovascular Pharmacother."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1056\/nejmc1601662","article-title":"Cheyne-Stokes Respiration, Chemoreflex, and Ticagrelor-Related Dyspnea","volume":"375","author":"Giannoni","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/0166-2236(92)90357-e","article-title":"Oxygen and Acid Chemoreception in the Carotid Body Chemoreceptors","volume":"15","author":"Gonz\u00e1lez","year":"1992","journal-title":"Trends Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0034-5687(95)00069-0","article-title":"Cellular Mechanisms of Oxygen Chemoreception in the Carotid Body","volume":"102","author":"Gonz\u00e1lez","year":"1995","journal-title":"Respir. Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1378\/chest.06-1775","article-title":"Does Endothelin Play a Role in Chemoreception during Acute Hypoxia in Normal Men?","volume":"131","author":"Gujic","year":"2007","journal-title":"Chest"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1172\/jci106943","article-title":"Effects of Adrenergic Stimulation on Ventilation in Man","volume":"51","author":"Heistad","year":"1972","journal-title":"J. Clin. Invest."},{"key":"B30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0034-5687(86)90042-3","article-title":"Role of Beta Adrenergic Receptors in Carotid Body Function of the Goat","volume":"64","author":"Hudgel","year":"1986","journal-title":"Respir. Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainresrev.2004.05.007","article-title":"Neurotransmission in the Carotid Body: Transmitters and Modulators between Glomus Cells and Petrosal Ganglion Nerve Terminals","volume":"47","author":"Iturriaga","year":"2004","journal-title":"Brain Res. Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1152\/physiol.00031.2021","article-title":"Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex","volume":"37","author":"Iturriaga","year":"2022","journal-title":"Physiology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40659-016-0073-8","article-title":"Carotid Body Chemoreceptors, Sympathetic Neural Activation, and Cardiometabolic Disease","volume":"49","author":"Iturriaga","year":"2016","journal-title":"Biol. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1440-1681.2009.05287.x","article-title":"Digoxin Increases Peripheral Chemosensitivity and the Ventilatory Response to Exercise in Normal Subjects","volume":"37","author":"Janssen","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1513\/annalsats.201306-201oc","article-title":"Acetazolamide Attenuates Hunter-Cheyne-Stokes Breathing but Augments the Hypercapnic Ventilatory Response in Patients with Heart Failure","volume":"11","author":"Javaheri","year":"2014","journal-title":"Ann. ATS"},{"key":"B36","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1046\/j.1365-201x.2003.01083.x","article-title":"Chemoreflexes - Physiology and Clinical Implications","volume":"177","author":"Kara","year":"2003","journal-title":"Acta physiol. Scand."},{"key":"B37","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.bbi.2022.03.014","article-title":"The Carotid Body Detects Circulating Tumor Necrosis Factor-Alpha to Activate a Sympathetic Anti-inflammatory Reflex","volume":"102","author":"Katayama","year":"2022","journal-title":"Brain, Behav. Immun."},{"key":"B38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1369\/0022155412464639","article-title":"Short-term Hypoxia Transiently Increases Dopamine \u03b2-Hydroxylase Immunoreactivity in Glomus Cells of the Rat Carotid Body","volume":"61","author":"Kato","year":"2013","journal-title":"J. Histochem Cytochem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0034-5687(91)90054-m","article-title":"Role of \u03b12-adrenergic Receptors in the Carotid Body Response to Isocapnic Hypoxia","volume":"83","author":"Kou","year":"1991","journal-title":"Respir. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1113\/expphysiol.2013.074591","article-title":"Upregulation of a Local Renin-Angiotensin System in the Rat Carotid Body during Chronic Intermittent Hypoxia","volume":"99","author":"Lam","year":"2014","journal-title":"Exp. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/s0167-0115(02)00068-x","article-title":"A Locally Generated Angiotensin System in Rat Carotid Body","volume":"107","author":"Lam","year":"2002","journal-title":"Regul. Pept."},{"key":"B42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0014-2999(83)90387-4","article-title":"Characterization of Dopamine Autoreceptor and [3H]spiperone Binding Sites In Vitro with Classical and Novel Dopamine Receptor Agonists","volume":"88","author":"Lehmann","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1136\/bmj.1.6006.365","article-title":"Effect of Intravenous Infusion of Salbutamol on Ventilatory Response to Carbon Dioxide and Hypoxia and on Heart Rate and Plasma Potassium in Normal Men","volume":"1","author":"Leitch","year":"1976","journal-title":"Bmj"},{"key":"B44","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fphys.2018.00225","article-title":"Sensory Processing and Integration at the Carotid Body Tripartite Synapse: Neurotransmitter Functions and Effects of Chronic Hypoxia","volume":"9","author":"Leonard","year":"2018","journal-title":"Front. Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/s1357-2725(02)00180-2","article-title":"Renin-angiotensin System in the Carotid Body","volume":"35","author":"Leung","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0079-6107(94)90005-1","article-title":"The Cellular Actions of Digitalis Glycosides on the Heart","volume":"62","author":"Levi","year":"1994","journal-title":"Prog. biophysics Mol. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1161\/01.res.0000175722.21555.55","article-title":"Gene Transfer of Neuronal Nitric Oxide Synthase to Carotid Body Reverses Enhanced Chemoreceptor Function in Heart Failure Rabbits","volume":"97","author":"Li","year":"2005","journal-title":"Circulation Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.cardiores.2007.04.006","article-title":"NADPH Oxidase-Derived Superoxide Anion Mediates Angiotensin II-Enhanced Carotid Body Chemoreceptor Sensitivity in Heart Failure Rabbits","volume":"75","author":"Li","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cardiores.2006.03.017","article-title":"Angiotensin II Enhances Carotid Body Chemoreflex Control of Sympathetic Outflow in Chronic Heart Failure Rabbits","volume":"71","author":"Li","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1152\/japplphysiol.00723.2015","article-title":"Interindividual Variability in the Dose-specific Effect of Dopamine on Carotid Chemoreceptor Sensitivity to Hypoxia","volume":"120","author":"Limberg","year":"2016","journal-title":"J. Appl. Physiology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"L158","DOI":"10.1152\/ajplung.90383.2008","article-title":"Adaptation to Chronic Hypoxia Involves Immune Cell Invasion and Increased Expression of Inflammatory Cytokines in Rat Carotid Body","volume":"296","author":"Liu","year":"2009","journal-title":"Am. J. Physiology-Lung Cell. Mol. Physiology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0034-5687(89)90061-3","article-title":"Ventilatory Response to Sustained Hypoxia: Effect of Methysergide and Verapamil","volume":"75","author":"Long","year":"1989","journal-title":"Respir. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1038\/ncomms3395","article-title":"The Carotid Body as a Putative Therapeutic Target for the Treatment of Neurogenic Hypertension","volume":"4","author":"Mcbryde","year":"2013","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1113\/jphysiol.1983.sp014530","article-title":"Effects of Ouabain on Carotid Body Chemoreceptor Activity in the Cat","volume":"335","author":"Mcqueen","year":"1983","journal-title":"J. Physiology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1111\/j.1471-4159.1983.tb04792.x","article-title":"Biogenic Amine-Stimulated Cyclic Adenosine-3',5'-Monophosphate Formation in the Rat Carotid Body","volume":"41","author":"Mir","year":"1983","journal-title":"J. Neurochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1113\/ep087006","article-title":"Effects of Losartan and Allopurinol on Cardiorespiratory Regulation in Obstructive Sleep Apnoea","volume":"103","author":"Morgan","year":"2018","journal-title":"Exp. Physiol."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00284-2020","article-title":"Design and Rationale of Two Phase 3 Randomised Controlled Trials (COUGH-1 and COUGH-2) of Gefapixant, a P2X3 Receptor Antagonist, in Refractory or Unexplained Chronic Cough","volume":"6","author":"Muccino","year":"2020","journal-title":"ERJ Open Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jacbts.2016.06.004","article-title":"Unilateral Carotid Body Resection in Resistant Hypertension","volume":"1","author":"Narkiewicz","year":"2016","journal-title":"JACC Basic Transl. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.cardfail.2013.03.013","article-title":"Clinical Predictors and Hemodynamic Consequences of Elevated Peripheral Chemosensitivity in Optimally Treated Men with Chronic Systolic Heart Failure","volume":"19","author":"Niewinski","year":"2013","journal-title":"J. cardiac Fail."},{"key":"B60","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/ejhf.641","article-title":"Carotid Body Resection for Sympathetic Modulation in Systolic Heart Failure: Results from First-In-Man Study","volume":"19","author":"Niewinski","year":"2017","journal-title":"Eur. J. Heart Fail"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1113\/jphysiol.2013.266858","article-title":"Consequences of Peripheral Chemoreflex Inhibition with Low-Dose Dopamine in Humans","volume":"592","author":"Niewinski","year":"2014","journal-title":"J. physiology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1113\/jp281319","article-title":"Oxygenation Pattern and Compensatory Responses to Hypoxia and Hypercapnia Following Bilateral Carotid Body Resection in Humans","volume":"599","author":"Niewinski","year":"2021","journal-title":"J. Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"H59","DOI":"10.1152\/ajpheart.00163.2017","article-title":"Acute Beetroot Juice Supplementation on Sympathetic Nerve Activity: a Randomized, Double-Blind, Placebo-Controlled Proof-Of-Concept Study","volume":"313","author":"Notay","year":"2017","journal-title":"Am. J. Physiology-Heart Circulatory Physiology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1242\/jeb.100.1.23","article-title":"Role of Peripheral Chemoreceptors and Central Chemosensitivity in the Regulation of Respiration and Circulation","volume":"100","author":"O'Regan","year":"1982","journal-title":"J. Exp. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1161\/circulationaha.107.728840","article-title":"Inotropes and Vasopressors","volume":"118","author":"Overgaard","year":"2008","journal-title":"Circulation"},{"key":"B66","first-page":"335","article-title":"Effects of Digoxin on Chemoreflex in Patients with Chronic Heart Failure","volume":"47","author":"Paganelli","year":"2001","journal-title":"Cell Mol. Biol. (Noisy-le-grand)"},{"key":"B67","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1365-2125.2006.02657.x","article-title":"Dose-dependent Effect of Dobutamine on Chemoreflex Activity in Healthy Volunteers","volume":"62","author":"Pathak","year":"2006","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s11906-013-0366-z","article-title":"Revelations about Carotid Body Function through its Pathological Role in Resistant Hypertension","volume":"15","author":"Paton","year":"","journal-title":"Curr. Hypertens. Rep."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.00064","article-title":"The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases","volume":"61","author":"Paton","year":"","journal-title":"Hypertension"},{"key":"B70","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1161\/circresaha.121.319874","article-title":"GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition","volume":"130","author":"Pauza","year":"2022","journal-title":"Circ. Res."},{"key":"B71","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-2966-8_39","article-title":"Neurotransmitters and Second Messenger Systems in the Carotid Body","volume-title":"Neurobiol. Cell Physiology Chemorecept.","author":"P\u00e9rez-Garc\u00eda","year":"1993"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/nm.4173","article-title":"Purinergic Receptors in the Carotid Body as a New Drug Target for Controlling Hypertension","volume":"22","author":"Pijacka","year":"2016","journal-title":"Nat. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-4615-2572-1_6","article-title":"Neurotransmitters in the Carotid Body","author":"Prabhakar","year":"1994","journal-title":"Arter. Chemorecept."},{"key":"B74","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/sj.bjp.0701652","article-title":"Modulation of Transcription Factor NF-\u039ab by Enantiomers of the Nonsteroidal Drug Ibuprofen","volume":"123","author":"Scheuren","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1161\/01.hyp.23.3.302","article-title":"Differential Effects of Digitalis on Chemoreflex Responses in Humans","volume":"23","author":"Schobel","year":"1994","journal-title":"Hypertension"},{"key":"B76","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.coph.2010.12.004","article-title":"Angiotensin and Carotid Body Chemoreception in Heart Failure","volume":"11","author":"Schultz","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1161\/hypertensionaha.106.076083","article-title":"Arterial Chemoreceptors and Sympathetic Nerve Activity","volume":"50","author":"Schultz","year":"2007","journal-title":"Hypertension"},{"key":"B78","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s11906-013-0368-x","article-title":"Role of the Carotid Body in the Pathophysiology of Heart Failure","volume":"15","author":"Schultz","year":"2013","journal-title":"Curr. Hypertens. Rep."},{"key":"B79","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1161\/circresaha.119.315338","article-title":"Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body","volume":"125","author":"Shin","year":"2019","journal-title":"Circ. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1152\/jappl.1991.71.3.1062","article-title":"Dependency of Hypoxic Chemotransduction in Cat Carotid Body on Voltage-Gated Calcium Channels","volume":"71","author":"Shirahata","year":"1991","journal-title":"J. Appl. physiology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/hr.2011.209","article-title":"Tonic Activity of Carotid Body Chemoreceptors Contributes to the Increased Sympathetic Drive in Essential Hypertension","volume":"35","author":"Si\u0144ski","year":"2012","journal-title":"Hypertens. Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1023\/a:1007784109255","article-title":"Beta-blocker Selectivity at Cloned Human Beta1-And Beta2-Adrenergic Receptors","volume":"13","author":"Smith","year":"1999","journal-title":"Cardiovasc. drugs Ther."},{"key":"B83","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.autneu.2014.01.010","article-title":"Ventilatory Responses to Chemoreflex Stimulation Are Not Enhanced by Angiotensin II in Healthy Humans","volume":"183","author":"Solaiman","year":"2014","journal-title":"Aut. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"20823","DOI":"10.1038\/s41598-021-99159-2","article-title":"Acute Hyperoxia Reveals Tonic Influence of Peripheral Chemoreceptors on Systemic Vascular Resistance in Heart Failure Patients","volume":"11","author":"Tubek","year":"2021","journal-title":"Sci. Rep."},{"key":"B85","article-title":"Human Carotid Bodies as a Therapeutic Target: New Insights from Clinician Perspective","volume":"76","author":"Tubek","year":"2018","journal-title":"Kardiologia Pol. Pol. Heart J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.1113\/jp272109","article-title":"Effects of Selective Carotid Body Stimulation with Adenosine in Conscious Humans","volume":"594","author":"Tubek","year":"2016","journal-title":"J. Physiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1161\/01.cir.98.2.126","article-title":"Dopamine Depresses Minute Ventilation in Patients with Heart Failure","volume":"98","author":"Van De Borne","year":"1998","journal-title":"Circulation"},{"key":"B88","doi-asserted-by":"publisher","first-page":"H1356","DOI":"10.1152\/ajpheart.01126.2002","article-title":"Dobutamine Potentiates Arterial Chemoreflex Sensitivity in Healthy Normal Humans","volume":"285","author":"Velez-Roa","year":"2003","journal-title":"Am. J. Physiology-Heart Circulatory Physiology"},{"key":"B89","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1469-445x.2000.02016.x","article-title":"Changes in Chemoreflex Characteristics Following Acute Carbonic Anhydrase Inhibition in Humans a Rest","volume":"85","author":"Vovk","year":"2000","journal-title":"Exp. Physiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1183\/09031936.98.12061271","article-title":"Effect of Low-Dose Acetazolamide on the Ventilatory CO2 Response during Hypoxia in the Anaesthetized Cat","volume":"12","author":"Wagenaar","year":"1998","journal-title":"Eur. Respir. J."},{"key":"B91","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/cne.903360308","article-title":"Neurons Synthesizing Nitric Oxide Innervate the Mammalian Carotid Body","volume":"336","author":"Wang","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1034\/j.1399-3003.2000.15.06.x","article-title":"The Effect of Amlodipine on Respiratory and Pulmonary Vascular Responses to Hypoxia in Mountaineers","volume":"15","author":"Watt","year":"2000","journal-title":"Eur. Respir. J."},{"key":"B93","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/jappl.1972.33.6.813","article-title":"Augmentation of Chemosensitivity during Mild Exercise in Normal Man","volume":"33","author":"Weil","year":"1972","journal-title":"J. Appl. Physiology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1172\/jci108983","article-title":"Depression of Ventilation by Dopamine in Man","volume":"61","author":"Welsh","year":"1978","journal-title":"J. Clin. Invest."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1113\/expphysiol.2014.079491","article-title":"Tonic Arterial Chemoreceptor Activity Contributes to Cardiac Sympathetic Activation in Mild Ovine Heart Failure","volume":"99","author":"Xing","year":"2014","journal-title":"Exp. Physiol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00441-006-0178-4","article-title":"Hypoxia Induces Production of Nitric Oxide and Reactive Oxygen Species in Glomus Cells of Rat Carotid Body","volume":"325","author":"Yamamoto","year":"2006","journal-title":"Cell Tissue Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s00424-002-0785-1","article-title":"Augmentation of Hypoxia-Induced Nitric Oxide Generation in the Rat Carotid Body Adapted to Chronic Hypoxia: an Involvement of Constitutive and Inducible Nitric Oxide Synthases","volume":"444","author":"Ye","year":"","journal-title":"Pfl\u00fcgers Arch. - Eur. J. Physiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1161\/01.hyp.0000018590.26853.c7","article-title":"Losartan Reduces Central and Peripheral Sympathetic Nerve Activity in a Rat Model of Neurogenic Hypertension","volume":"39","author":"Ye","year":"","journal-title":"Hypertension"},{"key":"B99","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1136\/thx.50.2.139","article-title":"Effects of Fenoterol on Ventilatory Responses to Hypoxia and Hypercapnia in Normal Subjects","volume":"50","author":"Yoshiike","year":"1995","journal-title":"Thorax"},{"key":"B100","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fphys.2018.00249","article-title":"Leptin Signaling in the Carotid Body Regulates a Hypoxic Ventilatory Response through Altering TASK Channel Expression","volume":"9","author":"Yuan","year":"2018","journal-title":"Front. Physiol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1152\/physiol.00057.2018","article-title":"The Logic of Carotid Body Connectivity to the Brain","volume":"34","author":"Zera","year":"2019","journal-title":"Physiology"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.912616\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T11:26:01Z","timestamp":1678188361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2022.912616\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":101,"alternative-id":["10.3389\/fphys.2022.912616"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2022.912616","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"article-number":"912616"}}