{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:28:58Z","timestamp":1792153738442,"version":"4.4.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>The development of preeclampsia during pregnancy may have long-term effects on brain aging in women. Associations between preeclampsia and vascular dementia have been established, however the connection between preeclampsia and Alzheimer\u2019s disease has not been as thoroughly explored. Both preeclampsia and Alzheimer\u2019s disease have been associated with misfolded amyloid beta proteins and inflammation; due to these similarities, in this minireview, we examined the potential links between a history of preeclampsia and the development of dementia. We also discussed how hypertensive disorders of pregnancy may relate to both normal brain aging and dementia to highlight the need for additional research regarding the long-term cognitive effects of preeclampsia on the brain.<\/jats:p>","DOI":"10.3389\/fphys.2022.979547","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T04:36:36Z","timestamp":1665981396000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Preeclampsia and its relationship to pathological brain aging"],"prefix":"10.3389","volume":"13","author":[{"given":"Abigail A.","family":"Testo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira M.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Dumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e709","DOI":"10.1212\/WNL.0000000000011363","article-title":"Hypertensive disorders of pregnancy and cognitive impairment: A prospective cohort study","volume":"96","author":"Adank","year":"2021","journal-title":"Neurology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0246786","DOI":"10.1371\/journal.pone.0246786","article-title":"Signs of neuroaxonal injury in preeclampsia-A case control study","volume":"16","author":"Andersson","year":"2021","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1111\/1471-0528.16201","article-title":"Prior placental bed disorders and later dementia: A retrospective Swedish register-based cohort study","volume":"127","author":"Andolf","year":"2020","journal-title":"Bjog"},{"key":"B4","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/aogs.13096","article-title":"Hypertensive disorders in pregnancy and later dementia: A Swedish national register study","volume":"96","author":"Andolf","year":"2017","journal-title":"Acta Obstet. 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