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Physiol."],"abstract":"<jats:p>Acute high-altitude diseases, including acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE), have been recognized as potentially lethal diseases for altitude climbers. Various preconditioning stimuli, including hyperbaric oxygen (HBO), have been proposed to prevent acute high-altitude diseases. Herein, we reviewed whether and how HBO preconditioning could affect high-altitude diseases and summarized the results of current trials. Evidence suggests that HBO preconditioning may be a safe and effective preventive method for acute high-altitude diseases. The proposed mechanisms of HBO preconditioning in preventing high-altitude diseases may involve: 1) protection of the blood-brain barrier and prevention of brain edema, 2) inhibition of the inflammatory responses, 3) induction of the hypoxia-inducible factor and its target genes, and 4) increase in antioxidant activity. However, the optimal protocol of HBO preconditioning needs further exploration. Translating the beneficial effects of HBO preconditioning into current practice requires the \u201cconditioning strategies\u201d approach. More large-scale and high-quality randomized controlled studies are needed in the future.<\/jats:p>","DOI":"10.3389\/fphys.2023.1019103","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T08:31:10Z","timestamp":1674635470000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Hyperbaric oxygen preconditioning for prevention of acute high-altitude diseases: Fact or fiction?"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiuhong","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s12192-017-0795-8","article-title":"Oxidative protein modification alters proteostasis under acute hypobaric hypoxia in skeletal muscles: A comprehensive in vivo study","volume":"22","author":"Agrawal","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"B2","doi-asserted-by":"publisher","first-page":"866093","DOI":"10.3389\/fcvm.2022.866093","article-title":"Systemic blood predictors of elevated pulmonary artery pressure assessed by non-invasive echocardiography after acute exposure to high altitude: A prospective cohort study","volume":"9","author":"Bian","year":"2022","journal-title":"Front. 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