{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:22:21Z","timestamp":1790824941242,"version":"4.1.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> The purpose of this study was to evaluate the effect of pre-exercise alkalosis, induced <jats:italic>via<\/jats:italic> ingestion of sodium bicarbonate, on changes to lactate\/pH regulatory proteins and mitochondrial function induced by a sprint-interval exercise session in humans.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> On two occasions separated by 1\u00a0week, eight active men performed a 3 \u00d7 30-s all-out cycling test, interspersed with 20\u00a0min of recovery, following either placebo (PLA) or sodium bicarbonate (BIC) ingestion.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Blood bicarbonate and pH were elevated at all time points after ingestion in BIC vs PLA (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The protein content of monocarboxylate transporter 1 (MCT1) and basigin (CD147), at 6\u00a0h and 24\u00a0h post-exercise, and sodium\/hydrogen exchanger 1 (NHE1) 24\u00a0h post-exercise, were significantly greater in BIC compared to PLA (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), whereas monocarboxylate transporter 4 (MCT4), sodium\/bicarbonate cotransporter (NBC), and carbonic anhydrase isoform II (CAII) content was unchanged. These increases in protein content in BIC vs. PLA after acute sprint-interval exercise may be associated with altered physiological responses to exercise, such as the higher blood pH and bicarbonate concentration values, and lower exercise-induced oxidative stress observed during recovery (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Additionally, mitochondrial respiration decreased after 24\u00a0h of recovery in the BIC condition only, with no changes in oxidative protein content in either condition.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These data demonstrate that metabolic alkalosis induces post-exercise increases in several lactate\/pH regulatory proteins, and reveal an unexpected role for acidosis in mitigating the loss of mitochondrial respiration caused by exercise in the short term.<\/jats:p>","DOI":"10.3389\/fphys.2023.1073407","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:22:53Z","timestamp":1674796973000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of pre-exercise alkalosis on lactate\/pH regulation and mitochondrial respiration following sprint-interval exercise in humans"],"prefix":"10.3389","volume":"14","author":[{"given":"Claire","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Delfour\u2010Peyrethon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/bf00376501","article-title":"Muscle function during brief maximal exercise: Accurate measurements on a friction-loaded cycle ergometer","volume":"74","author":"Arsac","year":"1996","journal-title":"Eur. J. Appl. Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1113\/jphysiol.1993.sp019546","article-title":"Lactate and H+ effluxes from human skeletal muscles during intense, dynamic exercise","volume":"462","author":"Bangsbo","year":"1993","journal-title":"J. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1469-7793.1997.489be.x","article-title":"Dissociation between lactate and proton exchange in muscle during intense exercise in man","volume":"504","author":"Bangsbo","year":"1997","journal-title":"J. Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0006-3495(04)74099-0","article-title":"Facilitated lactate transport by MCT1 when coexpressed with the sodium bicarbonate cotransporter (NBC) in Xenopus oocytes","volume":"86","author":"Becker","year":"2004","journal-title":"Biophys. J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"21655","DOI":"10.1074\/jbc.m802134200","article-title":"Nonenzymatic proton handling by carbonic anhydrase II during H+-Lactate cotransport via monocarboxylate transporter 1","volume":"283","author":"Becker","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1073\/pnas.1014293108","article-title":"Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II","volume":"108","author":"Becker","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B7","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s00421-005-0100-x","article-title":"The effects of short-term sprint training on MCT expression in moderately endurance-trained runners","author":"Bickham","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1249\/01.mss.0000126392.20025.17","article-title":"Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability","volume":"36","author":"Bishop","year":"2004","journal-title":"Med. Sci. Sports Exerc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1152\/japplphysiol.00590.2006","article-title":"High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle","volume":"102","author":"Bishop","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00424-009-0673-z","article-title":"High-intensity exercise decreases muscle buffer capacity via a decrease in protein buffering in human skeletal muscle","volume":"458","author":"Bishop","year":"2009","journal-title":"Eur. J. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1152\/ajpendo.00738.2009","article-title":"Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats","volume":"299","author":"Bishop","year":"2010","journal-title":"Am. J. Physiol. - Endocrinol. Metab."},{"key":"B12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1600-0838.2005.00448.x","article-title":"A comparison between three rating scales for perceived exertion and two different work tests","volume":"16","author":"Borg","year":"2006","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B13","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","article-title":"The science and translation of lactate shuttle theory","volume":"27","author":"Brooks","year":"2018","journal-title":"Cell Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00421-012-2484-8","article-title":"Sodium bicarbonate supplementation improves hypertrophy-type resistance exercise performance","volume":"113","author":"Carr","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1113\/jphysiol.2004.073478","article-title":"Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle","volume":"561","author":"Coles","year":"2004","journal-title":"J. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/s0891-5849(02)01086-9","article-title":"Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: The involvement of the oxidative stress response regulators Yap1 and Skn7","volume":"33","author":"Costa","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1042\/bj3500219","article-title":"The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells","author":"Dimmer","year":"2000","journal-title":"Biochem. J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1152\/jappl.1999.87.3.955","article-title":"Lactate transport activity in rat skeletal muscle sarcolemmal vesicles after acute exhaustive exercise","volume":"87","author":"Dubouchaud","year":"1999","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"B19","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1152\/japplphysiol.01534.2005","article-title":"Effects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performance","volume":"101","author":"Edge","year":"2006","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e0141317","DOI":"10.1371\/journal.pone.0141317","article-title":"Ammonium chloride ingestion attenuates exercise-induced mRNA levels in human muscle","volume":"10","author":"Edge","year":"2015","journal-title":"PLOS ONE"},{"key":"B21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1249\/00005768-198201000-00018","article-title":"Suction applied to a muscle biopsy maximizes sample size","volume":"14","author":"Evans","year":"1982","journal-title":"Med. Sci. Sports Exerc."},{"key":"B22","doi-asserted-by":"publisher","first-page":"E1045","DOI":"10.1152\/ajpendo.2000.278.6.E1045","article-title":"Training does not protect against exhaustive exercise-induced lactate transport capacity alterations","volume":"278","author":"Eydoux","year":"2000","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1152\/japplphysiol.01173.2006","article-title":"Reduced efficiency, but increased fat oxidation, in mitochondria from human skeletal muscle after 24-h ultraendurance exercise","volume":"102","author":"Fernstr\u00f6m","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"C404","DOI":"10.1152\/ajpcell.00214.2018","article-title":"A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes","volume":"316","author":"Genders","year":"2019","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1113\/jphysiol.2006.112094","article-title":"Short-term sprint interval versus traditional endurance training: Similar initial adaptations in human skeletal muscle and exercise performance","volume":"575","author":"Gibala","year":"2006","journal-title":"J. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/bf00373617","article-title":"The effect of high-intensity exercise on the respiratory capacity of skeletal muscle","volume":"415","author":"Gollnick","year":"1990","journal-title":"Pfl\u00fcg. Arch."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7056","DOI":"10.1038\/s41467-021-27153-3","article-title":"High-intensity training induces non-stoichiometric changes in the mitochondrial proteome of human skeletal muscle without reorganisation of respiratory chain content","volume":"12","author":"Granata","year":"2021","journal-title":"Nat. Commun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1096\/fj.201500100r","article-title":"Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle","volume":"30","author":"Granata","year":"2016","journal-title":"FASEB J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/bf00601809","article-title":"Aerobic and anaerobic contribution to Wingate test performance in sprint and middle-distance runners","volume":"70","author":"Granier","year":"1995","journal-title":"Eur. J. Appl. Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"15512602","DOI":"10.1519\/JSC.0b013e318231a6b5","article-title":"Effect of two different long-sprint training regimens on sprint performance and associated metabolic responses","volume":"26","author":"Hanon","year":"2012","journal-title":"J. Strength Cond. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1096\/fj.07-8174com","article-title":"Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis","volume":"21","author":"Hashimoto","year":"2007","journal-title":"FASEB J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1113\/jphysiol.2005.087411","article-title":"Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle","volume":"567","author":"Hashimoto","year":"2005","journal-title":"J. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1152\/japplphysiol.00427.2013","article-title":"Exercise-inducible factors to activate lipolysis in adipocytes","volume":"115","author":"Hashimoto","year":"2013","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"B35","doi-asserted-by":"publisher","first-page":"E316","DOI":"10.1152\/ajpendo.2000.278.2.e316","article-title":"Effect of induced metabolic alkalosis on human skeletal muscle metabolism during exercise","volume":"278","author":"Hollidge-Horvat","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e12555","DOI":"10.14814\/phy2.12555","article-title":"Effects of decreased lactate accumulation after dichloroacetate administration on exercise training\u2013induced mitochondrial adaptations in mouse skeletal muscle","volume":"3","author":"Hoshino","year":"2015","journal-title":"Physiol. Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1038\/ncomms3147","article-title":"A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle","volume":"4","author":"Ikeda","year":"2013","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1113\/jphysiol.2003.045872","article-title":"Acidosis inhibits oxidative phosphorylation in contracting human skeletal muscle in vivo","volume":"553","author":"Jubrias","year":"2003","journal-title":"J. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"E245","DOI":"10.1152\/ajpendo.00303.2003","article-title":"Effect of high-intensity intermittent training on lactate and H+ release from human skeletal muscle","volume":"286","author":"Juel","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B41","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1046\/j.1365-201X.1996.206000.x","article-title":"Lactate\/proton co-transport in skeletal muscle: Regulation and importance for pH homeostasis","volume":"156","author":"Juel","year":"1996","journal-title":"Acta Physiol. Scand."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3550","DOI":"10.1038\/ncomms4550","article-title":"Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival","volume":"5","author":"Khacho","year":"2014","journal-title":"Nat. Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","article-title":"CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression","volume":"19","author":"Kirk","year":"2000","journal-title":"EMBO J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.2460\/ajvr.73.11.1813","article-title":"Effects of high-intensity training on lipid metabolism in Thoroughbreds","volume":"73","author":"Kitaoka","year":"2012","journal-title":"Am. J. Vet. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1365-201x.2004.01297.x","article-title":"Expression of Na+\/HCO3- co-transporter proteins (NBCs) in rat and human skeletal muscle","volume":"182","author":"Kristensen","year":"2004","journal-title":"Acta Physiol. Scand."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e13772","DOI":"10.1111\/apha.13772","article-title":"Assessing mitochondrial respiration in permeabilized fibres and biomarkers for mitochondrial content in human skeletal muscle","volume":"234","author":"Kuang","year":"2022","journal-title":"Acta Physiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1096\/fj.15-276857","article-title":"High\u2010intensity sprint training inhibits mitochondrial respiration through aconitase inactivation","volume":"30","author":"Larsen","year":"2016","journal-title":"FASEB J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.1093\/nar\/gks066","article-title":"Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression","volume":"40","author":"Latham","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1249\/mss.0000000000001735","article-title":"Acute high-intensity exercise impairs skeletal muscle respiratory capacity","volume":"50","author":"Layec","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"B50","doi-asserted-by":"publisher","first-page":"R1303","DOI":"10.1152\/ajpregu.00538.2010","article-title":"An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1\u03b1 and activates mitochondrial biogenesis in human skeletal muscle","volume":"300","author":"Little","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e39081","DOI":"10.1371\/journal.pone.0039081","article-title":"Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets","volume":"7","author":"Liu","year":"2012","journal-title":"PloS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3389\/fendo.2014.00195","article-title":"Gender differences in skeletal muscle substrate metabolism - molecular mechanisms and insulin sensitivity","volume":"5","author":"Lundsgaard","year":"2014","journal-title":"Front. Endocrinol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1469-7793.2000.00285.x","article-title":"Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle","author":"Manning Fox","year":"2000","journal-title":"J. Physiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1152\/japplphysiol.00630.2016","article-title":"Influence of training intensity on adaptations in acid\/base transport proteins, muscle buffer capacity, and repeated-sprint ability in active men","volume":"121","author":"McGinley","year":"2016","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"B55","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/jn\/134.3.558","article-title":"Chronic metabolic acidosis increases mRNA levels for components of the ubiquitin-mediated proteolytic pathway in skeletal muscle of dairy cows","volume":"134","author":"Mutsvangwa","year":"2004","journal-title":"J. Nutr."},{"key":"B56","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s13105-013-0263-6","article-title":"Exercise-induced changes of MCT1 in cardiac and skeletal muscles of diabetic rats induced by high-fat diet and STZ","volume":"69","author":"Nikooie","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1152\/japplphysiol.00048.2015","article-title":"Sodium bicarbonate ingestion augments the increase in PGC-1\u03b1 mRNA expression during recovery from intense interval exercise in human skeletal muscle","volume":"119","author":"Percival","year":"2015","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"B58","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","article-title":"High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle","volume":"810","author":"Pesta","year":"2012","journal-title":"Methods Mol. Biol. Clifton N. J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"E843","DOI":"10.1152\/ajpendo.1999.276.5.e843","article-title":"Distribution of the lactate\/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle","volume":"276","author":"Pilegaard","year":"1999","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"B61","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10456-012-9282-0","article-title":"Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice","volume":"15","author":"Porporato","year":"2012","journal-title":"Angiogenesis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1089\/ars.2011.4498","article-title":"Oxygen consumption and usage during physical exercise: The balance between oxidative stress and ROS-dependent adaptive signaling","volume":"18","author":"Radak","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s00421-012-2551-1","article-title":"The Moxus Modular metabolic system evaluated with two sensors for ventilation against the Douglas bag method","volume":"113","author":"Rosdahl","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1136\/gut.2009.181412","article-title":"CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models","volume":"58","author":"Schneiderhan","year":"2009","journal-title":"Gut"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e27167","DOI":"10.1371\/journal.pone.0027167","article-title":"Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase","volume":"6","author":"Schueler","year":"2011","journal-title":"PloS One"},{"key":"B66","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(69)13005-0","article-title":"Citrate synthase: [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)]","volume-title":"Methods in enzymology citric acid cycle","author":"Srere","year":"1969"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1113\/jphysiol.2011.220152","article-title":"Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II","volume":"590","author":"Stridh","year":"2012","journal-title":"J. Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"E916","DOI":"10.1152\/ajpendo.00164.2007","article-title":"Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: Influence of chronic metabolic alkalosis","volume":"293","author":"Thomas","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B69","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00421-015-3239-0","article-title":"Effects of pre-exercise alkalosis on the decrease in VO2 at the end of all-out exercise","volume":"116","author":"Thomas","year":"2016","journal-title":"Eur. J. Appl. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1519\/JSC.0000000000003855","article-title":"Positive effects of pre-exercise metabolic alkalosis on perceived exertion and post-exercise squat jump performance in world-class cyclists","volume":"36","author":"Thomas","year":"2021","journal-title":"J. Strength Cond. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1152\/japplphysiol.01057.2004","article-title":"Monocarboxylate transporters, blood lactate removal after supramaximal exercise, and fatigue indexes in humans","volume":"98","author":"Thomas","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"C288","DOI":"10.1152\/ajpcell.1999.277.2.C288","article-title":"Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria","volume":"277","author":"Tonkonogi","year":"1999","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"E1062","DOI":"10.1152\/ajpendo.00358.2001","article-title":"Muscle contraction increases lactate transport while reducing sarcolemmal MCT4, but not MCT1","volume":"282","author":"Tonouchi","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B74","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1249\/mss.0b013e3181b71a4a","article-title":"Effect of induced alkalosis on the power-duration relationship of \u201call-out\u201d exercise","volume":"42","author":"Vanhatalo","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"B75","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fphys.2015.00051","article-title":"Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training","volume":"6","author":"Vincent","year":"2015","journal-title":"Front. Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12970-019-0285-8","article-title":"Effect of sodium bicarbonate ingestion during 6 weeks of HIIT on anaerobic performance of college students","volume":"16","author":"Wang","year":"2019","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1007\/s00421-011-1938-8","article-title":"Bicarbonate ingestion has no ergogenic effect on consecutive all out sprint tests in BMX elite cyclists","volume":"111","author":"Zabala","year":"2011","journal-title":"Eur. J. Appl. Physiol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1073407\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T05:22:56Z","timestamp":1674796976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1073407\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":74,"alternative-id":["10.3389\/fphys.2023.1073407"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1073407","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"article-number":"1073407"}}