{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:17:43Z","timestamp":1792876663392,"version":"4.5.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> We investigated the associations between physical activity (PA) and cardiorespiratory fitness (CRF) with vascular health phenotypes in community-dwelling older adults.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This cross-sectional study included 82 participants (66.8 \u00b1 5.2\u00a0years; 81% females). Moderate-to-vigorous physical activity (MVPA) was assessed using accelerometers, and CRF was measured using the distance covered in the 6-min walk test (6MWT). The vascular health markers were as follows: i) arterial function measured as aortic pulse wave velocity (aPWV) estimated using an automatic blood pressure device; and ii) arterial structure measured as the common carotid intima-media thickness (cIMT). Using a combination of normal cIMT and aPWV values, four groups of vascular health phenotypes were created: normal aPWV and cIMT, abnormal aPWV only, abnormal cIMT only, and abnormal aPWV and cIMT. Multiple linear regression was used to estimate the beta coefficients (<jats:italic>\u03b2<\/jats:italic>) and their respective 95% confidence intervals (95% CI) adjusting for BMI, and medication for diabetes, lipid, and hypertension, sex, age, and blood pressure.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Participants with abnormal aPWV and normal cIMT (\u03b2 = \u221253.76; 95% CI = \u221297.73\u2014\u22129.78\u00a0m; <jats:italic>p<\/jats:italic> = 0.017), and participants with both abnormal aPWV and cIMT (\u03b2 = \u221271.89; 95% CI = \u2212125.46\u2014\u221218.31\u00a0m; <jats:italic>p<\/jats:italic> = 0.009) covered less distance in the 6MWT, although adjusting for age, sex and blood pressure decreased the strength of the association with only groups of abnormal aPWV and cIMT covering a lower 6MWT distance compared to participants with both normal aPWV and cIMT (\u03b2 = \u221255.68 95% CI = \u2212111.95\u20130.59; <jats:italic>p<\/jats:italic> = 0.052). No associations were observed between MVPA and the vascular health phenotypes.<\/jats:p><jats:p><jats:bold>Conslusion:<\/jats:bold> In summary, poor CRF, but not MVPA, is associated with the unhealthiest vascular health phenotype (abnormal aPWV\/cIMT) in older adults.<\/jats:p>","DOI":"10.3389\/fphys.2023.1096139","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T04:41:37Z","timestamp":1684125697000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between physical activity and cardiorespiratory fitness with vascular health phenotypes in older adults: a cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Maria Karolina Ferreira","family":"de Sousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00edssa de Melo","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri Alberto","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Costa","family":"Souto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcyo","family":"C\u00e2mara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila Lucena Pereira","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geovani Ara\u00fajo Dantas","family":"Mac\u00eado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Caldas","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Santos","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: Guidelines for the six-minute walk test","volume":"166","year":"2002","journal-title":"Am. 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