{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:22:26Z","timestamp":1792160546517,"version":"4.4.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To describe the clinical spectrum of severe <jats:italic>Chlamydia psittaci<\/jats:italic> pneumonia in order to understand the disease better.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Retrospective analysis was made on 31 patients with severe <jats:italic>Chlamydia psittaci<\/jats:italic> pneumonia diagnosed in ICU by next-generation sequencing of metagenome Metagenomic next-generation sequencing(mNGS) from January 2019\u2013November 2022, including clinical characteristics, laboratory examination results, imaging characteristics, treatment, and prognosis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We included 31 patients with severe <jats:italic>Chlamydia psittaci<\/jats:italic> pneumonia, 15 of whom had a history of virus exposure. There were 12 cases with multiple bacterial infections, and the common symptoms included fever (31\/31,100%), dyspnea (31\/31, 100%), cough (22\/31, 71.0%), and myalgia (20\/31, 64.5%). Laboratory data showed that white blood cells were average or slightly increased, but the levels of C-reactive protein and neutrophils were high. CT findings of the lung were consolidation (19\/31, 61.3%) and pleural effusion (11\/31, 35.5%). Only one lobe was involved in 11 patients (35.5%). Before diagnosis, 22 patients (71.0%) did not have atypical pathogens in their antimicrobial regimen. After diagnosis, 19 patients (61.3%) received single drug treatment, of which doxycycline or moxifloxacin were the most commonly used drugs. Among 31 patients, three died, nine improved, and nineteen were cured.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The clinical manifestations of severe <jats:italic>Chlamydia psittaci<\/jats:italic> pneumonia are non-specific. The application of mNGS can improve the diagnostic accuracy of <jats:italic>Chlamydia psittaci<\/jats:italic> pneumonia, reduce the unnecessary use of antibiotics, and shorten the course of the disease. Doxycycline-based treatment is effective for severe <jats:italic>chlamydia psittaci<\/jats:italic> pneumonia, but it is necessary to understand the secondary bacterial infection and other complications in the course of the disease.<\/jats:p>","DOI":"10.3389\/fphys.2023.1132724","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T06:59:59Z","timestamp":1675925999000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Physiological analysis of severe chlamydia psittaci pneumonia and clinical diagnosis after doxycycline-based treatment"],"prefix":"10.3389","volume":"14","author":[{"given":"Lujuan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"873","DOI":"10.2147\/IDR.S355024","article-title":"Severe Chlamydia psittaci pneumonia complicated by rhabdomyolysis: A case series[J]","volume":"15","author":"Anbing","year":"2022","journal-title":"Infect. 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