{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:23:33Z","timestamp":1783099413023,"version":"3.54.6"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The two main symptoms at high altitude, sleep abnormalities and cognitive impairments, interact with each other. These two dysfunctions are also closely related to systemic multisystem diseases, including cerebrovascular diseases, psychiatric disorders, and immune regulatory diseases.<\/jats:p><jats:p><jats:bold>Purpose:<\/jats:bold> To systematically analyze and visualize research on sleep disturbances and cognitive impairment at high altitudes using a bibliometrics method, and to determine future research directions by analyzing research trends and the latest hotspots.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Publications from 1990 to 2022 on sleep disturbances and cognitive impairment at high altitudes were retrieved from the Web of Science. Using the R Bibliometrix software and Microsoft Excel, all data were examined statistically and qualitatively. For network visualization, the data were later exported into VOSviewer 1.6.17 and CiteSpace 6.1.R6.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 487 articles in this area were published from 1990 to 2022. In this period, there was an overall increase in the number of publications. The United States has shown considerable importance in this sector. Bloch Konrad E was the most prolific and valuable author. The most prolific journal was High Altitude Medicine &amp;amp; Biology, and it has been the first choice for publishing in this field in recent years. Analysis of keyword co-occurrences suggested that research interest in the clinical manifestations of sleep disturbances and cognitive impairment caused by altitude hypoxia was mainly focused on \u201cacute mountain-sickness,\u201d \u201cinsomnia,\u201d \u201capnea syndrome,\u201d \u201cdepression,\u201d \u201canxiety,\u201d \u201cCheyne-strokes respiration,\u201d and \u201cpulmonary hypertension.\u201d The mechanisms of disease development related to \u201coxidative stress,\u201d \u201cinflammation,\u201d \u201chippocampus,\u201d \u201cprefrontal cortex,\u201d \u201cneurodegeneration,\u201d and \u201cspatial memory\u201d in the brain have been the focus of recent research. According to burst detection analysis, \u201cmood\u201d and \u201cmemory impairment,\u201d as terms with high strength, are expected to remain hot topics in the coming years. High-altitude-induced pulmonary hypertension is also in the emerging stage of research, and the treatments will continue to receive attention in the future.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> More attention is being focused on sleep disturbances and cognitive impairment at high altitudes. This work will serve as a useful reference for the clinical development of treatments for sleep disturbances and cognitive impairment induced by hypobaric hypoxia at high altitudes.<\/jats:p>","DOI":"10.3389\/fphys.2023.1133059","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T06:48:07Z","timestamp":1676270887000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["A bibliometric analysis of the studies in high-altitude induced sleep disturbances and cognitive impairment research"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiexin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hezhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1080\/00207454.2020.1746308","article-title":"The role of mTOR signalling pathway in hypoxia-induced cognitive impairment","volume":"131","author":"Abdo Qaid","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: An R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informetr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1002\/hbm.23635","article-title":"Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude: A panel study","volume":"38","author":"Chen","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"B4","doi-asserted-by":"publisher","first-page":"R317","DOI":"10.1152\/ajpregu.00147.2020","article-title":"The protective role of SOD1 overexpression in central mediation of bradycardia following chronic intermittent hypoxia in mice","volume":"320","author":"Chen","year":"2021","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"5303","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for intellectual turning points: progressive knowledge domain visualization","volume":"101","author":"Chen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1111\/j.1468-1331.2008.02243.x","article-title":"Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areas","volume":"15","author":"Di Paola","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4103\/2045-9912.184717","article-title":"The role of hydrogen sulfide in stroke","volume":"6","author":"Dou","year":"2016","journal-title":"Med. Gas. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1378\/chest.06.2287","article-title":"Central sleep apnea: Pathophysiology and treatment","volume":"131","author":"Eckert","year":"2007","journal-title":"Chest"},{"key":"B9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1183\/09031936.03.00113102","article-title":"Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude","volume":"23","author":"Fischer","year":"2004","journal-title":"Eur. Respir. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0217089","DOI":"10.1371\/journal.pone.0217089","article-title":"Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments","volume":"14","author":"Heinrich","year":"2019","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"zsaa209","DOI":"10.1093\/sleep\/zsaa209","article-title":"Sleep characteristics, cognitive performance, and gray matter volume: findings from the BiDirect study","volume":"44","author":"Hermesdorf","year":"2021","journal-title":"Sleep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.nlm.2008.01.003","article-title":"Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia","volume":"89","author":"Hota","year":"2008","journal-title":"Neurobiol. Learn Mem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.nbd.2008.12.006","article-title":"Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment","volume":"34","author":"Hota","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.freeradbiomed.2010.03.027","article-title":"Oxidative-stress-induced alterations in Sp factors mediate transcriptional regulation of the NR1 subunit in hippocampus during hypoxia","volume":"49","author":"Hota","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.pcad.2010.02.003","article-title":"Acute mountain sickness: pathophysiology, prevention, and treatment","volume":"52","author":"Imray","year":"2010","journal-title":"Prog. Cardiovasc Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1007\/s00221-021-06225-2","article-title":"Cognition effectiveness of continuous positive airway pressure treatment in obstructive sleep apnea syndrome patients with cognitive impairment: a meta-analysis","volume":"239","author":"Jiang","year":"2021","journal-title":"Exp. Brain Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"102237","DOI":"10.1016\/j.eucr.2022.102237","article-title":"Use of hyperbaric oxygen therapy to treat glans penis necrosis after prostatic artery embolization","volume":"45","author":"Johnson-Arbor","year":"2022","journal-title":"Urol. Case Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"R1116","DOI":"10.1016\/j.cub.2015.10.049","article-title":"The hippocampus","volume":"25","author":"Knierim","year":"2015","journal-title":"Curr. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1177\/001872089303500208","article-title":"Cognitive function at high altitude","volume":"35","author":"Kramer","year":"1993","journal-title":"Hum. Factors"},{"key":"B20","doi-asserted-by":"publisher","first-page":"808","DOI":"10.3390\/brainsci12060808","article-title":"Effects of long-term exposure to high altitude hypoxia on cognitive function and its mechanism: A narrative review","volume":"12","author":"Li","year":"2022","journal-title":"Brain Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3233\/rnn-140446","article-title":"Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1\u03b1 pathway","volume":"33","author":"Liu","year":"2015","journal-title":"Restor. Neurol. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2007.06.106","article-title":"Hypobaric hypoxia damages the hippocampal pyramidal neurons in the rat brain","volume":"1175","author":"Maiti","year":"2007","journal-title":"Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbr.2008.01.007","article-title":"Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain","volume":"189","author":"Maiti","year":"","journal-title":"Behav. Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jchemneu.2008.07.003","article-title":"High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum","volume":"36","author":"Maiti","year":"","journal-title":"J. Chem. Neuroanat."},{"key":"B25","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.neubiorev.2017.01.019","article-title":"Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis","volume":"74","author":"McMorris","year":"2017","journal-title":"Neurosci. Biobehav Rev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/bdi.12529","article-title":"Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder","volume":"20","author":"Mukherjee","year":"2018","journal-title":"Bipolar Disord."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2009.03.026","article-title":"Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia","volume":"203","author":"Muthuraju","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3109\/00207454.2011.556279","article-title":"Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats","volume":"121","author":"Muthuraju","year":"2011","journal-title":"Int. J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/jtm.12017","article-title":"Hypoxia-related altitude illnesses","volume":"20","author":"Netzer","year":"2013","journal-title":"J. Travel Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.12659\/msm.905140","article-title":"Role of hypoxia-inducible factors 1\u03b1 (HIF1\u03b1) in SH-SY5Y cell autophagy induced by oxygen-glucose deprivation","volume":"24","author":"Niu","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"B31","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1017\/s1092852921000018","article-title":"Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review","volume":"27","author":"Palagini","year":"2022","journal-title":"CNS Spectr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"Papandreou","year":"2006","journal-title":"Cell Metab."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3389\/fphys.2018.01131","article-title":"Effects on cognitive functioning of acute, subacute and repeated exposures to high altitude","volume":"9","author":"Pun","year":"2018","journal-title":"Front. Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smrv.2017.05.002","article-title":"The role of sleep in regulating structural plasticity and synaptic strength: Implications for memory and cognitive function","volume":"39","author":"Raven","year":"2018","journal-title":"Sleep. Med. Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1089\/ham.2017.0164","article-title":"The 2018 lake louise acute mountain sickness score","volume":"19","author":"Roach","year":"2018","journal-title":"High. Alt. Med. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.18502\/ijph.v49i7.3573","article-title":"Sulfur mustard and immunology; trends of 20 years research in the Web of science core collection: A scientometric review","volume":"49","author":"Salouti","year":"2020","journal-title":"Iran. J. Public Health"},{"key":"B37","doi-asserted-by":"publisher","first-page":"241569","DOI":"10.1155\/2013\/241569","article-title":"Effects of high altitude on sleep and respiratory system and theirs adaptations","volume":"2013","author":"San","year":"2013","journal-title":"Sci. World J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/s0163-1047(05)80023-8","article-title":"Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion","volume":"62","author":"Shukitt-Hale","year":"1994","journal-title":"Behav. Neural Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.3390\/ijerph18041692","article-title":"Pulmonary hypertension in acute and chronic high altitude maladaptation disorders","volume":"18","author":"Sydykov","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.neuroscience.2006.11.037","article-title":"Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats","volume":"145","author":"Titus","year":"2007","journal-title":"Neuroscience"},{"key":"B41","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.physbeh.2015.02.006","article-title":"Acute hypoxic gas breathing severely impairs cognition and task learning in humans","volume":"142","author":"Turner","year":"2015","journal-title":"Physiol. Behav."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s11192-017-2300-7","article-title":"Citation-based clustering of publications using CitNetExplorer and VOSviewer","volume":"111","author":"van Eck","year":"2017","journal-title":"Scientometrics"},{"key":"B43","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1742-7843.2005.pto_139.x","article-title":"Bibliometric methods: Pitfalls and possibilities","volume":"97","author":"Wallin","year":"2005","journal-title":"Basic Clin. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ntt.2012.12.003","article-title":"Effects of acetazolamide on cognitive performance during high-altitude exposure","volume":"35","author":"Wang","year":"2013","journal-title":"Neurotoxicol Teratol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"952399","DOI":"10.3389\/fpsyt.2022.952399","article-title":"Sleep, short-term memory, and mood states of volunteers with increasing altitude","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11011-021-00796-3","article-title":"Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms","volume":"37","author":"Wang","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"k2153","DOI":"10.1136\/bmj.k2153","article-title":"Altitude sickness and acetazolamide","volume":"361","author":"Williamson","year":"2018","journal-title":"Brit Med. J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1089\/ham.2006.7.193","article-title":"High altitude adaptation in Tibetans","volume":"7","author":"Wu","year":"2006","journal-title":"High. Alt. Med. Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1089\/ham.2014.1009","article-title":"Cognitive impairments at high altitudes and adaptation","volume":"15","author":"Yan","year":"2014","journal-title":"High. Alt. Med. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s13104-016-2026-2","article-title":"Tracing the scientific outputs in the field of Ebola research based on publications in the Web of Science","volume":"9","author":"Yi","year":"2016","journal-title":"BMC Res. notes"},{"key":"B51","doi-asserted-by":"publisher","first-page":"915995","DOI":"10.3389\/fnhum.2022.915995","article-title":"The human brain in a high altitude natural environment: A review","volume":"16","author":"Zhang","year":"2022","journal-title":"Front. Hum. Neurosci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1133059\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T06:48:10Z","timestamp":1676270890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1133059\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,13]]},"references-count":51,"alternative-id":["10.3389\/fphys.2023.1133059"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1133059","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,13]]},"article-number":"1133059"}}