{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:39:47Z","timestamp":1788863987295,"version":"build-2803163510"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> In this study, we compared the enhancement of blood vessels and liver parenchyma on enhanced computed tomography (CT) of the upper abdomen with two concentrations of contrast media (400 and 300\u00a0mg I\/mL) based on similar iodine delivery rate (IDR) of 0.88 and 0.9\u00a0g I\/s and iodine load of 450\u00a0mg I\/kg.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We randomly assigned 160 patients into two groups: iomeprol 400\u00a0mg I\/mL (A group) and iohexol 300\u00a0mg I\/mL (B group). The CT attenuation values of the main anatomical structures in the two groups with different scanning phases were measured and the image quality of the two groups was analyzed and compared. The peak pressure and local discomfort (including fever and pain) during contrast medium injection were recorded.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean attenuation value of the abdominal aorta was 313.6 \u00b1 29.6 in the A group and 322.4 \u00b1 30.1 in the B group during the late arterial phase (<jats:italic>p<\/jats:italic> = 0.8). Meanwhile, the mean enhancement values of the portal vein were 176.2 \u00b1 19.3 and 165.9 \u00b1 24.5 in the A and B groups, respectively, during the portal venous phase (<jats:italic>p<\/jats:italic> = 0.6). The mean CT values of liver parenchyma were 117.1 \u00b1 15.3 and 108.8 \u00b1 18.7 in the A and B groups, respectively, during the portal venous phase (<jats:italic>p<\/jats:italic> = 0.9). There was no statistical difference in image quality, peak injection pressure (psi), and local discomfort between the two groups (<jats:italic>p<\/jats:italic> &amp;gt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> When a similar IDR and the same iodine load are used, CT images with different concentrations of contrast media have the same subjective and objective quality, and can meet the diagnostic needs.<\/jats:p>","DOI":"10.3389\/fphys.2023.1141135","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T05:46:19Z","timestamp":1680155179000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["A comparison of the use of contrast media with different iodine concentrations for enhanced computed tomography"],"prefix":"10.3389","volume":"14","author":[{"given":"Yu","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Feng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Bao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"B1","volume-title":"ACR manual on contrast media","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"20170079","DOI":"10.1259\/bjr.20170079","article-title":"Low radiation dose in computed tomography: The role of iodine","volume":"90","author":"Aschoff","year":"2017","journal-title":"Br. J. Radiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1148\/radiol.10090908","article-title":"Intravenous contrast medium administration and scan timing at CT: Considerations and approaches","volume":"256","author":"Bae","year":"2010","journal-title":"Radiology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s00330-014-3540-z","article-title":"Cerebral computed tomography angiography using a 70 kVp protocol: Improved vascular enhancement with a reduced volume of contrast medium and radiation dose","volume":"25","author":"Cho","year":"2015","journal-title":"Eur. Radiol."},{"key":"B5","volume-title":"ESUR contrast media safety guidelines 10.0","year":"2019"},{"key":"B6","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s11547-018-0964-6","article-title":"Diagnostic efficacy of model-based iterative reconstruction algorithm in an assessment of coronary artery in comparison with standard hybrid-iterative reconstruction algorithm: Dose reduction and image quality","volume":"124","author":"Ippolito","year":"2019","journal-title":"Radiol. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3904\/kjim.2014.210","article-title":"Comparison of enhancement and image quality: Different iodine concentrations for liver on 128-slice multidetector computed tomography in the same chronic liver disease patients","volume":"31","author":"Jo","year":"2016","journal-title":"Korean J. Intern Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/RLI.0000000000000019","article-title":"Influence of contrast media viscosity and temperature on injection pressure in computed tomographic angiography: A phantom study","volume":"49","author":"Kok","year":"2014","journal-title":"Invest Radiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1148\/radiol.2017162779","article-title":"Iodixanol versus iopromide at coronary CT angiography: Lumen opacification and effect on heart rhythm-the randomized IsoCOR trial","volume":"286","author":"Lubbers","year":"2018","journal-title":"Radiology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1097\/RLI.0b013e31829979e8","article-title":"Intravascular enhancement with identical iodine delivery rate using different iodine contrast media in a circulation phantom","volume":"48","author":"Mihl","year":"2013","journal-title":"Invest Radiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12410-017-9412-6","article-title":"The updated NICE guidelines: Cardiac CT as the first-line test for coronary artery disease","volume":"10","author":"Moss","year":"2017","journal-title":"Curr. Cardiovasc Imaging Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1007\/s00247-015-3372-2","article-title":"Image quality at low tube voltage (70 kV) and sinogram-affirmed iterative reconstruction for computed tomography in infants with congenital heart disease","volume":"45","author":"Nakagawa","year":"2015","journal-title":"Pediatr. Radiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.ejrad.2014.07.010","article-title":"CT of the abdomen: Degree and quality of enhancement obtained with two concentrations of the same iodinated contrast medium with fixed iodine delivery rate and total iodine load","volume":"83","author":"Paparo","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1016\/j.ejrad.2012.05.017","article-title":"High concentration (400 mgI\/mL) versus low concentration (320 mgI\/mL) iodinated contrast media in multi detector computed tomography of the liver: A randomized, single centre, non-inferiority study","volume":"81","author":"Rengo","year":"2012","journal-title":"Eur. J. Radiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4329\/wjr.v10.i10.135","article-title":"Low-radiation and high image quality coronary computed tomography angiography in \u201creal-world\u201d unselected patients","volume":"10","author":"Richards","year":"2018","journal-title":"World J. Radiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"B5","DOI":"10.1111\/ijcp.12861","article-title":"Did low tube voltage CT combined with low contrast media burden protocols accomplish the goal of \"double low\" for patients? An overview of applications in vessels and abdominal parenchymal organs over the past 5 years","volume":"70","author":"Shen","year":"2016","journal-title":"Int. J. Clin. Pract."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1016\/j.ejrad.2013.09.013","article-title":"Body surface area adapted iopromide 300 mg\/ml versus 370 mg\/ml contrast medium injection protocol: Influence on quantitative and clinical assessment in combined PET\/CT","volume":"82","author":"Verburg","year":"2013","journal-title":"Eur. J. Radiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e4004","DOI":"10.1097\/MD.0000000000004004","article-title":"Double-low protocol for hepatic dynamic CT scan: Effect of low tube voltage and low-dose iodine contrast agent on image quality","volume":"95","author":"Zhang","year":"2016","journal-title":"Med. Baltim."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1141135\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T05:46:22Z","timestamp":1680155182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1141135\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":18,"alternative-id":["10.3389\/fphys.2023.1141135"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1141135","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"article-number":"1141135"}}