{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:12:59Z","timestamp":1782835979921,"version":"3.54.5"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Sepsis-induced acute respiratory distress syndrome (ARDS) was associated with higher mortality. It is unclear whether albumin supplementation early in the course of ARDS can affect the prognostic outcomes of septic shock (SS) patients with ARDS.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The MIMIC-III database was employed to identify SS patients with ARDS. The effect of early application (&amp;lt;24\u00a0h after ICU admission) of human albumin on 28-day mortality in SS patients with ARDS was explored. The propensity score matching was used to minimize the bias between the non-albumin and early albumin treatment groups.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The analysis for all eligible patients who received human albumin showed significantly lower 28-hospital mortality rates than the non-albumin group (37% versus 47%, <jats:italic>p<\/jats:italic> = 0.018). After propensity matching, the difference between the two groups also significantly (34.8% versus 48.1%, <jats:italic>p<\/jats:italic> = 0.031). Moreover, we found that the relationship between albumin use and reduced 28-day mortality was inconsistent across SOFA score subgroups (P<jats:sub>interaction<\/jats:sub> = 0.004, non-adjustment for multiple testing).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Early human albumin administration in SS patients with ARDS was independently associated with a reduction of 28-day mortality. Furthermore, the benefit of human albumin treatment appeared to be more pronounced in patients with a SOFA score of \u2264 10.<\/jats:p>","DOI":"10.3389\/fphys.2023.1142329","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T04:21:07Z","timestamp":1680841267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Early human albumin administration is associated with reduced mortality in septic shock patients with acute respiratory distress syndrome: A retrospective study from the MIMIC-III database"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiya","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1056\/NEJMoa070716","article-title":"Intensive insulin therapy and pentastarch resuscitation in severe sepsis","volume":"358","author":"Brunkhorst","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1056\/NEJMoa1305727","article-title":"Albumin replacement in patients with severe sepsis or septic shock","volume":"370","author":"Caironi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1378\/chest.120.5.1655","article-title":"Pulmonary and extrapulmonary effects of increased colloid osmotic pressure during endotoxemia in rats","volume":"120","author":"Camacho","year":"2001","journal-title":"Chest"},{"key":"B5","first-page":"115","article-title":"EARSS Study Group: Efficacy and tolerance of hyperoncotic albumin administration in septic shock patients: The EARSS study","volume":"37","author":"Charpentier","year":"2011","journal-title":"INTENSIVE CARE Med."},{"key":"B6","first-page":"345","article-title":"Experimentally-induced acute lung injury: The protective effect of hydroxyethyl starch","volume":"36","author":"Di Filippo","year":"2006","journal-title":"Ann. Clin. Lab. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1056\/NEJMoa040232","article-title":"A comparison of albumin and saline for fluid resuscitation in the intensive care unit","volume":"350","author":"Finfer","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s00134-010-2039-6","article-title":"Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis","volume":"37","author":"Finfer","year":"2011","journal-title":"Intensive Care Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"g7620","DOI":"10.1136\/bmj.g7620","article-title":"Intravenous fluid therapy in adult inpatients","volume":"350","author":"Frost","year":"2015","journal-title":"BMJ"},{"key":"B11","doi-asserted-by":"publisher","first-page":"24083","DOI":"10.1038\/s41598-021-03122-0","article-title":"Association between albumin infusion and outcomes in patients with acute kidney injury and septic shock","volume":"11","author":"Ge","year":"2021","journal-title":"Sci. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"E215","DOI":"10.1161\/01.cir.101.23.e215","article-title":"PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals","volume":"101","author":"Goldberger","year":"2000","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"R94","DOI":"10.1186\/11358","article-title":"Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130\/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: The CRYSTMAS study","volume":"16","author":"Guidet","year":"2012","journal-title":"Crit. Care"},{"key":"B14","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1001\/jama.2018.21554","article-title":"Using the E-value to assess the potential effect of unmeasured confounding in observational studies","volume":"321","author":"Haneuse","year":"2019","journal-title":"JAMA"},{"key":"B15","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00134-018-5075-2","article-title":"Albumin infusion improves endothelial function in septic shock patients: A pilot study","volume":"44","author":"Hariri","year":"2018","journal-title":"Intensive Care Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1001\/jama.2017.0131","article-title":"Management of sepsis and septic shock","volume":"317","author":"Howell","year":"2017","journal-title":"JAMA"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1097\/CCM.0b013e3181a00268","article-title":"Effects of hydroxyethyl starch resuscitation on extravascular lung water and pulmonary permeability in sepsis-related acute respiratory distress syndrome","volume":"37","author":"Huang","year":"2009","journal-title":"Crit. Care Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"160035","DOI":"10.1038\/sdata.2016.35","article-title":"MIMIC-III, a freely accessible critical care database","volume":"3","author":"Johnson","year":"2016","journal-title":"Sci. Data"},{"key":"B19","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1001\/jama.2014.5804","article-title":"Hospital deaths in patients with sepsis from 2 independent cohorts","volume":"312","author":"Liu","year":"2014","journal-title":"JAMA"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1097\/00003246-200009000-00001","article-title":"Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group","volume":"28","author":"Mangialardi","year":"2000","journal-title":"Crit. Care Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/01.shk.0000245026.01365.55","article-title":"Pulmonary function is better preserved in pigs when acute normovolemic hemodilution is achieved with hydroxyethyl starch versus lactated Ringer's solution","volume":"27","author":"Margarido","year":"2007","journal-title":"Shock"},{"key":"B22","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1046\/j.1365-2044.1998.00438.x","article-title":"Serum albumin: Touchstone or totem","volume":"53","author":"Margarson","year":"1998","journal-title":"Anaesthesia"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1056\/NEJMoa1901686","article-title":"Early neuromuscular blockade in the acute respiratory distress syndrome","volume":"380","author":"Moss","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00134-010-1843-3","article-title":"Effects of fluids on microvascular perfusion in patients with severe sepsis","volume":"36","author":"Ospina-Tascon","year":"2010","journal-title":"Intensive Care Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"g4561","DOI":"10.1136\/bmj.g4561","article-title":"Randomised trials of human albumin for adults with sepsis: Systematic review and meta-analysis with trial sequential analysis of all-cause mortality","volume":"349","author":"Patel","year":"2014","journal-title":"BMJ"},{"key":"B26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1056\/NEJMoa1204242","article-title":"Hydroxyethyl starch 130\/0.42 versus Ringer's acetate in severe sepsis","volume":"367","author":"Perner","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1001\/jama.2012.5669","article-title":"Acute respiratory distress syndrome: The Berlin definition","volume":"307","author":"Ranieri","year":"2012","journal-title":"JAMA"},{"key":"B28","doi-asserted-by":"publisher","first-page":"g4561","DOI":"10.1136\/bmj.g4561","article-title":"Randomised trials of human albumin for adults with sepsis: Systematic review and meta-analysis with trial sequential analysis of all-cause mortality","volume":"349","author":"Re","year":"2014","journal-title":"Br. Med. J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s00134-012-2472-9","article-title":"Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients","volume":"38","author":"Reinhart","year":"2012","journal-title":"Intensive Care Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1378\/chest.128.5.3098","article-title":"High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury","volume":"128","author":"Sakr","year":"2005","journal-title":"Chest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"R10","DOI":"10.1186\/cc13187","article-title":"Albumin versus crystalloid solutions in patients with the acute respiratory distress syndrome: A systematic review and meta-analysis","volume":"18","author":"Uhlig","year":"2014","journal-title":"Crit. Care"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1097\/CCM.0b013e31819cedfd","article-title":"Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia","volume":"37","author":"van der Heijden","year":"2009","journal-title":"Crit. Care Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: Introducing the E-value","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann. Intern Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/bja\/aei286","article-title":"Effect of fluid loading with saline or colloids on pulmonary permeability, oedema and lung injury score after cardiac and major vascular surgery","volume":"96","author":"Verheij","year":"2006","journal-title":"Br. J. Anaesth."},{"key":"B35","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s00134-016-4326-3","article-title":"Experts' opinion on management of hemodynamics in ARDS patients: Focus on the effects of mechanical ventilation","volume":"42","author":"Vieillard-Baron","year":"2016","journal-title":"Intensive Care Med."},{"key":"B36","first-page":"g4561","article-title":"Double-counted mortality data bias in the 2014 meta-analysis of Patel and coworkers","volume":"349","author":"Wiedermann","year":"2014","journal-title":"Br. Med. J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1056\/NEJMc1405675","article-title":"Albumin replacement in severe sepsis or septic shock","volume":"371","author":"Wiedermann","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1097\/CM9.0000000000001661","article-title":"Expert consensus on the use of human serum albumin in critically ill patients","volume":"134","author":"Yu","year":"2021","journal-title":"Chin. Med. J. Engl."},{"key":"B39","doi-asserted-by":"publisher","first-page":"7","DOI":"10.21037\/atm.2016.08.57","article-title":"Propensity score method: A non-parametric technique to reduce model dependence","volume":"5","author":"Zhang","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2478\/s11658-009-0021-5","article-title":"The anti-apoptotic activity of albumin for endothelium is inhibited by advanced glycation end products restricting intramolecular movement","volume":"14","author":"Zoellner","year":"2009","journal-title":"Cell. Mol. Biol. Lett."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1142329\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T04:21:11Z","timestamp":1680841271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1142329\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,7]]},"references-count":40,"alternative-id":["10.3389\/fphys.2023.1142329"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1142329","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,7]]},"article-number":"1142329"}}