{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:38:17Z","timestamp":1778121497755,"version":"3.51.4"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Hyperthermia impairs various physiological functions and physical performance. We examined the effects of cutaneous administration with an over-the-counter (OTC) analgesic cream containing 20% methyl salicylate and 6% L-menthol during temperate-water immersion (TWI) for exercise-induced hyperthermia.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In a randomized crossover design, twelve healthy males participated in both of two experiments. Firstly, participants underwent a 15-min TWI at 20\u00b0C with (CREAM) or without (CON) cutaneous application of an analgesic cream. Cutaneous vascular conductance (CVC) was measured using laser doppler flowmetry during TWI. In a subsequent experiment, same participants performed a 30-min strenuous interval exercise in a heated (35\u00b0C) environment to induce hyperthermia (~39\u00b0C), which was followed by 15\u00a0min of TWI.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Core body temperature, as measured by an ingestible telemetry sensor, and mean arterial pressure (MAP) were measured. CVC and %CVC (% baseline) were higher during TWI in CREAM than in CON (Condition effect: <jats:italic>p<\/jats:italic> = 0.0053 and <jats:italic>p<\/jats:italic> = 0.0010). An additional experiment revealed that core body heat loss during TWI was greater in CREAM than in CON (Cooling rate: CON 0.070 \u00b1 0.020 vs. CREAM 0.084\u00b0C \u00b1 0.026\u00b0C\/min, <jats:italic>p<\/jats:italic> = 0.0039). A more attenuated MAP response was observed during TWI in CREAM than in CON (Condition effect: <jats:italic>p<\/jats:italic> = 0.0007).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> An OTC analgesic cream containing L-menthol and MS augmented cooling effects when cutaneously applied during TWI in exercise-induced hyperthermia. This was, at least in part, due to the counteractive vasodilatory effect of the analgesic cream. The cutaneous application of OTC analgesic cream may therefore provide a safe, accessible, and affordable means of enhancing the cooling effects of TWI.<\/jats:p>","DOI":"10.3389\/fphys.2023.1161240","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T18:16:44Z","timestamp":1683742604000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men"],"prefix":"10.3389","volume":"14","author":[{"given":"Gang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chansol","family":"Hurr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e12505","DOI":"10.14814\/phy2.12505","article-title":"Does wearing clothing made of a synthetic \"cooling\" fabric improve indoor cycle exercise endurance in trained athletes?","volume":"3","author":"Abdallah","year":"2015","journal-title":"Physiol. 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