{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:35:20Z","timestamp":1786242920270,"version":"build-2736575974"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 DK110332 P30 DK079307"],"award-info":[{"award-number":["K08 DK110332 P30 DK079307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","award":["Carl W. Gottschalk Research Scholar Grant"],"award-info":[{"award-number":["Carl W. 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In these cells, processes implicated as necessary for increased blood pressure include activation of the NLRP3 inflammasome, IL-1\u03b2 production, and oxidative modification of fatty acids such as arachidonic acid, forming isolevuglandins (IsoLGs). We hypothesized that increased blood pressure in response to dietary Mg<jats:sup>2+<\/jats:sup>-depletion leads to increased NLRP3, IL-1\u03b2, and IsoLG production in antigen presenting cells. We found that a Mg<jats:sup>2+<\/jats:sup>-depleted diet (0.01% Mg<jats:sup>2+<\/jats:sup> diet) increased blood pressure in mice compared to mice fed a 0.08% Mg<jats:sup>2+<\/jats:sup> diet. Mg<jats:sup>2+<\/jats:sup>-depleted mice did not exhibit an increase in total body fluid, as measured by quantitative magnetic resonance. Plasma IL-1\u03b2 concentrations were increased (0.13 \u00b1 0.02 pg\/mL vs. 0.04 \u00b1 0.02 pg\/mL). Using flow cytometry, we observed increased NLRP3 and IL-1\u03b2 expression in antigen-presenting cells from spleen, kidney, and aorta. We also observed increased IsoLG production in antigen-presenting cells from these organs. Primary culture of CD11c+ dendritic cells confirmed that low extracellular Mg<jats:sup>2+<\/jats:sup> exerts a direct effect on these cells, stimulating IL-1\u03b2 and IL-18 production. The present findings show that NLRP3 inflammasome activation and IsoLG-adduct formation are stimulated when dietary Mg<jats:sup>2+<\/jats:sup> is depleted. Interventions and increased dietary Mg<jats:sup>2+<\/jats:sup> consumption may prove beneficial in decreasing the prevalence of hypertension and cardiovascular disease.<\/jats:p>","DOI":"10.3389\/fphys.2023.1167904","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T04:28:25Z","timestamp":1684902505000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The role of dietary magnesium deficiency in inflammatory hypertension"],"prefix":"10.3389","volume":"14","author":[{"given":"Ashley","family":"Pitzer Mutchler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritam","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Jamison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet","family":"Kirabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan C.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3130","DOI":"10.1093\/ndt\/gfn236","article-title":"Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population","volume":"23","author":"Baekken","year":"2008","journal-title":"Nephrol. 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