{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:24:08Z","timestamp":1768710248897,"version":"3.49.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Polycystic kidney disease (PKD) is a condition where fluid filled cysts form on the kidney which leads to overall renal failure. Zebrafish has been recently adapted to study polycystic kidney disease, because of its powerful embryology and genetics. However, there are concerns on the conservation of this lower vertebrate in modeling polycystic kidney disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Here, we aim to assess the molecular conservation of zebrafish by searching homologues polycystic kidney disease genes and carrying transcriptome studies in this animal.<\/jats:p><jats:p><jats:bold>Results and Discussion:<\/jats:bold> We found that out of 82 human cystic kidney disease genes, 81 have corresponding zebrafish homologs. While 75 of the genes have a single homologue, only 6 of these genes have two homologs. Comparison of the expression level of the transcripts enabled us to identify one homolog over the other homolog with &amp;gt;70% predominance, which would be prioritized for future experimental studies. Prompted by sexual dimorphism in human and rodent kidneys, we studied transcriptome between different sexes and noted significant differences in male vs. female zebrafish, indicating that sex dimorphism also occurs in zebrafish. Comparison between zebrafish and mouse identified 10% shared genes and 38% shared signaling pathways. String analysis revealed a cluster of genes differentially expressed in male vs. female zebrafish kidneys. In summary, this report demonstrated remarkable molecular conservation, supporting zebrafish as a useful animal model for cystic kidney disease.<\/jats:p>","DOI":"10.3389\/fphys.2023.1184025","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T04:26:13Z","timestamp":1683174373000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Kidney transcriptome and cystic kidney disease genes in zebrafish"],"prefix":"10.3389","volume":"14","author":[{"given":"Matthew","family":"Koslow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1007652","DOI":"10.1371\/journal.pgen.1007652","article-title":"Robust activation of microhomology-mediated end joining for precision gene editing applications","volume":"14","author":"Ata","year":"2018","journal-title":"PLoS Genet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nrneph.2009.90","article-title":"Sexual dimorphism in the aging kidney: Differences in the nitric oxide system","volume":"5","author":"Baylis","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/ng.727","article-title":"The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation","volume":"43","author":"Becker-Heck","year":"2011","journal-title":"Nat. Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","article-title":"Polycystic kidney disease","volume":"4","author":"Bergmann","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1681\/ASN.2019030298","article-title":"ALG9 mutation carriers develop kidney and liver cysts","volume":"30","author":"Besse","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e17047","DOI":"10.7554\/eLife.17047","article-title":"Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling","volume":"5","author":"Calcagni","year":"2016","journal-title":"Elife"},{"key":"B8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.cell.2012.06.028","article-title":"Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling","volume":"150","author":"Chaki","year":"2012","journal-title":"Cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1681\/ASN.2018060590","article-title":"A practical guide for treatment of rapidly progressive ADPKD with tolvaptan","volume":"29","author":"Chebib","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2215\/CJN.00930306","article-title":"Normal values for renal length and volume as measured by magnetic resonance imaging","volume":"2","author":"Cheong","year":"2007","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1093\/ndt\/13.6.1430","article-title":"Differences between women and men with chronic renal disease","volume":"13","author":"Coggins","year":"1998","journal-title":"Nephrol. Dial. Transpl."},{"key":"B12","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.ajhg.2018.03.013","article-title":"Monoallelic mutations to DNAJB11 cause atypical autosomal-dominant polycystic kidney disease","volume":"102","author":"Cornec-Le Gall","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00467-011-1795-z","article-title":"Uncharted waters: Nephrogenesis and renal regeneration in fish and mammals","volume":"26","author":"Davidson","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/dvg.22846","article-title":"Development of the zebrafish mesonephros","volume":"53","author":"Diep","year":"2015","journal-title":"Genesis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e88797","DOI":"10.1172\/jci.insight.88797","article-title":"A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene","volume":"1","author":"Ding","year":"2016","journal-title":"JCI Insight"},{"key":"B16","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1161\/CIRCRESAHA.111.248260","article-title":"Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish","volume":"109","author":"Ding","year":"2011","journal-title":"Circ. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"dmm049427","DOI":"10.1242\/dmm.049427","article-title":"Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy","volume":"16","author":"Ding","year":"2022","journal-title":"Dis. Model Mech."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4655","DOI":"10.1242\/dev.125.23.4655","article-title":"Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function","volume":"125","author":"Drummond","year":"1998","journal-title":"Development"},{"key":"B19","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/sj.ki.5000058","article-title":"The progression of chronic kidney disease: A 10-year population-based study of the effects of gender and age","volume":"69","author":"Eriksen","year":"2006","journal-title":"Kidney Int."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: Summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nrm2278","article-title":"When cilia go bad: Cilia defects and ciliopathies","volume":"8","author":"Fliegauf","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/s0022-2143(96)90081-5","article-title":"Renal expression of a transforming growth factor-alpha transgene accelerates the progression of inherited, slowly progressive polycystic kidney disease in the mouse","volume":"127","author":"Gattone","year":"1996","journal-title":"J. Lab. Clin. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ki.2013.450","article-title":"Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies","volume":"85","author":"Gee","year":"2014","journal-title":"Kidney Int."},{"key":"B24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cell.2009.03.023","article-title":"The vertebrate primary cilium in development, homeostasis, and disease","volume":"137","author":"Gerdes","year":"2009","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"Hildebrandt","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/ng.2681","article-title":"ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3","volume":"45","author":"Hoff","year":"2013","journal-title":"Nat. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"109630","DOI":"10.1016\/j.cellsig.2020.109630","article-title":"Regulation of polycystin expression, maturation and trafficking","volume":"72","author":"Hu","year":"2020","journal-title":"Cell Signal"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5987","DOI":"10.1073\/pnas.1220927110","article-title":"CCDC41 is required for ciliary vesicle docking to the mother centriole","volume":"110","author":"Joo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B31","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12882-020-01946-y","article-title":"Reference values and sex differences in absolute and relative kidney size. A Swiss autopsy study","volume":"21","author":"Kalucki","year":"2020","journal-title":"BMC Nephrol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e104296","DOI":"10.15252\/embj.2019104296","article-title":"Transcriptional repression of NFKBIA triggers constitutive IKK- and proteasome-independent p65\/RelA activation in senescence","volume":"40","author":"Kolesnichenko","year":"2021","journal-title":"EMBO J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1242\/dev.01772","article-title":"Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis","volume":"132","author":"Kramer-Zucker","year":"2005","journal-title":"Development"},{"key":"B35","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2042-6410-4-14","article-title":"Sex differences in kidney gene expression during the life cycle of F344 rats","volume":"4","author":"Kwekel","year":"2013","journal-title":"Biol. Sex. Differ."},{"key":"B36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.kint.2022.02.027","article-title":"The sexual dimorphism of kidney growth in mice and humans","volume":"102","author":"Laouari","year":"2022","journal-title":"Kidney Int."},{"key":"B37","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/s0022-5347(01)64084-9","article-title":"Expression of transforming growth factor alpha and epidermal growth factor receptor in adult polycystic kidney disease","volume":"159","author":"Lee","year":"1998","journal-title":"J. Urol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"6885","DOI":"10.3390\/ijms22136885","article-title":"Coregulation analysis of mechanistic biomarkers in autosomal dominant polycystic kidney disease","volume":"2210","author":"Leierer","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1093\/hmg\/ddt054","article-title":"The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarity","volume":"22","author":"Leightner","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B40","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ajhg.2015.04.023","article-title":"Copy-number variation contributes to the mutational load of bardet-biedl syndrome","volume":"99","author":"Lindstrand","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/ng.3871","article-title":"Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease","volume":"49","author":"Lu","year":"2017","journal-title":"Nat. Genet."},{"key":"B42","doi-asserted-by":"publisher","first-page":"eaay2939","DOI":"10.1126\/sciadv.aay2939","article-title":"Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity","volume":"6","author":"Ma","year":"2020","journal-title":"Sci. Adv."},{"key":"B43","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1080\/15548627.2015.1017179","article-title":"Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide","volume":"11","author":"Macri","year":"2015","journal-title":"Autophagy"},{"key":"B44","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1242\/dmm.003194","article-title":"The ADPKD genes pkd1a\/b and pkd2 regulate extracellular matrix formation","volume":"3","author":"Mangos","year":"2010","journal-title":"Dis. Model Mech."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e51644","DOI":"10.3791\/51644","article-title":"Analysis of nephron composition and function in the adult zebrafish kidney","volume":"90","author":"Mccampbell","year":"2014","journal-title":"J. Vis. Exp."},{"key":"B46","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1053\/j.ajkd.2020.08.012","article-title":"Ciliopathies and the kidney: A review","volume":"77","author":"Mcconnachie","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ebiom.2016.01.027","article-title":"Fatty acid oxidation is impaired in an orthologous mouse model of autosomal dominant polycystic kidney disease","volume":"5","author":"Menezes","year":"2016","journal-title":"EBioMedicine"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1681\/ASN.2004070595","article-title":"Androgen receptor pathway in rats with autosomal dominant polycystic kidney disease","volume":"16","author":"Nagao","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1681\/ASN.V112319","article-title":"Effect of gender on the progression of nondiabetic renal disease: A meta-analysis","volume":"11","author":"Neugarten","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.semnephrol.2022.04.010","article-title":"Sex differences in acute kidney injury","volume":"42","author":"Neugarten","year":"2022","journal-title":"Semin. Nephrol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.ajhg.2016.05.004","article-title":"Mutations in GANAB, encoding the glucosidase II\u03b1 subunit, cause autosomal-dominant polycystic kidney and liver disease","volume":"98","author":"Porath","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B52","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/ki.2010.355","article-title":"Angiogenic growth factors correlate with disease severity in young patients with autosomal dominant polycystic kidney disease","volume":"79","author":"Reed","year":"2011","journal-title":"Kidney Int."},{"key":"B53","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1053\/j.ajkd.2007.10.037","article-title":"Variation in age at ESRD in autosomal dominant polycystic kidney disease","volume":"51","author":"Reed","year":"2008","journal-title":"Am. J. Kidney Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nrm.2017.60","article-title":"Genes and molecular pathways underpinning ciliopathies","volume":"18","author":"Reiter","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"B56","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.1174447","article-title":"A gene network regulating lysosomal biogenesis and function","volume":"325","author":"Sardiello","year":"2009","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.ajhg.2021.11.016","article-title":"Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype","volume":"109","author":"Senum","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"5211","DOI":"10.1093\/hmg\/ddv242","article-title":"Identification of a novel MKS locus defined by TMEM107 mutation","volume":"24","author":"Shaheen","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1161\/CIRCGENETICS.114.000702","article-title":"Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish","volume":"8","author":"Shih","year":"2015","journal-title":"Circ. Cardiovasc Genet."},{"key":"B60","doi-asserted-by":"publisher","first-page":"F404","DOI":"10.1152\/ajprenal.00237.2022","article-title":"Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1","volume":"324","author":"Shillingford","year":"2023","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ng1713","article-title":"The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat","volume":"38","author":"Smith","year":"2006","journal-title":"Nat. Genet."},{"key":"B62","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jgg.2016.02.001","article-title":"Zebrafish as a model for human ciliopathies","volume":"43","author":"Song","year":"2016","journal-title":"J. Genet. Genomics"},{"key":"B63","doi-asserted-by":"publisher","first-page":"i192","DOI":"10.1093\/bioinformatics\/btw277","article-title":"RapMap: A rapid, sensitive and accurate tool for mapping RNA-seq reads to transcriptomes","volume":"32","author":"Srivastava","year":"2016","journal-title":"Bioinformatics"},{"key":"B64","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/s0272-6386(12)80179-x","article-title":"End-stage renal failure appears earlier in men than in women with polycystic kidney disease","volume":"24","author":"Stewart","year":"1994","journal-title":"Am. J. Kidney Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1111\/j.1523-1755.2005.00589.x","article-title":"Gender hormones and the progression of experimental polycystic kidney disease","volume":"68","author":"Stringer","year":"2005","journal-title":"Kidney Int."},{"key":"B66","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ydbio.2007.11.025","article-title":"Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants","volume":"314","author":"Sullivan-Brown","year":"2008","journal-title":"Dev. Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1242\/dev.01240","article-title":"A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney","volume":"131","author":"Sun","year":"2004","journal-title":"Development"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1101\/gad946701","article-title":"vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain","volume":"15","author":"Sun","year":"2001","journal-title":"Genes Dev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: Customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"109701","DOI":"10.1016\/j.cellsig.2020.109701","article-title":"Pathway identification through transcriptome analysis","volume":"74","author":"Terabayashi","year":"2020","journal-title":"Cell Signal"},{"key":"B71","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1681\/ASN.2013040398","article-title":"Strategies targeting cAMP signaling in the treatment of polycystic kidney disease","volume":"25","author":"Torres","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1681\/ASN.2017030295","article-title":"Sexual dimorphic pattern of renal transporters and electrolyte homeostasis","volume":"28","author":"Veiras","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/sj.hdy.6800635","article-title":"Genome evolution and biodiversity in teleost fish","volume":"94","author":"Volff","year":"2005","journal-title":"Hered. (Edinb)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/ng833","article-title":"The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein","volume":"30","author":"Ward","year":"2002","journal-title":"Nat. Genet."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1371\/journal.pgen.0030189","article-title":"The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros","volume":"3","author":"Wingert","year":"2007","journal-title":"PLoS Genet."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1101\/gr.10.12.1903","article-title":"A comparative map of the zebrafish genome","volume":"10","author":"Woods","year":"2000","journal-title":"Genome Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.kint.2023.02.010","article-title":"Drug repurposing in autosomal dominant polycystic kidney disease","volume":"103","author":"Zhou","year":"2023","journal-title":"Kidney Int."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1172\/JCI64401","article-title":"Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease","volume":"123","author":"Zhou","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B79","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1681\/ASN.2020070991","article-title":"Mtor haploinsufficiency ameliorates renal cysts and cilia abnormality in adult zebrafish tmem67 mutants","volume":"32","author":"Zhu","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1093\/hmg\/ddw376","article-title":"Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model","volume":"26","author":"Zhu","year":"2017","journal-title":"Hum. Mol. Genet."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1184025\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T15:24:07Z","timestamp":1684164247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1184025\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":80,"alternative-id":["10.3389\/fphys.2023.1184025"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1184025","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]},"article-number":"1184025"}}