{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:49:51Z","timestamp":1787237391375,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"\n Purpose:<\/jats:bold>\n To compare the morphological characteristics of Schlemm\u2019s canal (SC) in patients with primary open-angle glaucoma (POAG) and healthy controls, using swept-source optical coherence tomography (SS-OCT) with\n en face<\/jats:italic>\n reconstruction.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n In this Prospective comparative study, we included 100 eyes from 50 patients diagnosed with POAG and 50 healthy controls. Three-dimensional cube and line scans of the temporal and nasal quadrants of the anterior segment of the limbus were acquired using SS-OCT. SC was identified using\n en face<\/jats:italic>\n and cross-sectional images. The diameter and area of SC in cross-sectional images and the visible percentage and area of SC in\n en face<\/jats:italic>\n images were measured using ImageJ.\n <\/jats:p>\n \n Results:<\/jats:bold>\n SC was observed in 84% of\n en face<\/jats:italic>\n images and 81% of cross-sectional images in eyes with POAG but in 92% of\n en face<\/jats:italic>\n images and 86% of cross-sectional images in control eyes. Significant differences between the POAG and normal control eyes were found in the\n en face<\/jats:italic>\n area (0.35 \u00b1 0.14\u00a0mm\n 2<\/jats:sup>\n vs. 0.56 \u00b1 0.22\u00a0mm\n 2<\/jats:sup>\n in the temporal quadrant and 0.36 \u00b1 0.14\u00a0mm\n 2<\/jats:sup>\n vs. 0.58 \u00b1 0.23\u00a0mm\n 2<\/jats:sup>\n in the nasal quadrant; both\n p<\/jats:italic>\n &lt; 0.001) and visible percentage of SC (85.71% vs. 94.91% and 87.10% vs. 95.52% in the temporal and nasal quadrant respectively, both\n p<\/jats:italic>\n &lt; 0.001) in\n en face<\/jats:italic>\n images as well as the cross-sectional area (2790.9 \u00b1 942.2\u00a0\u03bcm\n 2<\/jats:sup>\n vs. 4138.6 \u00b1 2027.8\u00a0\u03bcm\n 2<\/jats:sup>\n in the temporal quadrant and 2805.7 \u00b1 947.2\u00a0\u03bcm\n 2<\/jats:sup>\n vs. 4224.0 \u00b1 2002.2\u00a0\u03bcm\n 2<\/jats:sup>\n in the nasal quadrant, both\n p<\/jats:italic>\n &lt; 0.001) and diameter of SC (123.1 \u00b1 25.4\u00a0\u03bcm vs. 149.5 \u00b1 34.7\u00a0\u03bcm in the temporal quadrant and 126.3 \u00b1 28.9\u00a0\u03bcm vs. 155.3 \u00b1 36.0\u00a0\u03bcm in the nasal quadrant, both\n p<\/jats:italic>\n &lt; 0.001) in cross-section images. In addition, the mean intraocular pressure (IOP) significantly correlated with the\n en face<\/jats:italic>\n area, visible percentage of SC, and cross-sectional area in the temporal and nasal quadrants.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n SS-OCT can obtain high-quality\n en face<\/jats:italic>\n images of SC without post-acquisition processing. Eyes with POAG had a decreased\n en face<\/jats:italic>\n SC area compared with normal eyes. A correlation between SC area, visible percentage of\n en face<\/jats:italic>\n images, and IOP was also observed.\n <\/jats:p>","DOI":"10.3389\/fphys.2023.1214427","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T08:24:40Z","timestamp":1698913480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["En face optical coherence tomography detection of Schlemm\u2019s canal in primary open angle glaucoma"],"prefix":"10.3389","volume":"14","author":[{"given":"Haili","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1006\/exer.1996.0012","article-title":"Schlemm\u2019s canal and primary open angle glaucoma: correlation between Schlemm\u2019s canal dimensions and outflow facility","volume":"62","author":"Allingham","year":"1996","journal-title":"Exp. Eye Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.preteyeres.2018.04.002","article-title":"Anterior segment optical coherence tomography","author":"Ang","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"5346","DOI":"10.1167\/iovs.08-1707","article-title":"Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes","volume":"49","author":"Battista","year":"2008","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1167\/iovs.12-10396","article-title":"Expansion of Schlemm\u2019s canal by travoprost in healthy subjects determined by Fourier-domain optical coherence tomography","volume":"54","author":"Chen","year":"2013","journal-title":"Investigative Ophthalmol. Vis. 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Biomaterials"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet. Glob. Health"},{"key":"B27","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1136\/bjophthalmol-2020-318095","article-title":"Choroidal macrovessels: multimodal imaging findings and review of the literature","volume":"106","author":"Gallo","year":"2022","journal-title":"Br J Ophthalmol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1167\/iovs.09-4327","article-title":"Clinical evaluation of the aqueous outflow system in primary open-angle glaucoma for canaloplasty","volume":"51","author":"Grieshaber","year":"2010","journal-title":"Investigative Ophthalmol. Vis. 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