{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:23:23Z","timestamp":1766067803706,"version":"3.41.2"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Background and objective:<\/jats:bold> The G-Branch endograft is a novel multibranched \u201coff-the-shelf\u201d device used to repair thoracoabdominal aortic aneurysms (TAAAs). This report describes the hemodynamic and morphological performance of the G-Branch endograft in a human patient with TAAA.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold> We retrospectively reviewed the computed tomography angiography scans and clinical data of a woman in whom TAAA was treated using a G-Branch endograft. Patient-specific three-dimensional models were reconstructed, and computational fluid dynamics and morphological and hemodynamic indicators were analyzed before and after implantation of the device.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> From a morphological perspective, there was an increase in cross-sectional area in the G-Branch endograft and all bridging stent grafts over time. Blood flow was redistributed among the renovisceral arteries, with a decrease in flow rate in the celiac artery and an increase in the left renal artery. Laminar blood flow was smoother and more rapid after implantation of the G-Branch device and remained stable during follow-up. In the bridging stent grafts, flow recirculation zones were found in the bridging zones of the celiac artery and superior mesenteric artery as well as the distal sealing zones of both renal arteries. Furthermore, higher time-averaged wall shear stress and a lower oscillatory index and relative resident time were found in the G-Branch endograft and bridging stent grafts. Quantitative analysis showed obvious reduction in the surface area ratio of the elevated time-averaged wall shear stress area and surface area ratio of the relative resident time after G-branch implantation.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The revascularization of branch vessels occurred following G-branch implantation, with improvements arising not only from morphological changes but also from hemodynamic alterations. The long-term performance of the G-Branch endograft needs further investigation and clinical validation.<\/jats:p>","DOI":"10.3389\/fphys.2023.1234989","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:22:24Z","timestamp":1691151744000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Aortic hemodynamic and morphological analysis before and after repair of thoracoabdominal aortic aneurysm using a G-Branch endograft"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiabin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongpeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Rong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/ejcts\/ezaa276","article-title":"Anatomical feasibility of a new off-the-shelf inner branch stent graft (E-nside) for endovascular treatment of thoraco-abdominal aneurysms","volume":"58","author":"Bilman","year":"2020","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1115\/1.2796008","article-title":"Steady flow in an aneurysm model: Correlation between fluid dynamics and blood platelet deposition","volume":"118","author":"Bluestein","year":"1996","journal-title":"J. Biomechanical Eng."},{"key":"B3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1023\/A:1009982611386","article-title":"A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques","volume":"15","author":"Critchley","year":"1999","journal-title":"J. Clin. Monit. Comput."},{"key":"B4","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jbiomech.2016.01.031","article-title":"Hemodynamics of left internal mammary artery bypass graft: Effect of anastomotic geometry, coronary artery stenosis, and postoperative time","volume":"49","author":"Fan","year":"2016","journal-title":"J. Biomech."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e059401","DOI":"10.1136\/bmjopen-2021-059401","article-title":"Protocol for GUo\u2019s renovisceral artery reconstruction-1: A prospective, multicentre, single-arm clinical trial to evaluate the safety and efficacy of a multibRANched sTEnt graft systEm for thoracoabdominal aortic aneurysm (GUARANTEE study)","volume":"12","author":"Ge","year":"2022","journal-title":"BMJ Open"},{"key":"B6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ejvs.2013.09.029","article-title":"The hemodynamic impact of misalignment of fenestrated endografts: A computational study","volume":"47","author":"Georgakarakos","year":"2014","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"534.e7","DOI":"10.1016\/j.avsg.2020.08.155","article-title":"Total endovascular repair of complex thoracoabdominal\/abdominal aortic aneurysms with a four-branched off-the-shelf G-BranchTM stent graft","volume":"71","author":"Guo","year":"2021","journal-title":"Ann. Vasc. Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.artres.2009.01.001","article-title":"Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts","volume":"3","author":"Jackson","year":"2009","journal-title":"ARTRES"},{"key":"B9","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1177\/1526602815587261","article-title":"Comparison of blood flow in branched and fenestrated stent-grafts for endovascular repair of abdominal aortic aneurysms","volume":"22","author":"Kandail","year":"2015","journal-title":"J. Endovasc. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ejvs.2018.01.024","article-title":"Early experience with the use of inner branches in endovascular repair of complex abdominal and thoraco-abdominal aortic aneurysms","volume":"55","author":"Katsargyris","year":"2018","journal-title":"Eur. J. Vasc. Endovascular Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e2821","DOI":"10.1002\/cnm.2821","article-title":"A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm","volume":"33","author":"Kelsey","year":"2017","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1016\/j.jvs.2021.05.041","article-title":"Early outcomes of the t-branch off-the-shelf multi-branched stent graft in 542 patients for elective and urgent aortic pathologies: A retrospective observational study","volume":"74","author":"K\u00f6lbel","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1007\/s10439-010-9949-x","article-title":"Quantification of hemodynamics in abdominal aortic aneurysms during rest and exercise using magnetic resonance imaging and computational fluid dynamics","volume":"38","author":"Les","year":"2010","journal-title":"Ann. Biomed. Eng."},{"key":"B14","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/bioengineering10020164","article-title":"Analysis of postoperative remodeling characteristics after modular inner branched stent-graft treatment of aortic arch pathologies using computational fluid dynamics","volume":"10","author":"Li","year":"2023","journal-title":"Bioengineering"},{"key":"B15","doi-asserted-by":"publisher","first-page":"654412","DOI":"10.3389\/fcvm.2021.654412","article-title":"Hemodynamic parameters predict in-stent thrombosis after multibranched endovascular repair of complex abdominal aortic aneurysms: A retrospective study of branched stent-graft thrombosis","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Cardiovasc Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1001\/jama.282.21.2035","article-title":"Hemodynamic shear stress and its role in atherosclerosis","volume":"282","author":"Malek","year":"1999","journal-title":"JAMA"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e3394","DOI":"10.1002\/cnm.3394","article-title":"Retrograde branched extension limb assembling stent of pararenal abdominal aortic aneurysm: A longitudinal hemodynamic analysis for stent graft migration","volume":"36","author":"Mei","year":"2020","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"key":"B18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1017\/S0022112072003003","article-title":"An experimental study of the velocity distribution and transition to turbulence in the aorta","volume":"52","author":"Nerem","year":"1972","journal-title":"J. Fluid Mech."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1001267","DOI":"10.3389\/fcvm.2022.1001267","article-title":"Differential hemodynamics between arteriovenous fistulas with or without intervention before successful use","volume":"9","author":"Northrup","year":"2022","journal-title":"Front. Cardiovasc Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.jvs.2018.10.103","article-title":"Technical aspects and 30-day outcomes of the prospective early feasibility study of the GORE EXCLUDER Thoracoabdominal Branched Endoprosthesis (TAMBE) to treat pararenal and extent IV thoracoabdominal aortic aneurysms","volume":"70","author":"Oderich","year":"2019","journal-title":"J. Vasc. Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/ATVBAHA.119.312687","article-title":"Morphology and hemodynamics in isolated common iliac artery aneurysms impacts proximal aortic remodeling","volume":"39","author":"Parker","year":"2019","journal-title":"ATVB"},{"key":"B22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.medengphy.2019.10.016","article-title":"Hemodynamic consequences of TEVAR with in situ double fenestrations of left carotid artery and left subclavian artery","volume":"76","author":"Qiao","year":"2020","journal-title":"Med. Eng. Phys."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1007\/s10439-008-9561-5","article-title":"Numerical modeling of the flow in intracranial aneurysms: Prediction of regions prone to thrombus formation","volume":"36","author":"Rayz","year":"2008","journal-title":"Ann. Biomed. Eng."},{"key":"B24","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000091648","article-title":"Wall shear stress-an important determinant of endothelial cell function and structure-in the arterial system in vivo. Discrepancies with theory","volume":"43","author":"Reneman","year":"2006","journal-title":"J. Vasc. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.surg.2011.08.012","article-title":"Classification of the celiac axis stenosis owing to median arcuate ligament compression, based on severity of the stenosis with subsequent proposals for management during pancreatoduodenectomy","volume":"151","author":"Sugae","year":"2012","journal-title":"Surgery"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.jvir.2013.04.006","article-title":"Respiration-induced deformations of the superior mesenteric and renal arteries in patients with abdominal aortic aneurysms","volume":"24","author":"Suh","year":"2013","journal-title":"J. Vasc. Interv. Radiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jvs.2015.09.053","article-title":"Impact of alterations in target vessel curvature on branch durability after endovascular repair of thoracoabdominal aortic aneurysms","volume":"63","author":"Sylvan","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1177\/1526602817731096","article-title":"Hemodynamic and anatomic predictors of renovisceral stent-graft occlusion following chimney endovascular repair of juxtarenal aortic aneurysms","volume":"24","author":"Tricarico","year":"2017","journal-title":"J. Endovasc. Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.jvs.2014.11.075","article-title":"Geometry and respiratory-induced deformation of abdominal branch vessels and stents after complex endovascular aneurysm repair","volume":"61","author":"Ullery","year":"2015","journal-title":"J. Vasc. Surg."},{"key":"B30","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/0300-9629(92)90659-E","article-title":"McDonald\u2019s blood flow in arteries; theoretical, experimental and clinical principles","volume":"101","author":"Wurfel","year":"1992","journal-title":"Comp. Biochem. Physiology Part A Physiology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0159836","DOI":"10.1371\/journal.pone.0159836","article-title":"Interplay of proximal flow confluence and distal flow divergence in patient-specific vertebrobasilar system","volume":"11","author":"Yin","year":"2016","journal-title":"PLOS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"100027","DOI":"10.1016\/j.medntd.2020.100027","article-title":"A pilot study of aortic hemodynamics before and after thoracic endovascular repair with a double-branched endograft","volume":"4","author":"Zhu","year":"2019","journal-title":"Med. Nov. Technol. Devices"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1234989\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:22:29Z","timestamp":1691151749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1234989\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":32,"alternative-id":["10.3389\/fphys.2023.1234989"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1234989","relation":{},"ISSN":["1664-042X"],"issn-type":[{"type":"electronic","value":"1664-042X"}],"subject":[],"published":{"date-parts":[[2023,8,4]]},"article-number":"1234989"}}