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Treatments, including selective serotonin reuptake inhibitors, are efficacious in only a small number of patients, which underscores the need to develop novel, efficient treatments. Mitochondrial dysfunction resulting from chronic oxidative stress has been linked with both altered neurotransmitter signaling and the inflammatory response. Hereinafter, we discuss mechanisms by which mitochondrial dysfunction may contribute to the development of PTSD symptoms, and how these may even increase PTSD susceptibility. We also highlight possible therapeutic targets to reduce oxidative stress to prevent or treat PTSD symptoms.<\/jats:p>","DOI":"10.3389\/fphys.2023.1266575","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T02:03:21Z","timestamp":1699927401000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Potential oxidative stress related targets of mitochondria-focused therapy of PTSD"],"prefix":"10.3389","volume":"14","author":[{"given":"Hanna","family":"Kmita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziano","family":"Pinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr I.","family":"Lushchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/biom9110735","article-title":"Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements","volume":"9","author":"Aggarwal","year":"2019","journal-title":"Biomolecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5495","DOI":"10.3390\/ijms22115495","article-title":"The role of HPA Axis and allopregnanolone on the neurobiology of major depressive disorders and PTSD","volume":"22","author":"Almeida","year":"2021","journal-title":"Int. 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