{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:41:36Z","timestamp":1771918896372,"version":"3.50.1"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The annual incidence of non-alcoholic fatty liver disease (NAFLD) continues to rise steadily. In recent years, adipose tissue (AT) has gained recognition as a pivotal contributor to the pathogenesis of NAFLD. Employing bibliometric analysis, we examined literature concerning AT and NAFLD.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Relevant literature on AT in NAFLD from 1980 to 2022 was extracted from the Web of Science Core Collection. These records were visualized using CiteSpace and VOSviewer regarding publications, countries\/regions, institutions, authors, journals, references, and keywords.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Since 2002, a total of 3,330 papers have been included, exhibiting an annual surge in publications. Notably, the quality of publications is superior in the USA and Europe. Kenneth Cusi stands out as the author with the highest number of publications and H-index. <jats:italic>Hepatology<\/jats:italic> is the journal boasting the highest citation and H-index. The University of California System holds the highest centrality among institutions. References specifically delve into physiological processes associated with AT in NAFLD. Currently, lipid metabolism and inflammation constitute the principal research mechanisms in the AT-based regulation of NAFLD, with pertinent keywords including microRNA, T cell, hypoxia, sarcopenia, hepatokine, gut microbiota, and autophagy. The Mediterranean diet is among the most widely recommended dietary approaches for potential NAFLD treatment.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This paper represents the inaugural bibliometric study on the effects of AT on NAFLD, offering valuable insights and directions for future research.<\/jats:p>","DOI":"10.3389\/fphys.2023.1278952","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:50:55Z","timestamp":1703134255000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Frontiers and hotspots of adipose tissue and NAFLD: a bibliometric analysis from 2002 to 2022"],"prefix":"10.3389","volume":"14","author":[{"given":"Shuxiao","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibo","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshuai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinlou","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","author":"Adams","year":"2017","journal-title":"Gut"},{"key":"B2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.dld.2010.05.007","article-title":"Relationship between portal chronic inflammation and disease severity in paediatric non-alcoholic fatty liver disease","volume":"43","author":"Alisi","year":"2011","journal-title":"Dig. Liver Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1042\/cs20030326","article-title":"Increase in long-chain polyunsaturated fatty acid n - 6\/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease","volume":"106","author":"Araya","year":"2004","journal-title":"Clin. Sci. (Lond)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nm1166","article-title":"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB","volume":"11","author":"Cai","year":"2005","journal-title":"Nat. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"5883","DOI":"10.1016\/s0021-9258(19)39445-1","article-title":"Marked acceleration of exogenous fatty acid incorporation into cellular triglycerides by fetuin","volume":"265","author":"Cayatte","year":"1990","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5303","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for intellectual turning points: progressive knowledge domain visualization","volume":"101","author":"Chen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1053\/j.gastro.2012.02.003","article-title":"Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications","volume":"142","author":"Cusi","year":"2012","journal-title":"Gastroenterology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"E1775","DOI":"10.1152\/ajpendo.00624.2006","article-title":"Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes","volume":"292","author":"Cusi","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/jci23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Investig."},{"key":"B12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1053\/j.gastro.2015.05.044","article-title":"Association of adipose tissue inflammation with histologic severity of nonalcoholic fatty liver disease","volume":"149","author":"du Plessis","year":"2015","journal-title":"Gastroenterology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1007\/s11192-015-1645-z","article-title":"The bibliometric analysis of scholarly production: how great is the impact?","volume":"105","author":"Ellegaard","year":"2015","journal-title":"Scientometrics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030","volume":"69","author":"Estes","year":"2018","journal-title":"J. Hepatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1097\/meg.0000000000000736","article-title":"Transient remission of nonalcoholic fatty liver disease decreases the risk of incident type 2 diabetes mellitus in Japanese men","volume":"28","author":"Fukuda","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"101361","DOI":"10.1016\/j.cpcardiol.2022.101361","article-title":"Frontiers and hotspots evolution in psycho-cardiology: a bibliometric analysis from 2004 to 2022","volume":"47","author":"Ge","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jhep.2019.04.013","article-title":"The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content","volume":"71","author":"Gepner","year":"2019","journal-title":"J. Hepatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s00192-018-3604-8","article-title":"Increasing importance of research metrics: journal Impact Factor and h-index","volume":"29","author":"Grech","year":"2018","journal-title":"Int. Urogynecol J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.ecl.2008.07.002","article-title":"The adipocyte as an endocrine cell","volume":"37","author":"Halberg","year":"2008","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"B20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12865-017-0215-y","article-title":"The imbalance of Th17\/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice","volume":"18","author":"He","year":"2017","journal-title":"BMC Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1136\/gutjnl-2015-310027","article-title":"Real friends: faecalibacterium prausnitzii supports mucosal immune homeostasis","volume":"65","author":"Hornef","year":"2016","journal-title":"Gut"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.3390\/nu14142945","article-title":"Specific strains of faecalibacterium prausnitzii ameliorate nonalcoholic fatty liver disease in mice in association with gut microbiota regulation","volume":"14","author":"Hu","year":"2022","journal-title":"Nutrients"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1038\/nature08991","article-title":"Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK\/SIRT1","volume":"464","author":"Iwabu","year":"2010","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.2337\/db11-0174","article-title":"Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice","volume":"60","author":"Jiang","year":"2011","journal-title":"Diabetes"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1210\/clinem\/dgac660","article-title":"Adipose tissue insulin resistance predicts the severity of liver fibrosis in patients with type 2 diabetes and NAFLD","volume":"108","author":"Kalavalapalli","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3390\/cells10051004","article-title":"Adipocyte, immune cells, and miRNA crosstalk: a novel regulator of metabolic dysfunction and obesity","volume":"10","author":"Kiran","year":"2021","journal-title":"Cells"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1080\/15548627.2020.1753002","article-title":"Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice","volume":"17","author":"Ko","year":"2021","journal-title":"Autophagy"},{"key":"B29","doi-asserted-by":"publisher","first-page":"737709","DOI":"10.3389\/fphys.2021.737709","article-title":"Effect of exercise training on fat loss-energetic perspectives and the role of improved adipose tissue function and body fat distribution","volume":"12","author":"Kolnes","year":"2021","journal-title":"Front. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1136\/gutjnl-2015-309265","article-title":"Screening diabetic patients for non-alcoholic fatty liver disease with controlled attenuation parameter and liver stiffness measurements: a prospective cohort study","volume":"65","author":"Kwok","year":"2016","journal-title":"Gut"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s12072-020-10096-0","article-title":"Exosomal miR-199a-5p promotes hepatic lipid accumulation by modulating MST1 expression and fatty acid metabolism","volume":"14","author":"Li","year":"2020","journal-title":"Hepatol. Int."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e83075","DOI":"10.7554\/eLife.83075","article-title":"FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis","volume":"12","author":"Liu","year":"2023","journal-title":"Elife"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1172\/jci57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J. Clin. Investig."},{"key":"B34","doi-asserted-by":"publisher","first-page":"101238","DOI":"10.1016\/j.cpcardiol.2022.101238","article-title":"Frontier and hotspot evolution in cardiorenal syndrome: a bibliometric analysis from 2003 to 2022","volume":"48","author":"Lv","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"734514","DOI":"10.3389\/fcvm.2021.734514","article-title":"A bibliometric analysis of exosomes in cardiovascular diseases from 2001 to 2021","volume":"8","author":"Ma","year":"2021","journal-title":"Front. Cardiovasc Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/mco.0000000000000558","article-title":"Sarcopenic obesity in fatty liver","volume":"22","author":"Merli","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B37","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.cmet.2012.04.004","article-title":"Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease","volume":"15","author":"Min","year":"2012","journal-title":"Cell. Metab."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1111\/j.1572-0241.2005.00297.x","article-title":"Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis","volume":"100","author":"Musso","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"154770","DOI":"10.1016\/j.metabol.2021.154770","article-title":"Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk","volume":"119","author":"Muzurovi\u0107","year":"2021","journal-title":"Metabolism"},{"key":"B40","first-page":"65","article-title":"Adipose tissue inflammation and metabolic dysfunction: role of exercise","volume":"111","author":"Park","year":"2014","journal-title":"Mo Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.1210\/jc.2009-2377","article-title":"Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis","volume":"95","author":"Pasarica","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"Peiseler","year":"2022","journal-title":"J. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.jconrel.2022.03.031","article-title":"Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020","volume":"345","author":"Peng","year":"2022","journal-title":"J. Control Release"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.3390\/nu11122971","article-title":"Mediterranean diet and NAFLD: what we know and questions that still need to Be answered","volume":"11","author":"Plaz Torres","year":"2019","journal-title":"Nutrients"},{"key":"B45","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.metabol.2014.10.012","article-title":"Leptin in nonalcoholic fatty liver disease: a narrative review","volume":"64","author":"Polyzos","year":"2015","journal-title":"Metabolism"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/s0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"B47","doi-asserted-by":"publisher","first-page":"873699","DOI":"10.3389\/fendo.2022.873699","article-title":"Adipokines, hepatokines and myokines: focus on their role and molecular mechanisms in adipose tissue inflammation","volume":"13","author":"Ren","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B48","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ijo.2016.23","article-title":"Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate","volume":"40","author":"Sahuri-Arisoylu","year":"2016","journal-title":"Int. J. Obes. (Lond)"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.jcmgh.2021.07.008","article-title":"White adipose tissue autophagy and adipose-liver crosstalk exacerbate nonalcoholic fatty liver disease in mice","volume":"12","author":"Sakane","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1002\/hep.27284","article-title":"Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition","volume":"60","author":"Sapp","year":"2014","journal-title":"Hepatology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jhep.2022.10.027","article-title":"Changes in abdominal adipose tissue depots assessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis","volume":"78","author":"Shen","year":"2023","journal-title":"J. Hepatol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/md19030148","article-title":"Fucoidan and fucoxanthin attenuate hepatic steatosis and inflammation of NAFLD through modulation of leptin\/adiponectin Axis","volume":"19","author":"Shih","year":"2021","journal-title":"Mar. Drugs"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1172\/jci39228","article-title":"Autophagy regulates adipose mass and differentiation in mice","volume":"119","author":"Singh","year":"2009","journal-title":"J. Clin. Investig."},{"key":"B54","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000282083","article-title":"The role of cytokines in non-alcoholic fatty liver disease","volume":"28","author":"Tilg","year":"2010","journal-title":"Dig. Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3650","DOI":"10.1016\/j.apsb.2022.02.003","article-title":"Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease","volume":"12","author":"Tong","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"B57","doi-asserted-by":"publisher","first-page":"154873","DOI":"10.1016\/j.metabol.2021.154873","article-title":"Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk","volume":"124","author":"van den Hoek","year":"2021","journal-title":"Metabolism"},{"key":"B58","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/hep.22350","article-title":"Visceral fat: a key mediator of steatohepatitis in metabolic liver disease","volume":"48","author":"van der Poorten","year":"2008","journal-title":"Hepatology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1210\/jc.2002-021687","article-title":"Interleukin-6 stimulates lipolysis and fat oxidation in humans","volume":"88","author":"van Hall","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B61","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jcmgh.2020.04.010","article-title":"Diet reversal and immune modulation show key role for liver and adipose tissue T cells in murine nonalcoholic steatohepatitis","volume":"10","author":"Van Herck","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1055\/a-1293-8250","article-title":"Acute elevated resistin exacerbates mitochondrial damage and aggravates liver steatosis through AMPK\/PGC-1\u03b1 signaling pathway in male NAFLD mice","volume":"53","author":"Wen","year":"2021","journal-title":"Horm. Metab. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e3000688","DOI":"10.1371\/journal.pbio.3000688","article-title":"Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice","volume":"18","author":"Xia","year":"2020","journal-title":"PLoS Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1172\/jci19451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J. Clin. Investig."},{"key":"B65","doi-asserted-by":"publisher","first-page":"372","DOI":"10.2337\/db07-1045","article-title":"Serum vaspin concentrations in human obesity and type 2 diabetes","volume":"57","author":"Youn","year":"2008","journal-title":"Diabetes"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1053\/j.gastro.2016.03.005","article-title":"Contribution of alcoholic and nonalcoholic fatty liver disease to the burden of liver-related morbidity and mortality","volume":"150","author":"Younossi","year":"2016","journal-title":"Gastroenterology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1021\/pr100069e","article-title":"Phosphoproteomic biomarkers predicting histologic nonalcoholic steatohepatitis and fibrosis","volume":"9","author":"Younossi","year":"2010","journal-title":"J. Proteome Res."},{"key":"B68","doi-asserted-by":"publisher","first-page":"774030","DOI":"10.3389\/fnut.2021.774030","article-title":"Impact of sarcopenia on the severity of the liver damage in patients with non-alcoholic fatty liver disease","volume":"8","author":"Zambon Azevedo","year":"2021","journal-title":"Front. Nutr."},{"key":"B69","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s12916-022-02525-8","article-title":"The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial","volume":"20","author":"Zelicha","year":"2022","journal-title":"BMC Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.3390\/antiox11122367","article-title":"High-altitude hypoxia exposure induces iron overload and ferroptosis in adipose tissue","volume":"11","author":"Zhang","year":"2022","journal-title":"Antioxidants (Basel)"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1278952\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:50:58Z","timestamp":1703134258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2023.1278952\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":70,"alternative-id":["10.3389\/fphys.2023.1278952"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2023.1278952","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,21]]},"article-number":"1278952"}}