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Physiol."],"abstract":"<jats:p>Metabolic syndromes are characterized by various complications caused by disrupted glucose and lipid metabolism, which are major factors affecting the health of a population. However, existing diagnostic and treatment strategies have limitations, such as the lack of early diagnostic and therapeutic approaches, variability in patient responses to treatment, and cost-effectiveness. Therefore, developing alternative solutions for metabolic syndromes is crucial. N6-methyladenosine (m<jats:sup>6<\/jats:sup>A) is one of the most abundant modifications that determine the fate of RNA. m<jats:sup>6<\/jats:sup>A modifications are closely associated with metabolic syndrome development and present novel prospects for clinical applications. Aberrant m<jats:sup>6<\/jats:sup>A modifications have been detected during inflammatory infiltration, apoptosis, autophagy, iron sagging, necrosis, and scorching during metabolic syndrome pathogenesis and progression. However, few reviews have systematically described the correlation between m<jats:sup>6<\/jats:sup>A modifications and these factors concerning metabolic syndrome pathogenesis and progression. This study summarizes the m<jats:sup>6<\/jats:sup>A methylation regulators and their roles in metabolic syndrome development, highlighting the potential of m<jats:sup>6<\/jats:sup>A modification as a biomarker in metabolic disorders.<\/jats:p>","DOI":"10.3389\/fphys.2024.1271874","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T04:54:50Z","timestamp":1710392090000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["The regulatory role of m6A methylation modification in metabolic syndrome pathogenesis and progression"],"prefix":"10.3389","volume":"15","author":[{"given":"Diwen","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17249","DOI":"10.1021\/jacs.7b09213","article-title":"RNA chemical proteomics reveals the N6-methyladenosine (m6A)-Regulated protein-RNA interactome","volume":"139","author":"Arguello","year":"2017","journal-title":"J. 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