{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:42:55Z","timestamp":1793385775951,"version":"4.5.0"},"reference-count":174,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>In recent years, the emerging phenomenon of ferroptosis has garnered significant attention as a distinctive mode of programmed cell death. Distinguished by its reliance on iron and dependence on reactive oxygen species (ROS), ferroptosis has emerged as a subject of extensive investigation. Mechanistically, this intricate process involves perturbations in iron homeostasis, dampening of system Xc-activity, morphological dynamics within mitochondria, and the onset of lipid peroxidation. Additionally, the concomitant phenomenon of ferritinophagy, the autophagic degradation of ferritin, assumes a pivotal role by facilitating the liberation of iron ions from ferritin, thereby advancing the progression of ferroptosis. This discussion thoroughly examines the detailed cell structures and basic processes behind ferroptosis and ferritinophagy. Moreover, it scrutinizes the intricate web of regulators that orchestrate these processes and examines their intricate interplay within the context of joint disorders. Against the backdrop of an annual increase in cases of osteoarthritis, rheumatoid arthritis, and gout, these narrative sheds light on the intriguing crossroads of pathophysiology by dissecting the intricate interrelationships between joint diseases, ferroptosis, and ferritinophagy. The newfound insights contribute fresh perspectives and promising therapeutic avenues, potentially revolutionizing the landscape of joint disease management.<\/jats:p>","DOI":"10.3389\/fphys.2024.1290234","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:40:53Z","timestamp":1719981653000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Mechanistic elucidation of ferroptosis and ferritinophagy: implications for advancing our understanding of arthritis"],"prefix":"10.3389","volume":"15","author":[{"given":"Caopei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaze","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piaotao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1021\/acschembio.5b00900","article-title":"Five-membered ring peroxide selectively initiates ferroptosis in cancer cells","volume":"11","author":"Abrams","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.tips.2017.02.005","article-title":"Ferroptosis inhibition: mechanisms and opportunities","volume":"38","author":"Angeli","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.chembiol.2020.03.014","article-title":"Achieving life through death: redox biology of lipid peroxidation in ferroptosis","volume":"27","author":"Bay\u0131r","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1136\/ard.44.3.183","article-title":"Effect of intravenous iron dextran on rheumatoid synovitis","volume":"44","author":"Blake","year":"1985","journal-title":"Ann. Rheum. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41419-018-0506-0","article-title":"Ferroptosis-inducing agents compromise in vitro human islet viability and function","volume":"9","author":"Bruni","year":"2018","journal-title":"Cell Death Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e33467","DOI":"10.1371\/journal.pone.0033467","article-title":"Activation of NF-\u03baB\/p65 facilitates early chondrogenic differentiation during endochondral ossification","volume":"7","author":"Caron","year":"2012","journal-title":"PLoS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6779","DOI":"10.1002\/jcp.26405","article-title":"Iron overload induces G1 phase arrest and autophagy in murine preosteoblast cells","volume":"233","author":"Cen","year":"2018","journal-title":"J. Cell Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1038\/s41467-019-09491-5","article-title":"Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-\u03baB pathway","volume":"10","author":"Chang","year":"2019","journal-title":"Nat. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"102703","DOI":"10.1016\/j.redox.2023.102703","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","volume":"62","author":"Cheff","year":"2023","journal-title":"Redox Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"B14","doi-asserted-by":"publisher","first-page":"9781323","DOI":"10.34133\/2022\/9781323","article-title":"Ultrasmall coordination polymers for alleviating ROS-mediated inflammatory and realizing neuroprotection against Parkinson's disease","volume":"2022","author":"Cheng","year":"","journal-title":"Res. (Wash D C)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neuro.2021.11.003","article-title":"Mitochondrial iron metabolism and neurodegenerative diseases","volume":"88","author":"Cheng","year":"","journal-title":"Neurotoxicology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"528","DOI":"10.4103\/1673-5374.266060","article-title":"Ferrostatin-1 protects HT-22 cells from oxidative toxicity","volume":"15","author":"Chu","year":"2020","journal-title":"Neural Regen. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1089\/ars.2006.8.1295","article-title":"Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2","volume":"8","author":"Dasgupta","year":"2006","journal-title":"Antioxid. Redox Signal"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e02523","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"B20","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/s1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ymeth.2007.11.006","article-title":"Morphological assessment of apoptosis","volume":"44","author":"Doonan","year":"2008","journal-title":"Methods"},{"key":"B24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.cmet.2015.09.006","article-title":"Ironing out ferroportin","volume":"22","author":"Drakesmith","year":"2015","journal-title":"Cell Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.3389\/fimmu.2019.01620","article-title":"A novel phytochemical, DIM, inhibits proliferation, migration, invasion and TNF-\u03b1 induced inflammatory cytokine production of synovial fibroblasts from rheumatoid arthritis patients by targeting MAPK and AKT\/mTOR signal pathway","volume":"10","author":"Du","year":"2019","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"121766","DOI":"10.1016\/j.lfs.2023.121766","article-title":"Polydatin ameliorates inflammation and oxidative stress associated with MSU-induced gouty arthritis in mice by regulating PPAR-\u03b3 and ferritin activation","volume":"326","author":"Du","year":"2023","journal-title":"Life Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/rheumatology\/keg402","article-title":"Near-iron deficiency-induced remission of gouty arthritis","volume":"42","author":"Facchini","year":"2003","journal-title":"Rheumatol. Oxf."},{"key":"B28","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","article-title":"Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action","volume":"7","author":"Fang","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13075-018-1668-y","article-title":"The relationship between ferritin and urate levels and risk of gout","volume":"20","author":"Fatima","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e2006203","DOI":"10.1371\/journal.pbio.2006203","article-title":"Unsolved mysteries: how does lipid peroxidation cause ferroptosis?","volume":"16","author":"Feng","year":"2018","journal-title":"PLoS Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.bbrc.2019.10.006","article-title":"Liproxstatin-1 protects the mouse myocardium against ischemia\/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels","volume":"520","author":"Feng","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1478-3231.2011.02732.x","article-title":"Mutant Hras(G12V) and Kras(G12D) have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic mice","volume":"32","author":"Figueiredo","year":"2012","journal-title":"Liver Int."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/art.39618","article-title":"Aging promotes sirtuin 3-dependent cartilage superoxide dismutase 2 acetylation and osteoarthritis","volume":"68","author":"Fu","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"102365","DOI":"10.1016\/j.redox.2022.102365","article-title":"A graphical journey through iron metabolism, microRNAs, and hypoxia in ferroptosis","volume":"54","author":"Fuhrmann","year":"2022","journal-title":"Redox Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"101670","DOI":"10.1016\/j.redox.2020.101670","article-title":"Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis","volume":"36","author":"Fuhrmann","year":"2020","journal-title":"Redox Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e00010-19","DOI":"10.1128\/MCB.00010-19","article-title":"Iron supply via NCOA4-mediated ferritin degradation maintains mitochondrial functions","volume":"39","author":"Fujimaki","year":"2019","journal-title":"Mol. Cell Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1039\/c7mt00143f","article-title":"The transferrin receptor: the cellular iron gate","volume":"9","author":"Gammella","year":"2017","journal-title":"Metallomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO(2) initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/art.37782","article-title":"Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2","volume":"65","author":"Gavriilidis","year":"2013","journal-title":"Arthritis Rheum."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.3390\/antiox11122412","article-title":"Metabolic rewiring toward oxidative phosphorylation disrupts intrinsic resistance to ferroptosis of the colon adenocarcinoma cells","volume":"11","author":"Gotorbe","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1038\/sj.leu.2402238","article-title":"Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug","volume":"15","author":"Gout","year":"2001","journal-title":"Leukemia"},{"key":"B44","doi-asserted-by":"publisher","first-page":"118913","DOI":"10.1016\/j.bbamcr.2020.118913","article-title":"NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells","volume":"1868","author":"Gryzik","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"811","DOI":"10.3389\/fgene.2020.00811","article-title":"Epigenetic regulation mediated by methylation in the pathogenesis and precision medicine of rheumatoid arthritis","volume":"11","author":"Guo","year":"2020","journal-title":"Front. Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fphar.2020.00239","article-title":"Ferroptosis and its potential role in human diseases","volume":"11","author":"Han","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B48","doi-asserted-by":"publisher","first-page":"113915","DOI":"10.1016\/j.biopha.2022.113915","article-title":"Biochanin A protects against iron overload associated knee osteoarthritis via regulating iron levels and NRF2\/System xc-\/GPX4 axis","volume":"157","author":"He","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B49","doi-asserted-by":"publisher","first-page":"108775","DOI":"10.1016\/j.abb.2021.108775","article-title":"Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation","volume":"700","author":"Homma","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"B50","doi-asserted-by":"publisher","first-page":"686155","DOI":"10.3389\/fimmu.2021.686155","article-title":"Promising therapeutic targets for treatment of rheumatoid arthritis","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1093\/jac\/dkl350","article-title":"Deferiprone iron chelation as a novel therapy for experimental mucormycosis","volume":"58","author":"Ibrahim","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"B52","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B53","doi-asserted-by":"publisher","first-page":"594509","DOI":"10.3389\/fcell.2020.594509","article-title":"Iron overload is associated with accelerated progression of osteoarthritis: the role of DMT1 mediated iron homeostasis","volume":"8","author":"Jing","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4968","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1002\/med.21398","article-title":"Targeting programmed cell death using small-molecule compounds to improve potential cancer therapy","volume":"36","author":"Ke","year":"2016","journal-title":"Med. Res. Rev."},{"key":"B57","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2474-15-8","article-title":"Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study","volume":"15","author":"Kennish","year":"2014","journal-title":"BMC Musculoskelet. Disord."},{"key":"B58","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.02.041","article-title":"Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS\/ERK\/Nrf2 signaling pathways in human Osteoarthritis chondrocytes","volume":"106","author":"Khan","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"11722","DOI":"10.1038\/srep11722","article-title":"Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration","volume":"5","author":"Koike","year":"2015","journal-title":"Sci. Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e148671","DOI":"10.1172\/JCI148671","article-title":"Ironing out mechanisms of iron homeostasis and disorders of iron deficiency","volume":"131","author":"Koleini","year":"2021","journal-title":"J. Clin. Invest."},{"key":"B61","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"586578","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"104701","DOI":"10.1016\/j.jbc.2023.104701","article-title":"Oxygen modulates iron homeostasis by switching iron sensing of NCOA4","volume":"299","author":"Kuno","year":"2023","journal-title":"J. Biol. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.bbamcr.2015.01.021","article-title":"Cellular iron uptake, trafficking and metabolism: key molecules and mechanisms and their roles in disease","volume":"1853","author":"Lane","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B65","doi-asserted-by":"publisher","first-page":"17693","DOI":"10.1074\/jbc.M111.300012","article-title":"Oxidatively truncated phospholipids are required agents of tumor necrosis factor \u03b1 (TNF\u03b1)-induced apoptosis","volume":"287","author":"Latchoumycandane","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"B67","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/biology10030184","article-title":"Lipid metabolism and ferroptosis","volume":"10","author":"Lee","year":"2021","journal-title":"Biol. (Basel)."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e69621","DOI":"10.7554\/eLife.69621","article-title":"The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice","volume":"10","author":"Lehrke","year":"2021","journal-title":"Elife"},{"key":"B69","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41422-019-0263-3","article-title":"The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression","volume":"30","author":"Lei","year":"2020","journal-title":"Cell Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fphys.2019.00139","article-title":"Mechanisms of ferroptosis and relations with regulated cell death: a review","volume":"10","author":"Lei","year":"2019","journal-title":"Front. Physiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3999083","DOI":"10.1155\/2022\/3999083","article-title":"Targeting molecular mediators of ferroptosis and oxidative stress for neurological disorders","volume":"2022","author":"Li","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B72","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/nu10020191","article-title":"Markers of iron status are associated with risk of hyperuricemia among Chinese adults: nationwide population-based study","volume":"10","author":"Li","year":"2018","journal-title":"Nutrients"},{"key":"B73","doi-asserted-by":"publisher","first-page":"9838341","DOI":"10.34133\/2022\/9838341","article-title":"Caspase-1 and gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b inflammasome-induced cell death","volume":"2022","author":"Li","year":"","journal-title":"Res. (Wash D C)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1904197","DOI":"10.1002\/adma.201904197","article-title":"Recent progress in ferroptosis inducers for cancer therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e22147","DOI":"10.1096\/fj.202101610R","article-title":"Activation of osteoblast ferroptosis via the METTL3\/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss","volume":"36","author":"Lin","year":"2022","journal-title":"Faseb J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-dependent ferroptosis: machinery and regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3389\/fnins.2018.00632","article-title":"Iron and alzheimer's disease: from pathogenesis to therapeutic implications","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Neurosci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review","volume":"10","author":"Liu","year":"","journal-title":"Ann. Transl. Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2634431","DOI":"10.1155\/2022\/2634431","article-title":"Ferroptosis: a new regulatory mechanism in osteoporosis","volume":"2022","author":"Liu","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s12253-015-9946-3","article-title":"Ferroptosis is involved in acetaminophen induced cell death","volume":"21","author":"L\u0151rincz","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.canlet.2014.11.014","article-title":"The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells","volume":"356","author":"Louandre","year":"2015","journal-title":"Cancer Lett."},{"key":"B82","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3892\/etm.2020.9504","article-title":"Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-\/GPX4 axis","volume":"21","author":"Luo","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e10308","DOI":"10.7554\/eLife.10308","article-title":"Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis","volume":"4","author":"Mancias","year":"2015","journal-title":"Elife"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e0178879","DOI":"10.1371\/journal.pone.0178879","article-title":"Level of inflammatory cytokines in rheumatoid arthritis patients: correlation with 25-hydroxy vitamin D and reactive oxygen species","volume":"12","author":"Mateen","year":"2017","journal-title":"PLoS One"},{"key":"B85","doi-asserted-by":"publisher","first-page":"114048","DOI":"10.1016\/j.biopha.2022.114048","article-title":"Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6\/p-Nrf2\/GPX4 and SIRT6\/NCOA4\/FTH1 pathways","volume":"157","author":"Mi","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B86","doi-asserted-by":"publisher","first-page":"103847","DOI":"10.1016\/j.ebiom.2022.103847","article-title":"Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression","volume":"76","author":"Miao","year":"2022","journal-title":"EBioMedicine"},{"key":"B87","doi-asserted-by":"publisher","first-page":"101328","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"B88","first-page":"195","article-title":"The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis","volume":"7","author":"Mirshafiey","year":"2008","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"B93","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-med-043021-032816","article-title":"Hepcidin and iron in health and disease","volume":"74","author":"Nemeth","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/s41419-022-04628-9","article-title":"Targeting ferroptosis in acute kidney injury","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.phymed.2015.08.002","article-title":"Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells","volume":"22","author":"Ooko","year":"2015","journal-title":"Phytomedicine"},{"key":"B96","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"key":"B97","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"B98","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1039\/c9mt00286c","article-title":"Defining the mechanism of the mitochondrial Atm1p [2Fe-2S] cluster exporter","volume":"12","author":"Pearson","year":"2020","journal-title":"Metallomics"},{"key":"B99","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","article-title":"Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis","volume":"281","author":"Phull","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"B100","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1080\/15548627.2021.1911016","article-title":"Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells","volume":"17","author":"Qin","year":"","journal-title":"Autophagy"},{"key":"B101","doi-asserted-by":"publisher","first-page":"111872","DOI":"10.1016\/j.biopha.2021.111872","article-title":"Ferritinophagy and ferroptosis in cardiovascular disease: mechanisms and potential applications","volume":"141","author":"Qin","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B102","doi-asserted-by":"publisher","first-page":"104919","DOI":"10.1016\/j.phrs.2020.104919","article-title":"The application of ferroptosis in diseases","volume":"159","author":"Qiu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41416-019-0651-y","article-title":"Oncogenic pathways and the electron transport chain: a dangeROS liaison","volume":"122","author":"Raimondi","year":"2020","journal-title":"Br. J. Cancer"},{"key":"B104","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrrheum.2014.32","article-title":"Optimizing current treatment of gout","volume":"10","author":"Rees","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"7718155","DOI":"10.1155\/2023\/7718155","article-title":"Melatonin repairs osteoporotic bone defects in iron-overloaded rats through PI3K\/AKT\/GSK-3\u03b2\/P70S6k signaling pathway","volume":"2023","author":"Ren","year":"2023","journal-title":"Oxid. Med. Cell Longev."},{"key":"B106","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/s0140-6736(87)91771-5","article-title":"Exacerbation of rheumatoid synovitis by iron-dextran infusion","volume":"1","author":"Roberts","year":"1987","journal-title":"Lancet"},{"key":"B107","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/ar3199","article-title":"Epidemiology of gout","volume":"12","author":"Roddy","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B109","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1136\/annrheumdis-2019-216515","article-title":"Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017","volume":"79","author":"Safiri","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"B110","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/s0008-6363(99)00384-3","article-title":"Morphologic and biochemical hallmarks of apoptosis","volume":"45","author":"Saraste","year":"2000","journal-title":"Cardiovasc Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"9882","DOI":"10.1038\/s41598-020-66945-3","article-title":"Serum hepcidin level, iron metabolism and osteoporosis in patients with rheumatoid arthritis","volume":"10","author":"Sato","year":"2020","journal-title":"Sci. Rep."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1073\/pnas.79.6.1889","article-title":"3-Methyladenine: specific inhibitor of autophagic\/lysosomal protein degradation in isolated rat hepatocytes","volume":"79","author":"Seglen","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B113","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1136\/ard.27.1.49","article-title":"Concentration of iron in synovial membrane, synovial fluid, and serum in rheumatoid arthritis and other joint diseases","volume":"27","author":"Senator","year":"1968","journal-title":"Ann. Rheum. Dis."},{"key":"B114","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"13153","DOI":"10.1039\/c7cp00804j","article-title":"Theoretical insights into the mechanism of ferroptosis suppression via inactivation of a lipid peroxide radical by liproxstatin-1","volume":"19","author":"Sheng","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"key":"B116","doi-asserted-by":"publisher","first-page":"e1091059","DOI":"10.1080\/23723556.2015.1091059","article-title":"tRNA synthase suppression activates de novo cysteine synthesis to compensate for cystine and glutathione deprivation during ferroptosis","volume":"3","author":"Shimada","year":"2016","journal-title":"Mol. Cell Oncol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1248\/bpb.b19-00546","article-title":"Dosing time-dependent changes in the anti-tumor effect of xCT inhibitor erastin in human breast cancer xenograft mice","volume":"42","author":"Shiromizu","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1001\/jama.2022.0786","article-title":"What is rheumatoid arthritis?","volume":"327","author":"Smith","year":"2022","journal-title":"Jama"},{"key":"B119","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/ajh.25899","article-title":"Genetic screens reveal CCDC115 as a modulator of erythroid iron and heme trafficking","volume":"95","author":"Sobh","year":"2020","journal-title":"Am. J. Hematol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuroscience.2016.07.003","article-title":"A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-\u03b2 accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload","volume":"332","author":"Sripetchwandee","year":"2016","journal-title":"Neuroscience"},{"key":"B123","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B124","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","article-title":"The chemistry and biology of ferroptosis","volume":"27","author":"Stockwell","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/ph11040137","article-title":"Iron regulation: macrophages in control","volume":"11","author":"Sukhbaatar","year":"2018","journal-title":"Pharm. (Basel)"},{"key":"B126","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","article-title":"JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy","volume":"200","author":"Sun","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"B127","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1042\/bj1920853","article-title":"NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol","volume":"192","author":"Takayanagi","year":"1980","journal-title":"Biochem. J."},{"key":"B128","doi-asserted-by":"publisher","first-page":"4325","DOI":"10.26355\/eurrev_202106_26140","article-title":"Iron metabolism in patients with rheumatoid arthritis","volume":"25","author":"Ta\u0144ski","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.3390\/molecules23123305","article-title":"Overview on the effects of N-acetylcysteine in neurodegenerative diseases","volume":"23","author":"Tardiolo","year":"2018","journal-title":"Molecules"},{"key":"B130","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.3390\/ijms23073612","article-title":"Iron metabolism in aging and age-related diseases","volume":"23","author":"Tian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/path.5248","article-title":"The pathological features of regulated necrosis","volume":"247","author":"Tonnus","year":"2019","journal-title":"J. Pathol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"62160","DOI":"10.1007\/s11356-021-16693-2","article-title":"Free radical biology in neurological manifestations: mechanisms to therapeutics interventions","volume":"29","author":"Tripathi","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1002\/jcb.21717","article-title":"p38\/NF-kB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes","volume":"104","author":"Ulivi","year":"2008","journal-title":"J. Cell Biochem."},{"key":"B134","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr. Biol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"B137","first-page":"6031","article-title":"Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1\/NRF2\/HO-1 pathway","volume":"13","author":"Wang","year":"","journal-title":"Am. J. Transl. Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12011-022-03148-z","article-title":"Circulating level of blood iron and copper associated with inflammation and disease activity of rheumatoid arthritis","volume":"201","author":"Wang","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"B139","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"key":"B140","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J. Adv. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S1875-5364(21)60107-3","article-title":"Therapeutic effect of neohesperidin on TNF-\u03b1-stimulated human rheumatoid arthritis fibroblast-like synoviocytes","volume":"19","author":"Wang","year":"","journal-title":"Chin. J. Nat. Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2307\/3579270","article-title":"Fenton chemistry: an introduction","volume":"145","author":"Wardman","year":"1996","journal-title":"Radiat. Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1042\/BST0391226","article-title":"Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease","volume":"39","author":"Winyard","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"B144","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41467-021-27948-4","article-title":"TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models","volume":"13","author":"Wu","year":"2022","journal-title":"Nat. Commun."},{"key":"B145","doi-asserted-by":"publisher","first-page":"112114","DOI":"10.1016\/j.fct.2021.112114","article-title":"Arsenite induces ferroptosis in the neuronal cells via activation of ferritinophagy","volume":"151","author":"Xiao","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/cells11172726","article-title":"Molecular mechanisms of ferroptosis and relevance to cardiovascular disease","volume":"11","author":"Xie","year":"2022","journal-title":"Cells"},{"key":"B147","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bone.2016.09.023","article-title":"The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss","volume":"94","author":"Xu","year":"2017","journal-title":"Bone"},{"key":"B148","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"B149","doi-asserted-by":"publisher","first-page":"789948","DOI":"10.3389\/fcell.2021.789948","article-title":"Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis","volume":"9","author":"Yang","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1002\/jcp.30039","article-title":"Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis","volume":"236","author":"Yang","year":"","journal-title":"J. Cell Physiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B152","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B153","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"key":"B155","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B156","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1385\/BTER:106:2:123","article-title":"Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis","volume":"106","author":"Yazar","year":"2005","journal-title":"Biol. Trace Elem. Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1021\/acschembio.9b00939","article-title":"Radiation-induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers","volume":"15","author":"Ye","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/jcmm.13008","article-title":"Ferroptosis, a new form of cell death, and its relationships with tumourous diseases","volume":"21","author":"Yu","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"B159","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","article-title":"Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B161","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1016\/j.clnu.2020.01.019","article-title":"Causal associations of iron status with gout and rheumatoid arthritis, but not with inflammatory bowel disease","volume":"39","author":"Yuan","year":"2020","journal-title":"Clin. Nutr."},{"key":"B162","doi-asserted-by":"publisher","first-page":"e13158","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1\u03b1\/SLC7A11 pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"B163","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/s12011-018-1388-9","article-title":"Iron accumulation leads to bone loss by inducing mesenchymal stem cell apoptosis through the activation of Caspase3","volume":"187","author":"Yuan","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"B164","doi-asserted-by":"publisher","first-page":"101510","DOI":"10.1016\/j.arr.2021.101510","article-title":"Iron homeostasis and organismal aging","volume":"72","author":"Zeidan","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"B165","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1111\/bph.14363","article-title":"Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond","volume":"176","author":"Zhang","year":"","journal-title":"Br. J. Pharmacol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.bone.2018.10.005","article-title":"Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms","volume":"120","author":"Zhang","year":"","journal-title":"Bone"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.4103\/1673-5374.274344","article-title":"Neuroprotective effect of deferoxamine on erastininduced ferroptosis in primary cortical neurons","volume":"15","author":"Zhang","year":"2020","journal-title":"Neural Regen. Res."},{"key":"B168","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model","volume":"26","author":"Zhang","year":"","journal-title":"Cell Chem. Biol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000358337","article-title":"High serum ferritin levels increase the risk of hyperuricemia: a cross-sectional and longitudinal study","volume":"64","author":"Zhang","year":"2014","journal-title":"Ann. Nutr. Metab."},{"key":"B170","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"B171","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.apsb.2019.01.015","article-title":"Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-\u03baB\/MAPK signaling and protecting chondrocytes","volume":"9","author":"Zhou","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"B172","doi-asserted-by":"publisher","first-page":"102413","DOI":"10.1016\/j.redox.2022.102413","article-title":"NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells","volume":"55","author":"Zhou","year":"","journal-title":"Redox Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"928321","DOI":"10.3389\/fmolb.2022.928321","article-title":"Ferroptosis in chronic liver diseases: opportunities and challenges","volume":"9","author":"Zhou","year":"","journal-title":"Front. Mol. Biosci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"e148","DOI":"10.1182\/blood-2011-10-388702","article-title":"Prediction of cytogenetic abnormalities with gene expression profiles","volume":"119","author":"Zhou","year":"2012","journal-title":"Blood"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2024.1290234\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:41:05Z","timestamp":1719981665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2024.1290234\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":174,"alternative-id":["10.3389\/fphys.2024.1290234"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2024.1290234","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]},"article-number":"1290234"}}