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The placenta is a highly energy-dependent organ that acts as an intermediary between the mother and foetus and functions to maintain foetal growth and development. Recent studies have demonstrated that mitochondrial dysfunction is associated with placental disorders. Defects in mitochondrial quality control mechanisms may lead to preeclampsia and foetal growth restriction. In this review, we address the quality control mechanisms of mitochondria and the relevant pathologies of mitochondrial dysfunction in placenta-related diseases, such as preeclampsia and foetal growth restriction. This review also investigates the relation between mitochondrial dysfunction and placental disorders.<\/jats:p>","DOI":"10.3389\/fphys.2024.1344951","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T15:27:57Z","timestamp":1707406077000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Mitochondrial quality control alterations and placenta-related disorders"],"prefix":"10.3389","volume":"15","author":[{"given":"Yamei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/membranes12090893","article-title":"Mitochondrial fission and fusion: molecular mechanisms, biological functions, and related disorders","volume":"12","author":"Al Ojaimi","year":"2022","journal-title":"Membranes"},{"key":"B2","doi-asserted-by":"publisher","first-page":"148302","DOI":"10.1016\/j.bbabio.2020.148302","article-title":"The regulation of mitochondrial homeostasis by the ubiquitin proteasome system","volume":"1861","author":"Alsayyah","year":"2020","journal-title":"Biochimica Biophysica Acta-Bioenergetics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1080\/14767058.2018.1532497","article-title":"Maternal serum mitofusin-2 levels in patients with preeclampsia: the possible role of mitochondrial dysfunction in preeclampsia","volume":"33","author":"Aydogan Mathyk","year":"2020","journal-title":"J. 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