{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T11:44:25Z","timestamp":1769255065815,"version":"3.49.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56HL149887 R01HL163666 R03TR004445"],"award-info":[{"award-number":["R56HL149887 R01HL163666 R03TR004445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Cell death is an essential cellular mechanism that ensures quality control and whole-body homeostasis. Various modes of cell death have been studied and detailed. Unbalanced cell death can lead to uncontrolled cell proliferation (i.e., tumors) or excessive loss of cells (i.e., ischemia injury tissue loss). Thus, it is imperative for modes of cell death to be balanced and controlled. Here, we will focus on a recent mode of cell death called pyroptosis. While extensive studies have shown the role of this route of cell death in macrophages and monocytes, evidence for pyroptosis have expanded to encompass other pathologies, including cancer and cardiac diseases. Herein, we provide a brief review on pyroptosis and discuss current gaps in knowledge and scientific advances in cardiac pyroptosis in recent years. Lastly, we provide conclusions and prospective on the relevance to various cardiac diseases.<\/jats:p>","DOI":"10.3389\/fphys.2024.1357285","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T05:01:34Z","timestamp":1712293294000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the role of pyroptosis in the pathogenicity of heart disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Rohail","family":"Bhatti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Y.","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"870924","DOI":"10.3389\/fcvm.2022.870924","article-title":"Cardiac remodeling in heart failure: role of pyroptosis and its therapeutic implications","volume":"9","author":"Chai","year":"2022","journal-title":"Front. Cardiovasc Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1161\/CIRCRESAHA.112.300754","article-title":"Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting","volume":"112","author":"Chen","year":"2013","journal-title":"Circ. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/cr.2016.100","article-title":"Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis","volume":"26","author":"Chen","year":"2016","journal-title":"Cell Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0966-842x(00)01936-3","article-title":"Pro-inflammatory programmed cell death","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1038\/cdd.2014.117","article-title":"Liver X receptor \u03b2 activation induces pyroptosis of human and murine colon cancer cells","volume":"21","author":"Derangere","year":"2014","journal-title":"Cell Death Differ."},{"key":"B8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"101850","DOI":"10.1016\/j.jbc.2022.101850","article-title":"Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection","volume":"298","author":"Dong","year":"2022","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e66234","DOI":"10.1371\/journal.pone.0066234","article-title":"Myocardial ablation of G protein-coupled receptor kinase 2 (GRK2) decreases ischemia\/reperfusion injury through an anti-intrinsic apoptotic pathway","volume":"8","author":"Fan","year":"2013","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41420-021-00428-w","article-title":"SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes","volume":"7","author":"Ferreira","year":"2021","journal-title":"Cell Death Discov."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7123","DOI":"10.1016\/s0021-9258(17)38364-3","article-title":"Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process","volume":"261","author":"Friedlander","year":"1986","journal-title":"J. Biol. Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1038\/sj.cdd.4402148","article-title":"Cell death modalities: classification and pathophysiological implications","volume":"14","author":"Galluzzi","year":"2007","journal-title":"Cell Death Differ."},{"key":"B14","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"B15","doi-asserted-by":"publisher","first-page":"115235","DOI":"10.1016\/j.bcp.2022.115235","article-title":"Therapeutic implications of targeting pyroptosis in Cardiac-related etiology of heart failure","volume":"204","author":"Habimana","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1161\/HYPERTENSIONAHA.122.20004","article-title":"GSDMD (gasdermin D) mediates pathological cardiac hypertrophy and generates a feed-forward amplification cascade via mitochondria-STING (stimulator of interferon genes) Axis","volume":"79","author":"Han","year":"2022","journal-title":"Hypertension"},{"key":"B17","doi-asserted-by":"publisher","first-page":"13775","DOI":"10.1111\/jcmm.15955","article-title":"CXADR-like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction","volume":"24","author":"Han","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1128\/IAI.65.12.5165-5170.1997","article-title":"The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages","volume":"65","author":"Hilbi","year":"1997","journal-title":"Infect. Immun."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1101\/2024.01.12.575466","article-title":"The role of m6A methyltransferase WTAP in inflammatory response of atherosclerosis through NF-\u03baB\/NLRP3 mediated pyroptosis","author":"Hu","year":"2024","journal-title":"bioRxiv"},{"key":"B21","doi-asserted-by":"publisher","first-page":"100337","DOI":"10.1016\/j.labinv.2024.100337","article-title":"Gasdermin D-mediated pyroptosis promotes the development of atherosclerosis","volume":"104","author":"Huang","year":"2024","journal-title":"Lab. Investig."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e151268","DOI":"10.1172\/JCI151268","article-title":"Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction","volume":"132","author":"Jiang","year":"2022","journal-title":"J. Clin. Invest."},{"key":"B23","doi-asserted-by":"publisher","first-page":"657486","DOI":"10.3389\/fphar.2021.657486","article-title":"Caspase-11-Gasdermin D-mediated pyroptosis is involved in the pathogenesis of atherosclerosis","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.chom.2018.05.009","article-title":"Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis","volume":"24","author":"Kang","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B25","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"155219","DOI":"10.1016\/j.prp.2024.155219","article-title":"Pyroptosis-related non-coding RNAs emerging players in atherosclerosis pathology","volume":"255","author":"Khojali","year":"2024","journal-title":"Pathology - Res. Pract."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1038\/s41598-018-21998-3","article-title":"ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171150","article-title":"LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation","volume":"38","author":"Li","year":"2018","journal-title":"Biosci. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41419-020-03120-6","article-title":"GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/nri.2016.151","article-title":"Homeostasis-altering molecular processes as mechanisms of inflammasome activation","volume":"17","author":"Liston","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41419-021-04143-3","article-title":"Pyroptosis inhibition improves the symptom of acute myocardial infarction","volume":"12","author":"Liu","year":"","journal-title":"Cell Death Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"","journal-title":"Nat. Rev. Drug Discov."},{"key":"B33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.3892\/or.2018.6694","article-title":"Biological functions and clinical significance of the newly identified long non-coding RNA RP1-85F18.6 in colorectal cancer","volume":"40","author":"Ma","year":"2018","journal-title":"Oncol. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K\u207a efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Munoz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.jcmgh.2016.03.006","article-title":"NOD-like receptor protein 3 inflammasome priming and activation in barrett's epithelial cells","volume":"2","author":"Nadatani","year":"2016","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3302","DOI":"10.4161\/15384101.2014.949111","article-title":"Cyclin A\/Cdk2 regulates Cdh1 and claspin during late S\/G2 phase of the cell cycle","volume":"13","author":"Oakes","year":"2014","journal-title":"Cell Cycle"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.2174\/0113894501267496231102114410","article-title":"Deciphering the role of pyroptosis impact on cardiovascular diseases","volume":"24","author":"Patil","year":"2023","journal-title":"Curr. Drug Targets"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1038\/s41598-018-20422-0","article-title":"Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells","volume":"8","author":"Pizato","year":"2018","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41575-023-00743-w","article-title":"The gasdermin protein family: emerging roles in gastrointestinal health and disease","volume":"20","author":"Privitera","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/s41419-022-05333-3","article-title":"Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity","volume":"13","author":"Qu","year":"2022","journal-title":"Cell Death Dis."},{"key":"B42","first-page":"603","article-title":"Gasdermins in apoptosis: new players in an old game","volume":"92","author":"Rogers","year":"2019","journal-title":"Yale J. Biol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation","volume":"10","author":"Rogers","year":"2019","journal-title":"Nat. Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux","volume":"45","author":"Ruhl","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"eaau0144","DOI":"10.1126\/scisignal.aau0144","article-title":"Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation","volume":"11","author":"Sato","year":"2018","journal-title":"Sci. Signal"},{"key":"B47","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/tera.1420070306","article-title":"The morphology of various types of cell death in prenatal tissues","volume":"7","author":"Schweichel","year":"1973","journal-title":"Teratology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1161\/CIRCRESAHA.120.318629","article-title":"GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I\/R injury","volume":"129","author":"Shi","year":"2021","journal-title":"Circ. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/82_2016_507","article-title":"IAPs and cell death","volume":"403","author":"Silke","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1038\/s41388-018-0339-4","article-title":"Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense","volume":"37","author":"So","year":"2018","journal-title":"Oncogene"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e36799","DOI":"10.1097\/MD.0000000000036799","article-title":"Identification and validation of pyroptosis-related genes as potential biomarkers for hypertrophic cardiomyopathy: a comprehensive bioinformatics analysis","volume":"103","author":"Tang","year":"2024","journal-title":"Medicine"},{"key":"B54","doi-asserted-by":"publisher","first-page":"118065","DOI":"10.1016\/j.lfs.2020.118065","article-title":"Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer","volume":"257","author":"Tang","year":"2020","journal-title":"Life Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.3389\/fimmu.2018.02842","article-title":"Gasdermin E does not limit apoptotic cell disassembly by promoting early onset of secondary necrosis in jurkat T cells and THP-1 monocytes","volume":"9","author":"Tixeira","year":"2018","journal-title":"Front. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/2503","article-title":"Nonsyndromic hearing impairment is associated with a mutation in DFNA5","volume":"20","author":"Van Laer","year":"1998","journal-title":"Nat. Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1158\/1541-7786.MCR-22-0040","article-title":"Raptinal induces gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma","volume":"20","author":"Vernon","year":"2022","journal-title":"Mol. Cancer Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.7150\/ijbs.24347","article-title":"Alcohol accumulation promotes esophagitis via pyroptosis activation","volume":"14","author":"Wang","year":"","journal-title":"Int. J. Biol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/1751-2980.12576","article-title":"Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins","volume":"19","author":"Wang","year":"","journal-title":"J. Dig. Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/s41467-023-36614-w","article-title":"GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis","volume":"14","author":"Wei","year":"2023","journal-title":"Nat. Commun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s12872-022-02998-8","article-title":"Elevated circulating levels of gasdermin D are related to acute myocardial infarction and pyrogptosis","volume":"22","author":"Weng","year":"2022","journal-title":"BMC Cardiovasc Disord."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e0145404","DOI":"10.1371\/journal.pone.0145404","article-title":"Inflammasome modulation by chemotherapeutics in malignant mesothelioma","volume":"10","author":"Westbom","year":"2015","journal-title":"PLoS One"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e3000047","DOI":"10.1371\/journal.pbio.3000047","article-title":"Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice","volume":"16","author":"Xiao","year":"2018","journal-title":"PLoS Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.trsl.2022.05.001","article-title":"Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage","volume":"248","author":"Ye","year":"2022","journal-title":"Transl. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1340199","DOI":"10.3389\/fcvm.2024.1340199","article-title":"Identification of pyroptosis-associated genes with diagnostic value in calcific aortic valve disease","volume":"11","author":"Yu","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B68","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10495-019-01515-1","article-title":"Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3\/GSDME activation","volume":"24","author":"Zhang","year":"2019","journal-title":"Apoptosis"},{"key":"B69","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s00395-023-01010-4","article-title":"Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia\/reperfusion injury by blocking pyroptotic pore formation","volume":"118","author":"Zhong","year":"2023","journal-title":"Basic Res. Cardiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"108998","DOI":"10.1016\/j.celrep.2021.108998","article-title":"Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases","volume":"35","author":"Zhou","year":"2021","journal-title":"Cell Rep."},{"key":"B71","doi-asserted-by":"publisher","first-page":"21566","DOI":"10.1038\/s41598-022-24879-y","article-title":"The expression pattern of pyroptosis-related genes predicts the prognosis and drug response of melanoma","volume":"12","author":"Zhou","year":"2022","journal-title":"Sci. Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"751533","DOI":"10.3389\/fimmu.2021.751533","article-title":"The versatile gasdermin family: their function and roles in diseases","volume":"12","author":"Zou","year":"2021","journal-title":"Front. Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/358167a0","article-title":"Shigella flexneri induces apoptosis in infected macrophages","volume":"358","author":"Zychlinsky","year":"1992","journal-title":"Nature"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2024.1357285\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T05:01:37Z","timestamp":1712293297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2024.1357285\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":73,"alternative-id":["10.3389\/fphys.2024.1357285"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2024.1357285","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"article-number":"1357285"}}