{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:04:43Z","timestamp":1761563083167,"version":"3.41.2"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>The purpose of this study is to evaluate the impacts of apricot kernels and caffeine on blood glucose, lipid profile, insulin secretion, and antioxidant effect in diabetic rats. Forty adult male albino rats were divided into five groups: normal control, diabetic control, diabetic rats treated with apricot kernels, diabetic rats treated with caffeine, and diabetic rats treated with apricot kernels plus caffeine. Fasting samples were collected at the end of the study for analysis, and pieces of liver and pancreatic tissues were removed for histological analysis. There was a significant decrease in blood glucose, glycated hemoglobin, body weight, total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) levels and a significant increase in insulin and high-density lipoprotein cholesterol (HDL-C) levels in the kernel and caffeine-treated groups. However, there was little histological alteration in the liver or pancreas, and no significant differences were observed in the histological findings between groups. Overall, it can be concluded that apricot kernel and caffeine had a positive effect in decreasing blood glucose and harmful lipid profile and that caffeine had a synergistic effect on the apricot kernel.<\/jats:p>","DOI":"10.3389\/fphys.2024.1358177","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T04:50:40Z","timestamp":1731559840000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats"],"prefix":"10.3389","volume":"15","author":[{"given":"Ahmed El Sayed","family":"Nour El-Deen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Mohamad","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almoatazbellah","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Noaman","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda Samir","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.celrep.2017.04.055","article-title":"Endogenous replication stress in mother cells leads to quiescence of daughter cells","volume":"19","author":"Arora","year":"2017","journal-title":"Cell Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/biof.1831","article-title":"The role of plant\u2010derived natural antioxidants in reduction of oxidative stress","volume":"48","author":"Akbari","year":"2022","journal-title":"Biofactors"},{"key":"B3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/BF02913315","article-title":"Induction of diabetes by streptozotocin in rats","volume":"22","author":"Akbarzadeh","year":"2007","journal-title":"Indian J. 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