{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:03:42Z","timestamp":1781967822902,"version":"3.54.5"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Parturition in dogs is subjected to complex hormonal regulation, with the involvement of prostaglandin F2\u03b1 (PGF2\u03b1) still not fully understood. To investigate uterine inertia (UI), the most prevalent maternal reason for dystocia in the bitch, a better understanding of undisturbed uterine, especially myometrial function, is crucial. Our aim was to gain deeper insights into the role of PGF2\u03b1 in the canine parturient myometrium. Uterine biopsies were obtained during medically indicated cesarean sections. To test for stimulatory effects of PGF2\u03b1 <jats:italic>in vitro<\/jats:italic>, circular and longitudinal myometrial layer tissue strips were challenged with 50\u00a0pM, 0.5\u00a0\u00b5M, and 50\u00a0\u00b5M PGF2\u03b1. <jats:italic>Prostaglandin-endoperoxide synthase<\/jats:italic> 2 (<jats:italic>PTGS2<\/jats:italic>) and <jats:italic>PGF2\u03b1-receptor<\/jats:italic> (<jats:italic>PTGFR<\/jats:italic>) mRNA expressions were compared between primary UI (PUI) and obstructive dystocia (OD) samples in isolated parturient myometrium. PTGFR protein expression was assessed in full thickness uterine samples. PGF2\u03b1 concentrations were analyzed in canine interplacental tissue around term. In the organ bath, the contractile response to PGF2\u03b1 was limited to the circular layer at the highest dosage. Correspondingly, PTGFR immunohistochemical staining was significantly stronger in the circular layer (<jats:italic>p<\/jats:italic> \u2264 0.01). <jats:italic>PTGS2<\/jats:italic> gene expression did not differ between PUI and OD, whereas <jats:italic>PTGFR<\/jats:italic> gene expression could not be quantified. Local uterine PGF2\u03b1 concentrations correlated negatively with serum P4 levels and were the highest during prepartum luteolysis while being significantly lower in PUI. Conclusively, despite the significant increase in local PGF2\u03b1 concentrations at birth, confirming the interplacental tissue as a production site, our results suggest that PGF2\u03b1 might affect uterine contractility during labor, mainly indirectly.<\/jats:p>","DOI":"10.3389\/fphys.2024.1392080","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T07:39:15Z","timestamp":1716881955000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Insights into the role of PGF2\u03b1 in canine periparturient myometrium"],"prefix":"10.3389","volume":"15","author":[{"given":"Carolin","family":"Jungmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Dyhrberg Haubuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Packeiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Margaret","family":"Reichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Mazzuoli-Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Goericke-Pesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1016\/j.theriogenology.2004.09.008","article-title":"Induction of parturition in the bitch with the progesterone-receptor blocker agl\u00e9pristone","volume":"63","author":"Baan","year":"2005","journal-title":"Theriogenology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/1933719109351934","article-title":"Oxytocin pretreatment of pregnant rat myometrium reduces the efficacy of oxytocin but not of ergonovine maleate or prostaglandin F 2 alpha","volume":"17","author":"Balki","year":"2010","journal-title":"Reprod. 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