{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:16:54Z","timestamp":1791415014991,"version":"4.3.3"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Diving decompression theory hypothesizes inflammatory processes as a source of micronuclei which could increase related risks. Therefore, we tested 10 healthy, male divers. They performed 6\u20138 dives with a maximum of two dives per day at depths ranging from 21 to 122\u00a0msw with CCR mixed gas diving.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Post-dive VGE were counted by echocardiography. Saliva and urine samples were taken before and after each dive to evaluate inflammation: ROS production, lipid peroxidation (8-iso-PGF2), DNA damage (8-OH-dG), cytokines (TNF-\u03b1, IL-6, and neopterin).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    VGE exhibits a progressive reduction followed by an increase (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.0001) which parallels inflammation responses. Indeed, ROS, 8-iso-PGF2, IL-6 and neopterin increases from 0.19 \u00b1 0.02 to 1.13 \u00b1 0.09\u00a0\u03bcmol.min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001); 199.8 \u00b1 55.9 to 632.7 \u00b1 73.3\u00a0ng.mg\n                    <jats:sup>\u22121<\/jats:sup>\n                    creatinine (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.0001); 2.35 \u00b1 0.54 to 19.5 \u00b1 2.96\u00a0pg.mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001); and 93.7 \u00b1 11.2 to 299 \u00b1 25.9\u00a0\u03bcmol\u00b7mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    creatinine (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.005), respectively. The variation after each dive was held constant around 158.3% \u00b1 6.9% (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.021); 151.4% \u00b1 5.7% (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.0001); 176.3% \u00b1 11.9% (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.0001); and 160.1% \u00b1 5.6% (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001), respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    When oxy-inflammation reaches a certain level, it exceeds hormetic coping mechanisms allowing second-generation micronuclei substantiated by an increase of VGE after an initial continuous decrease consistent with a depletion of \u201cfirst generation\u201d pre-existing micronuclei.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2024.1395846","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T01:27:10Z","timestamp":1712712430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Physiology of deep closed circuit rebreather mixed gas diving: vascular gas emboli and biological changes during a week-long liveaboard safari"],"prefix":"10.3389","volume":"15","author":[{"given":"Costantino","family":"Balestra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"L\u00e9v\u00eaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Mrakic-Sposta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Vezzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Wauthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Germonpr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Tillmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Laf\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.resp.2018.08.010","article-title":"Taravana, vestibular decompression illness, and autochthonous distal arterial bubbles","volume":"259","author":"Arieli","year":"2019","journal-title":"Respir. 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