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Physiol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> The aim of this study was to investigate the effect of pre-exercise whole-body cryotherapy (WBC) on muscle damage indicators following eccentric treadmill exercise in young women.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty-seven participants underwent two 1-h downhill treadmill runs, replicating 60% of their maximal oxygen uptake, with a 4-week intermission for recovery and treatment application. In this intermission, one group underwent 20 sessions of WBC, delivered five times a week at \u2212120\u00b0C for 3\u00a0min each, while the comparison group received no such treatment. Markers of muscle injury\u2014serum myoglobin concentration, creatine kinase and lactate dehydrogenase activity and also uric acid, and cell-free DNA concentration\u2014were measured before and after downhill runs.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The study observed a notable reduction in post-exercise myoglobin and CK levels in the WBC group after the second running session.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> The results suggest that WBC can have a protective effects against muscle damage resulting from eccentric exercise.<\/jats:p>","DOI":"10.3389\/fphys.2024.1413949","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T05:23:26Z","timestamp":1718774606000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pre-exercise cryotherapy reduces myoglobin and creatine kinase levels after eccentric muscle stress in young women"],"prefix":"10.3389","volume":"15","author":[{"given":"Justyna","family":"Kusmierczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Wiecek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Bawelski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Szygula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Rafa-Zablocka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Kantorowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Szymura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/s41391-021-00321-8","article-title":"Boosting immune response with GM-CSF optimizes primary cryotherapy outcomes in the treatment of prostate cancer: a prospective randomized clinical trial","volume":"24","author":"Barqawi","year":"2021","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"688828","DOI":"10.3389\/FSPOR.2021.688828","article-title":"Cryostimulation for post-exercise recovery in athletes: a consensus and position paper","volume":"3","author":"Bouzigon","year":"2021","journal-title":"Front. 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