{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:46:21Z","timestamp":1792809981809,"version":"4.5.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In multiple trauma patients, the occurrence of trauma-induced coagulopathy (TIC) is closely associated with tissue damage and coagulation function abnormalities in the pathophysiological process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study established a multiple trauma and shock model in Sprague-Dawley (SD) rats and comprehensively utilized histological staining and radiographic imaging techniques to observe injuries in the intestine, liver, skeletal muscles, and bones. Monitoring activated partial thromboplastin time (APTT), platelet (PLT) count, respiratory rate, blood pressure, and other physiological indicators revealed time-dependent alterations in coagulation function and physiological indicators. Enzyme-linked immunosorbent assay (ELISA) measurements of inflammatory factors Tumor Necrosis Factor-alpha (TNF-\u03b1), Interleukin-6 (IL-6) and vascular endothelial injury marker (Syndecan-1) were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Experimental results demonstrated significant changes in tissue structure after multiple traumas, although widespread necrosis or hemorrhagic lesions were not observed. There were time-dependent alterations in coagulation function and physiological indicators. ELISA measurements showed a strong positive correlation between the significant decrease in PLT count and the increase in TNF-\u03b1 and IL-6 concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The study provides crucial information for the early diagnosis and treatment of TIC. The findings suggest that structured monitoring of coagulation and inflammatory indicators can help in understanding the pathophysiological changes and aid in the management of TIC in multiple trauma patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphys.2024.1474707","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T05:50:47Z","timestamp":1730267447000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlations between coagulation abnormalities and inflammatory markers in trauma-induced coagulopathy"],"prefix":"10.3389","volume":"15","author":[{"given":"Ke","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1016\/j.wneu.2020.12.007","article-title":"Coagulation profile as a significant risk factor for short-term complications and mortality after anterior cervical discectomy and fusion","volume":"148","author":"Almeida","year":"2021","journal-title":"World Neurosurg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1055\/a-1311-8264","article-title":"New developments in the pathophysiology and management of primary immune thrombocytopenia","volume":"41","author":"Althaus","year":"2021","journal-title":"Hamostaseologie"},{"key":"B3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1108\/JHOM-05-2019-0139","article-title":"Evaluating complex transformation","volume":"34","author":"Best","year":"2019","journal-title":"J. Health Organ Manag."},{"key":"B4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.anclin.2018.09.004","article-title":"Viscoelastic monitoring to guide the correction of perioperative coagulopathy and massive transfusion in patients with life-threatening hemorrhage","volume":"37","author":"Blaine","year":"2019","journal-title":"Anesthesiol. Clin."},{"key":"B5","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/01.sla.0000256862.79374.31","article-title":"Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?","volume":"245","author":"Brohi","year":"2007","journal-title":"Ann. Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1097\/TA.0b013e318169cd3c","article-title":"Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis","volume":"64","author":"Brohi","year":"2008","journal-title":"J. Trauma"},{"key":"B7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/TA.0000000000004170","article-title":"Trauma-induced coagulopathy: what you need to know","volume":"96","author":"Buzzard","year":"2024","journal-title":"J. Trauma Acute Care Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/gerona\/glz298","article-title":"Bring back the rat","volume":"75","author":"Carter","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s13046-022-02516-w","article-title":"LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer","volume":"41","author":"Cave","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jss.2017.01.008","article-title":"Assessment of three point-of-care platelet function assays in adult trauma patients","volume":"212","author":"Connelly","year":"2017","journal-title":"J. Surg. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1097\/SHK.0b013e31829040e3","article-title":"Acute coagulopathy of trauma in the rat","volume":"39","author":"Darlington","year":"2013","journal-title":"Shock"},{"key":"B12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s10549-021-06280-x","article-title":"Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies","volume":"188","author":"Dempsey","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"B13","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1097\/TA.0000000000001993","article-title":"Acute hyperglycemia exacerbates trauma-induced endothelial and glycocalyx injury: an in vitro model","volume":"85","author":"Diebel","year":"2018","journal-title":"J. Trauma Acute Care Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1055\/s-0039-1701018","article-title":"Traumatic-induced coagulopathy as a systems failure: a new window into hemostasis","volume":"46","author":"Dobson","year":"2020","journal-title":"Semin. Thromb. Hemost."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1089\/thy.2021.0055","article-title":"Effects of thyroid function on hemostasis, coagulation, and fibrinolysis: a mendelian randomization study","volume":"31","author":"Ellervik","year":"2021","journal-title":"Thyroid"},{"key":"B16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.injury.2010.11.003","article-title":"Early coagulopathy in trauma patients: an on-scene and hospital admission study","volume":"43","author":"Floccard","year":"2012","journal-title":"Injury"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1111\/j.1538-7836.2010.03945.x","article-title":"Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations","volume":"8","author":"Frith","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"B18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/ajcp\/aqab153","article-title":"A tale of two approaches","volume":"157","author":"Ghayad","year":"2022","journal-title":"Am. J. Clin. Pathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e23530","DOI":"10.1371\/journal.pone.0023530","article-title":"Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation","volume":"6","author":"Haywood-Watson","year":"2011","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"945","DOI":"10.3390\/jcm9040945","article-title":"Validation of the mTICCS score as a useful tool for the early prediction of a massive transfusion in patients with a traumatic hemorrhage","volume":"9","author":"Horst","year":"2020","journal-title":"J. Clin. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3390\/ijms22020853","article-title":"Immunological dysfunction in tourette syndrome and related disorders","volume":"22","author":"Hsu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1097\/CCM.0000000000004458","article-title":"Coagulopathy of coronavirus disease 2019","volume":"48","author":"Iba","year":"2020","journal-title":"Crit. Care Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/SLA.0b013e318226113d","article-title":"A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients","volume":"254","author":"Johansson","year":"2011","journal-title":"Ann. Surg."},{"key":"B24","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/ta.0b013e31821e0f93","article-title":"High circulating adrenaline levels at admission predict increased mortality after trauma","volume":"72","author":"Johansson","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1055\/s-0039-1701017","article-title":"Platelets and fibrinogen: emerging complexity in trauma-induced coagulopathy","volume":"46","author":"John","year":"2020","journal-title":"Semin. Thromb. Hemost."},{"key":"B26","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12891-023-06338-5","article-title":"Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears","volume":"24","author":"Kajiwara","year":"2023","journal-title":"BMC Musculoskelet. Disord."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1055\/s-0040-1715841","article-title":"Coagulopathy and thrombosis as a result of severe COVID-19 infection: a microvascular focus","volume":"120","author":"Katneni","year":"2020","journal-title":"Thromb. Haemost."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e15350","DOI":"10.14814\/phy2.15350","article-title":"Induction of endothelial barrier dysfunction by serum factors in rats subjected to traumatic brain injury and hemorrhagic shock","volume":"10","author":"Ke","year":"2022","journal-title":"Physiol. Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.3390\/cells11233831","article-title":"Beneficial effects of hyaluronan-based hydrogel implantation after cortical traumatic injury","volume":"11","author":"Lain\u00e9","year":"2022","journal-title":"Cells"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1182\/blood.2019004119","article-title":"Platelets and extracellular vesicles and their cross talk with cancer","volume":"137","author":"Lazar","year":"2021","journal-title":"Blood"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e571","DOI":"10.1097\/HS9.0000000000000571","article-title":"Pathophysiology of coagulopathy in hematological malignancies and in COVID-19","volume":"5","author":"Levi","year":"2021","journal-title":"Hemasphere"},{"key":"B32","doi-asserted-by":"publisher","first-page":"667177","DOI":"10.3389\/fimmu.2021.667177","article-title":"CXCL8 associated dendritic cell activation marker expression and recruitment as indicators of favorable outcomes in colorectal cancer","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ame2.12179","article-title":"Animal models of stroke","volume":"4","author":"Li","year":"2021","journal-title":"Anim. Model Exp. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.3390\/ani12233333","article-title":"Roles of ghrelin and leptin in body mass regulation under food restriction based on the AMPK pathway in the red-backed vole, eothenomys miletus, from kunming and dali regions","volume":"12","author":"Liu","year":"2022","journal-title":"Anim. (Basel)."},{"key":"B35","doi-asserted-by":"publisher","first-page":"5692","DOI":"10.1158\/0008-5472.CAN-20-4226","article-title":"FSTL1 secreted by activated fibroblasts promotes hepatocellular carcinoma metastasis and stemness","volume":"81","author":"Loh","year":"2021","journal-title":"Cancer Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"109055","DOI":"10.1016\/j.cbi.2020.109055","article-title":"Cell fate, metabolic reprogramming and lncRNA of tumor-initiating stem-like cells induced by alcohol","volume":"323","author":"Machida","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"B37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/TA.0000000000003559","article-title":"Traumatic brain injury provokes low fibrinolytic activity in severely injured patients","volume":"93","author":"Meizoso","year":"2022","journal-title":"J. Trauma Acute Care Surg."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1021\/acsbiomaterials.0c01156","article-title":"Development and characterization of a probe device toward intracranial spectroscopy of traumatic brain injury","volume":"7","author":"Mowbray","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1111\/jth.15734","article-title":"Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation","volume":"20","author":"Raghunathan","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"B40","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1080\/19440049.2021.2020913","article-title":"Method development and evaluation for the determination of perfluoroalkyl and polyfluoroalkyl substances in multiple food matrices","volume":"39","author":"Rawn","year":"2022","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"B41","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.thromres.2022.02.016","article-title":"COVID-19 and thrombosis: the role of hemodynamics","volume":"212","author":"Sastry","year":"2022","journal-title":"Thromb. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.5455\/JPMA.33057","article-title":"Evaluation of coagulation factors and serum ferritin in preeclamptic Pakistani women","volume":"70","author":"Shaheen","year":"2020","journal-title":"J. Pak Med. Assoc."},{"key":"B43","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3390\/jcm10040789","article-title":"Primary immune thrombocytopenia: novel insights into pathophysiology and disease management","volume":"10","author":"Singh","year":"2021","journal-title":"J. Clin. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2100864","DOI":"10.1183\/13993003.00864-2021","article-title":"Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis","volume":"59","author":"Song","year":"2022","journal-title":"Eur. Respir. J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1537-2995.2012.03828.x","article-title":"The clinical significance of platelet counts in the first 24 hours after severe injury","volume":"53","author":"Stansbury","year":"2013","journal-title":"Transfusion"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1182\/blood.2019003977","article-title":"Aspirin and antiplatelet treatments in cancer","volume":"137","author":"Tao","year":"2021","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1136\/emj.2009.088484","article-title":"Drivers of acute coagulopathy after severe trauma: a multivariate analysis of 1987 patients","volume":"27","author":"Wafaisade","year":"2010","journal-title":"Emerg. Med. J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jss.2011.04.047","article-title":"Hemodilution is not critical in the pathogenesis of the acute coagulopathy of trauma","volume":"173","author":"Wohlauer","year":"2012","journal-title":"J. Surg. Res."},{"key":"B49","first-page":"6805","article-title":"Multivariate logistic regression analysis of preeclampsia in patients with pregnancy induced hypertension and the risk predictive value of monitoring platelet, coagulation function and thyroid hormone in pregnant women","volume":"14","author":"Zeng","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1093\/neuonc\/noad003","article-title":"Histological and molecular classifications of pediatric glioma with time-dependent diffusion MRI-based microstructural mapping","volume":"25","author":"Zhang","year":"2023","journal-title":"Neuro Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jare.2021.06.007","article-title":"Characteristics of sensory innervation in synovium of rats within different knee osteoarthritis models and the correlation between synovial fibrosis and hyperalgesia","volume":"35","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12974-022-02480-4","article-title":"Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance","volume":"19","author":"Zheng","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/TA.0000000000003464","article-title":"Thromboelastometry fails to detect autoheparinization after major trauma and hemorrhagic shock","volume":"92","author":"Zipperle","year":"2022","journal-title":"J. Trauma Acute Care Surg."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2024.1474707\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T05:50:49Z","timestamp":1730267449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2024.1474707\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":53,"alternative-id":["10.3389\/fphys.2024.1474707"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2024.1474707","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]},"article-number":"1474707"}}