{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T18:30:42Z","timestamp":1775932242410,"version":"3.50.1"},"reference-count":106,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Mitochondria are essential organelles responsible for cellular energy supply. The maintenance of mitochondrial structure and function relies heavily on quality control systems, including biogenesis, fission, and fusion. Mitochondrial fusion refers to the interconnection of two similar mitochondria, facilitating the exchange of mitochondrial DNA, metabolic substrates, proteins, and other components. This process is crucial for rescuing damaged mitochondria and maintaining their normal function. In mammals, mitochondrial fusion involves two sequential steps: outer membrane fusion, regulated by mitofusin 1 and 2 (MFN1\/2), and inner membrane fusion, mediated by optic atrophy 1 (OPA1). Dysfunction in mitochondrial fusion has been implicated in the development of various acute and chronic lung injuries. Regulating mitochondrial fusion, maintaining mitochondrial dynamics, and improving mitochondrial function are effective strategies for mitigating lung tissue and cellular damage. This study reviews the expression and regulatory mechanisms of mitochondrial fusion proteins in lung injuries of different etiologies, explores their relationship with lung injury diseases, and offers a theoretical foundation for developing novel therapeutic approaches targeting mitochondrial fusion proteins in lung injury.<\/jats:p>","DOI":"10.3389\/fphys.2025.1500247","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:13:41Z","timestamp":1742368421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Mitochondrial fusion protein: a new therapeutic target for lung injury diseases"],"prefix":"10.3389","volume":"16","author":[{"given":"Guiyang","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianxia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102012","DOI":"10.1016\/j.jsps.2024.102012","article-title":"A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: implications for cellular health and diseases","volume":"32","author":"Alghamdi","year":"2024","journal-title":"Saudi Pharm. J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"L895","DOI":"10.1152\/ajplung.00180.2014","article-title":"Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells","volume":"307","author":"allweg","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"606678","DOI":"10.3389\/fmed.2021.606678","article-title":"Hyperoxia and lungs: what we have learned from animal models","volume":"8","author":"Amarelle","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1038\/s41467-018-05387-y","article-title":"Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production","volume":"9","author":"Amini","year":"2018","journal-title":"Nat. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"6644002","DOI":"10.1155\/2021\/6644002","article-title":"Oxidative stress-derived mitochondrial dysfunction in chronic obstructive pulmonary disease: a concise review","volume":"12","author":"Antunes","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"L840","DOI":"10.1152\/ajplung.00155.2013","article-title":"Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle","volume":"306","author":"Aravamudan","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/jcp.25508","article-title":"Functional effects of cigarette smoke-induced changes in airway smooth muscle mitochondrial morphology","volume":"232","author":"Aravamudan","year":"2017","journal-title":"J. Cell Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1290046","DOI":"10.3389\/fcell.2023.1290046","article-title":"Mitochondrial quality control in health and cardiovascular diseases","volume":"11","author":"Atici","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3390\/antiox10091400","article-title":"Intermittent hypoxia-hyperoxia and oxidative stress in developing human airway smooth muscle","volume":"10","author":"Bartman","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00441-022-03602-3","article-title":"Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction","volume":"388","author":"Bhat","year":"2022","journal-title":"Cell Tissue Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nature21077","article-title":"MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion","volume":"542","author":"Cao","year":"2017","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1006","DOI":"10.1016\/S2468-2667(23)00242-6","article-title":"Tobacco control in China","volume":"8","author":"Chan","year":"2023","journal-title":"Lancet Public Health"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1111\/bph.12179","article-title":"Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study","volume":"169","author":"Chitra","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.resp.2013.12.007","article-title":"Altered mitochondrial biogenesis and its fusion gene expression is involved in the high-altitude adaptation of rat lung","volume":"192","author":"Chitra","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s12916-022-02629-1","article-title":"Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD","volume":"20","author":"Cho","year":"2022","journal-title":"BMC Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3390","DOI":"10.1038\/s41467-019-11327-1","article-title":"Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis","volume":"10","author":"Chung","year":"2019","journal-title":"Nat. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.bbabio.2018.01.005","article-title":"Eight human OPA1 isoforms, long and short: what are they for?","volume":"1859","author":"Del Dotto","year":"2018","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"L137","DOI":"10.1152\/ajplung.00305.2020","article-title":"TNF\u03b1 induces mitochondrial fragmentation and biogenesis in human airway smooth muscle","volume":"320","author":"Delmotte","year":"2021","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.00375.2021","article-title":"Long-term complications of COVID-19","volume":"322","author":"Desai","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.intimp.2018.10.012","article-title":"Protective effects of hydrogen gas against sepsis-induced acute lung injury via regulation of mitochondrial function and dynamics","volume":"65","author":"Dong","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1165\/rcmb.2021-0512OC","article-title":"Cytidine 5'-diphosphocholine corrects alveolar type II cell mitochondrial dysfunction in influenza-infected mice","volume":"66","author":"Doolittle","year":"2022","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.tcb.2020.09.008","article-title":"Mitochondrial fusion: the machineries in and out","volume":"31","author":"Gao","year":"2021","journal-title":"Trends Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"L737","DOI":"10.1152\/ajplung.00146.2013","article-title":"Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence","volume":"305","author":"Hara","year":"2013","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/s41419-020-03152-y","article-title":"OPA1 and MICOS Regulate mitochondrial crista dynamics and formation","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"139923","DOI":"10.1016\/j.scitotenv.2020.139923","article-title":"GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients","volume":"739","author":"Huang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1161\/CIRCRESAHA.123.322914","article-title":"Mitofusin-2 regulates platelet mitochondria and function","volume":"134","author":"Jacob","year":"2024","journal-title":"Circ. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e14045","DOI":"10.7717\/peerj.14045","article-title":"Cinnamaldehyde regulates mitochondrial quality against hydrogen peroxide induced apoptosis in mouse lung mesenchymal stem cells via the PINK1\/Parkin signaling pathway","volume":"10","author":"Ke","year":"2022","journal-title":"PeerJ"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1038\/s41467-021-23047-6","article-title":"Mitofusin-2 stabilizes adherens junctions and suppresses endothelial inflammation via modulation of \u03b2-catenin signaling","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1186\/s12931-023-02634-9","article-title":"Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease","volume":"24","author":"Li","year":"","journal-title":"Respir. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.21037\/jtd-22-315","article-title":"Role of TRPA1\/TRPV1 in acute ozone exposure induced murine model of airway inflammation and bronchial hyperresponsiveness","volume":"14","author":"Li","year":"","journal-title":"J. Thorac. Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"12337","DOI":"10.3390\/ijms232012337","article-title":"Role of macrophages in air pollution exposure related asthma","volume":"23","author":"Li","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1007\/s11596-020-2305-y","article-title":"Mitofusion 2 overexpression decreased proliferation of human embryonic lung fibroblasts in acute respiratory distress syndrome through inhibiting RAS-RAF-1-ERK1\/2 pathway","volume":"40","author":"Li","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e902","DOI":"10.1002\/ctm2.902","article-title":"Regulatory roles of external cholesterol in human airway epithelial mitochondrial function through STARD3 signalling","volume":"12","author":"Li","year":"","journal-title":"Clin. Transl. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"113595","DOI":"10.1016\/j.ecoenv.2022.113595","article-title":"Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction","volume":"238","author":"Li","year":"","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B39","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1186\/s12890-022-02191-9","article-title":"Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2\/PINK1 pathway","volume":"22","author":"Li","year":"","journal-title":"BMC Pulm. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1021\/tx5003723","article-title":"Effect of ambient PM(2.5) on lung mitochondrial damage and fusion\/fission gene expression in rats","volume":"28","author":"Li","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1029775","DOI":"10.3389\/fphar.2022.1029775","article-title":"Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction","volume":"13","author":"Li","year":"","journal-title":"Front. Pharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"154545","DOI":"10.1016\/j.phymed.2022.154545","article-title":"Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-\u03baB and MAPK pathways in LPS-induced ALI and inflammation models","volume":"108","author":"Li","year":"","journal-title":"Phytomedicine"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3389\/fimmu.2018.01477","article-title":"High tidal volume induces mitochondria damage and releases mitochondrial DNA to aggravate the ventilator-induced lung injury","volume":"9","author":"Lin","year":"2018","journal-title":"Front. Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"171396","DOI":"10.1016\/j.scitotenv.2024.171396","article-title":"Atmospheric fine particulate matter (PM2.5) induces pulmonary fibrosis by regulating different cell fates via autophagy","volume":"923","author":"Liu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e23127","DOI":"10.1002\/jbt.23127","article-title":"Mitoquinone mitigates paraquat-induced A549 lung epithelial cell injury by promoting MFN1\/MFN2-mediated mitochondrial fusion","volume":"36","author":"Liu","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.bbrc.2019.04.164","article-title":"Protective effect of agmatine against hyperoxia-induced acute lung injury via regulating lncRNA gadd7","volume":"516","author":"Liu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.4081\/ejh.2023.3535","article-title":"LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury","volume":"67","author":"Liu","year":"","journal-title":"Eur. J. Histochem"},{"key":"B48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12989-023-00534-w","article-title":"Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion","volume":"20","author":"Liu","year":"","journal-title":"Part Fibre Toxicol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"117780","DOI":"10.1016\/j.jep.2024.117780","article-title":"Fufang Luohanguo Qingfei granules reduces influenza virus susceptibility via MAVS-dependent type I interferon antiviral signaling","volume":"324","author":"Lu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41392-020-00238-z","article-title":"Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-\u03b2 responses by Mfn2-mediated ubiquitin degradation of MAVS","volume":"5","author":"Luo","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"B51","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00109-017-1541-5","article-title":"MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling","volume":"95","author":"Ma","year":"2017","journal-title":"J. Mol. Med. Berl."},{"key":"B52","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12931-023-02631-y","article-title":"Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension","volume":"24","author":"Ma","year":"2023","journal-title":"Respir. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2147\/IJN.S232986","article-title":"Silver nanoparticle exposure causes pulmonary structural damage and mitochondrial dynamic imbalance in the rat: protective effects of sodium selenite","volume":"15","author":"Ma","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"B54","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.tips.2023.09.002","article-title":"Unravelling the signaling power of pollutants","volume":"44","author":"Manzano-Covarrubias","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"115011","DOI":"10.1016\/j.bcp.2022.115011","article-title":"Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases","volume":"199","author":"Mao","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"114788","DOI":"10.1016\/j.taap.2019.114788","article-title":"Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice","volume":"385","author":"Maremanda","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"102055","DOI":"10.1016\/j.redox.2021.102055","article-title":"Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD","volume":"45","author":"Maremanda","year":"2021","journal-title":"Redox Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"eabo7728","DOI":"10.1126\/scitranslmed.abo7728","article-title":"Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration","volume":"15","author":"Mikami","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mito.2021.04.009","article-title":"The role of mitophagy in pulmonary sepsis","volume":"59","author":"Mohsin","year":"2021","journal-title":"Mitochondrion"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/toxsci\/kfad003","article-title":"Air pollution and respiratory infections: the past, present, and future","volume":"192","author":"Monoson","year":"2023","journal-title":"Toxicol. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/abbs\/gmaa161","article-title":"miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2","volume":"53","author":"Mu","year":"2021","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"704044","DOI":"10.3389\/fphys.2021.704044","article-title":"Sepsis disrupts mitochondrial function and diaphragm morphology","volume":"12","author":"Oliveira","year":"2021","journal-title":"Front. Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"103049","DOI":"10.1016\/j.redox.2024.103049","article-title":"Mitochondrial network dynamics in pulmonary disease: bridging the gap between inflammation, oxidative stress, and bioenergetics","volume":"70","author":"Pokharel","year":"2024","journal-title":"Redox Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"783891","DOI":"10.3389\/fphys.2021.783891","article-title":"Transient receptor potential cation channel subfamily V member 4 mediates pyroptosis in chronic obstructive pulmonary disease","volume":"12","author":"Rao","year":"2021","journal-title":"Front. Physiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"119876","DOI":"10.1016\/j.lfs.2021.119876","article-title":"Mitochondrial dynamics and mitophagy in lung disorders","volume":"284","author":"Sharma","year":"2021","journal-title":"Life Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1038\/s41374-019-0286-x","article-title":"PI3K\/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury","volume":"99","author":"Shi","year":"2019","journal-title":"Lab. Invest"},{"key":"B68","doi-asserted-by":"publisher","first-page":"4253","DOI":"10.3390\/jcm12134253","article-title":"Oxidative biomarkers associated with the pulmonary manifestation of post-COVID-19 complications","volume":"12","author":"Siekacz","year":"2023","journal-title":"J. Clin. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e1008085","DOI":"10.1371\/journal.pgen.1008085","article-title":"Mitochondrial fusion is required for regulation of mitochondrial DNA replication","volume":"15","author":"Silva Ramos","year":"2019","journal-title":"PLoS Genet."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e0175009","DOI":"10.1371\/journal.pone.0175009","article-title":"Resveratrol reduces the apoptosis induced by cigarette smoke extract by upregulating MFN2","volume":"12","author":"Song","year":"2017","journal-title":"PLoS One"},{"key":"B71","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/1354750X.2021.2023219","article-title":"Dexmedetomidine modulates mitochondrial dynamics to protect against endotoxin-induced lung injury via the protein kinase C-\u0251\/haem oxygenase-1 signalling pathway","volume":"27","author":"Song","year":"2022","journal-title":"Biomarkers"},{"key":"B72","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/SHK.0000000000002206","article-title":"Promoting mitochondrial dynamic equilibrium attenuates sepsis-induced acute lung injury by inhibiting proinflammatory polarization of alveolar macrophages","volume":"60","author":"Sun","year":"2023","journal-title":"Shock"},{"key":"B73","doi-asserted-by":"publisher","first-page":"7888937","DOI":"10.1155\/2022\/7888937","article-title":"Activation of PPAR\u03b3 protects obese mice from acute lung injury by inhibiting endoplasmic reticulum stress and promoting mitochondrial biogenesis","volume":"2022","author":"Tang","year":"2022","journal-title":"PPAR Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/IntJMedMushrooms.2022046311","article-title":"King oyster mushroom, Pleurotus eryngii (agaricomycetes), extract can attenuate doxorubicin-induced lung damage by inhibiting oxidative stress in rats","volume":"25","author":"Tektemur","year":"2023","journal-title":"Int. J. Med. Mushrooms"},{"key":"B75","doi-asserted-by":"publisher","first-page":"10697","DOI":"10.3390\/ijms231810697","article-title":"Activation of inflammatory networks in the lungs caused by chronic cold stress is moderately attenuated by glucose supplementation","volume":"23","author":"Teng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3390\/cells12020299","article-title":"Disruption of the molecular regulation of mitochondrial metabolism in airway and lung epithelial cells by cigarette smoke: are aldehydes the culprit?","volume":"12","author":"Tulen","year":"2023","journal-title":"Cells"},{"key":"B77","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.freeradbiomed.2019.01.004","article-title":"Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model","volume":"134","author":"Wang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1165\/rcmb.2020-0008OC","article-title":"Mitochondrial fission mediated cigarette smoke-induced pulmonary endothelial injury","volume":"63","author":"Wang","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.2147\/DMSO.S278684","article-title":"Adiponectin protects obese rats from aggravated acute lung injury via suppression of endoplasmic reticulum stress","volume":"13","author":"Wei","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"B80","doi-asserted-by":"publisher","first-page":"170668","DOI":"10.1016\/j.scitotenv.2024.170668","article-title":"TRPA1-PI3K\/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury","volume":"918","author":"Weng","year":"2024","journal-title":"Sci. Total Environ."},{"key":"B81","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.ccc.2021.05.002","article-title":"Environmental factors","volume":"37","author":"Wick","year":"2021","journal-title":"Crit. Care Clin."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e101056","DOI":"10.15252\/embj.2018101056","article-title":"Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent","volume":"38","author":"Wolf","year":"2019","journal-title":"EMBO J."},{"key":"B83","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1111\/febs.16793","article-title":"Rab26 promotes macrophage phagocytosis through regulation of MFN2 trafficking to mitochondria","volume":"290","author":"Wu","year":"2023","journal-title":"FEBS J."},{"key":"B84","doi-asserted-by":"publisher","first-page":"647631","DOI":"10.3389\/fcell.2021.647631","article-title":"Mitofusin-2: a new mediator of pathological cell proliferation","volume":"9","author":"Xin","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1080\/10715762.2019.1630735","article-title":"Mitochondrial ROS and NLRP3 inflammasome in acute ozone-induced murine model of airway inflammation and bronchial hyperresponsiveness","volume":"53","author":"Xu","year":"","journal-title":"Free Radic. Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1002\/tox.23140","article-title":"Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM2.5 in mice","volume":"36","author":"Xu","year":"2021","journal-title":"Environ. Toxicol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"7450151","DOI":"10.1155\/2019\/7450151","article-title":"TRPV1 and TRPA1 in lung inflammation and airway hyperresponsiveness induced by fine particulate matter (PM2.5)","volume":"2019","author":"Xu","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B88","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/s12890-023-02626-x","article-title":"Hyperoxia but not high tidal volume contributes to ventilator-induced lung injury in healthy mice","volume":"23","author":"Xu","year":"2023","journal-title":"BMC Pulm. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"107149","DOI":"10.1016\/j.intimp.2020.107149","article-title":"Mitoquinone ameliorates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice","volume":"90","author":"Yang","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"6644238","DOI":"10.1155\/2021\/6644238","article-title":"Mitochondrial-targeting antioxidant SS-31 suppresses airway inflammation and oxidative stress induced by cigarette smoke","volume":"2021","author":"Yang","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B91","doi-asserted-by":"publisher","first-page":"L483","DOI":"10.1152\/ajplung.00212.2019","article-title":"TNF\u03b1 selectively activates the IRE1\u03b1\/XBP1 endoplasmic reticulum stress pathway in human airway smooth muscle cells","volume":"318","author":"Yap","year":"2020","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1002\/1873-3468.14077","article-title":"Mitochondrial dynamics in health and disease","volume":"595","author":"Yapa","year":"2021","journal-title":"FEBS Lett."},{"key":"B93","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12951-024-02473-w","article-title":"Modulation of alveolar macrophage and mitochondrial fitness by medicinal plant-derived nanovesicles to mitigate acute lung injury and viral pneumonia","volume":"22","author":"Ye","year":"2024","journal-title":"J. Nanobiotechnology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/jcp.20753","article-title":"Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1","volume":"209","author":"Yoon","year":"2006","journal-title":"J. Cell Physiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1097\/ALN.0000000000001333","article-title":"Heme oxygenase-1\/carbon monoxide-regulated mitochondrial dynamic equilibrium contributes to the attenuation of endotoxin-induced acute lung injury in rats and in lipopolysaccharide-activated macrophages","volume":"125","author":"Yu","year":"","journal-title":"Anesthesiology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"36530","DOI":"10.1038\/srep36530","article-title":"Effect of heme oxygenase-1 on mitofusin-1 protein in LPS-induced ALI\/ARDS in rats","volume":"6","author":"Yu","year":"","journal-title":"Sci. Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"109973","DOI":"10.1016\/j.vetmic.2023.109973","article-title":"NDV inhibited IFN-\u03b2 secretion through impeding CHCHD10-mediated mitochondrial fusion to promote viral proliferation","volume":"290","author":"Yu","year":"2024","journal-title":"Vet. Microbiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1111\/bph.13518","article-title":"Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases","volume":"173","author":"Yue","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.tips.2022.11.004","article-title":"Mitochondrial dynamics proteins as emerging drug targets","volume":"44","author":"Zacharioudakis","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.molcel.2022.02.003","article-title":"MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex","volume":"82","author":"Zervopoulos","year":"2022","journal-title":"Mol. Cell"},{"key":"B101","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3892\/etm.2022.11406","article-title":"Mitochondria and their potential role in acute lung injury (Review)","volume":"24","author":"Zhan","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41416-019-0658-4","article-title":"MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming","volume":"122","author":"Zhang","year":"2020","journal-title":"Br. J. Cancer"},{"key":"B103","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.toxlet.2019.04.029","article-title":"Effects of abnormal expression of fusion and fission genes on the morphology and function of lung macrophage mitochondria in SiO2-induced silicosis fibrosis in rats in vivo","volume":"312","author":"Zhang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"B104","doi-asserted-by":"publisher","first-page":"6675264","DOI":"10.1155\/2021\/6675264","article-title":"Oxyberberine prevented lipopolysaccharide-induced acute lung injury through inhibition of mitophagy","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B105","doi-asserted-by":"publisher","first-page":"6638244","DOI":"10.1155\/2022\/6638244","article-title":"NR4A1 promotes LPS-induced acute lung injury through inhibition of opa1-mediated mitochondrial fusion and activation of PGAM5-related necroptosis","volume":"2022","author":"Zhu","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B106","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.semcdb.2010.01.002","article-title":"Mitochondrial fusion proteins: dual regulators of morphology and metabolism","volume":"21","author":"Zorzano","year":"2010","journal-title":"Semin. Cell Dev. Biol."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2025.1500247\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:13:45Z","timestamp":1742368425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2025.1500247\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":106,"alternative-id":["10.3389\/fphys.2025.1500247"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2025.1500247","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"article-number":"1500247"}}