{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:29:34Z","timestamp":1791973774373,"version":"4.4.0"},"reference-count":243,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>The majority of \u201cspecialised\u201d exercise configurations (e.g., supersets, drop sets, blood flow restriction) are being assessed as \u201cshortcuts\u201d to hypertrophy and strength improvements. However, these advanced training techniques may also offer significant benefits for systemic health and functional outcomes across recreational and clinical populations via locally induced metabolic responses. Stress-regulating mechanisms are known to enhance the body\u2019s resilience by facilitating allostasis, the process of coordinating adaptive processes in reaction to stressors such as physical training. Yet, the role of the local metabolic stress provoked by resistance exercise has not gained much research attention despite its wide potential. Positive effects are not only linked to improved muscular endurance, hypertrophy and strength via primary and secondary mechanisms, but also to the release of myokines, hormones, microRNAs, immune factors, inflammatory substances and other endocrine molecules that initiate numerous health-promoting modifications on a systemic level. Resistance exercise strategies that maximise the local accumulation of metabolites are not well defined, although high volume, close proximity to failure and shorter rests seem to be a necessity. Additionally, blood flow restriction training provides a potent alternative for inducing local acidosis, thereby triggering several pathways associated with improved immunity and physical function even in remote muscle tissues. Future research is warranted to further explore advanced resistance training techniques, as these approaches may offer comparable benefits for physical and mental health to those seen with other forms of exercise such as high-intensity interval training and heavy resistance training.<\/jats:p>","DOI":"10.3389\/fphys.2025.1549609","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:12:01Z","timestamp":1744888321000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?"],"prefix":"10.3389","volume":"16","author":[{"given":"Ivan","family":"Curovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1152\/japplphysiol.00283.2002","article-title":"Increased rate of force development and neural drive of human skeletal muscle following resistance training","volume":"93","author":"Aagaard","year":"2002","journal-title":"J. Appl. Physiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1519\/JSC.0000000000001479","article-title":"Effects of a strength training session after an exercise inducing muscle damage on recovery Kinetics","volume":"31","author":"Aba\u00efdia","year":"2017","journal-title":"J. Strength Cond. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e13007","DOI":"10.1111\/obr.13007","article-title":"Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: a systematic review and meta-analysis","volume":"21","author":"Acosta-Manzano","year":"2020","journal-title":"Obes. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.autrev.2017.12.005","article-title":"Skeletal muscle cells actively shape (auto)immune responses","volume":"17","author":"Afzali","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1038\/s41467-019-10712-0","article-title":"Skeletal muscle PGC-1\u03b11 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance","volume":"10","author":"Agudelo","year":"2019","journal-title":"Nat. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s00421-015-3150-8","article-title":"A single set of exhaustive exercise before resistance training improves muscular performance in young men","volume":"115","author":"Aguiar","year":"2015","journal-title":"Eur. J. Appl. Physiol."},{"key":"B7","volume-title":"ACSM\u2019s guidelines for exercise testing and Prescription","year":"2021"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1249\/MSS.0000000000001984","article-title":"Blood flow\u2013restricted exercise does not induce a cross-transfer of effect: a randomized controlled trial","volume":"51","author":"Ampomah","year":"2019","journal-title":"Med. and Sci. Sports and Exerc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/cercor\/bhz075","article-title":"Intensity Matters: high-intensity interval exercise enhances motor Cortex plasticity more than moderate exercise","volume":"30","author":"Andrews","year":"2020","journal-title":"Cereb. Cortex"},{"key":"B10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.22540\/JFSF-08-107","article-title":"The effectiveness of blood flow restriction training in cardiovascular disease patients: a scoping review","volume":"8","author":"Angelopoulos","year":"2023","journal-title":"J. Frailty Sarcopenia Falls"},{"key":"B11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2165\/00007256-199112030-00004","article-title":"Mechanisms of exercise-induced muscle fibre injury","volume":"12","author":"Armstrong","year":"2012","journal-title":"Sports Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7201","DOI":"10.3390\/ijerph18137201","article-title":"Evidence-based effects of high-intensity interval training on exercise capacity and health: a review with Historical perspective","volume":"18","author":"Atakan","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1007\/s00421-019-04180-z","article-title":"Effects of upper-body, lower-body, or combined resistance training on the ratio of follistatin and myostatin in middle-aged men","volume":"119","author":"Bagheri","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-3-030-48457-6_2","article-title":"Decorin in the tumor Microenvironment","volume":"1272","author":"Baghy","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1519\/JSC.0000000000001639","article-title":"Effect of lower-body resistance training on upper-body strength adaptation in trained men","volume":"32","author":"Bartolomei","year":"2018","journal-title":"J. Strength Cond. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2165\/00007256-199825040-00004","article-title":"Age-related alterations in muscular endurance","volume":"25","author":"Bemben","year":"1998","journal-title":"Sports Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/00005768-199601000-00026","article-title":"Isometric intermittent endurance of four muscle groups in men aged 20-74 yr","volume":"28","author":"Bemben","year":"1996","journal-title":"Med. Sci. Sports Exerc"},{"key":"B18","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.jshs.2024.04.005","article-title":"Exercise training mode effects on myokine expression in healthy adults: a systematic review with meta-analysis","volume":"13","author":"Bettariga","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.0642","article-title":"Long-term improvement in hippocampal-dependent Learning ability in healthy, aged individuals following high intensity interval training","author":"Blackmore","year":"2024","journal-title":"Aging Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e14528","DOI":"10.1111\/sms.14528","article-title":"Decreased neural drive affects the early rate of force development after repeated burst-like isometric contractions","volume":"34","author":"Boccia","year":"2024","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B21","doi-asserted-by":"publisher","first-page":"520258","DOI":"10.1155\/2010\/520258","article-title":"The role of exercise-induced myokines in muscle Homeostasis and the defense against chronic diseases","volume":"2010","author":"Brandt","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1113\/JP280955","article-title":"Lactate in contemporary biology: a phoenix risen","volume":"600","author":"Brooks","year":"","journal-title":"J. physiology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s12276-022-00802-3","article-title":"Tracing the lactate shuttle to the mitochondrial reticulum","volume":"54","author":"Brooks","year":"","journal-title":"Exp. and Mol. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1152\/japplphysiol.00497.2022","article-title":"Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism","volume":"134","author":"Brooks","year":"2023","journal-title":"J. Appl. Physiology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2403712","DOI":"10.1002\/adhm.202403712","article-title":"Actuating Extracellular Matrices Decouple the mechanical and biochemical effects of muscle contraction on motor neurons","volume":"14","author":"Bu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.3390\/antiox13111363","article-title":"Myokines and their potential protective role against oxidative stress in metabolic Dysfunction-associated Steatotic liver disease (MASLD)","volume":"13","author":"Bucarey","year":"2024","journal-title":"Antioxidants"},{"key":"B27","doi-asserted-by":"publisher","first-page":"102181","DOI":"10.1016\/j.arr.2023.102181","article-title":"Hormesis determines lifespan","volume":"94","author":"Calabrese","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"14522","DOI":"10.18632\/aging.203051","article-title":"Effects of exercise on cellular and tissue aging","volume":"13","author":"Carapeto","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1080\/10715762.2018.1440293","article-title":"Acute effects of blood flow restriction on exercise-induced free radical production in young and healthy subjects","volume":"52","author":"Centner","year":"2018","journal-title":"Free Radic. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e13800","DOI":"10.14814\/phy2.13800","article-title":"Lactate administration activates the ERK1\/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse","volume":"6","author":"Cerda\u2010Kohler","year":"2018","journal-title":"Physiol. Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease","volume":"18","author":"Chow","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"737","DOI":"10.2165\/00007256-200737090-00001","article-title":"The molecular bases of training adaptation","volume":"37","author":"Coffey","year":"2007","journal-title":"Sports Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/s1388-2457(99)00054-1","article-title":"The relationship of motor unit size, firing rate and force","volume":"110","author":"Conwit","year":"1999","journal-title":"Clin. Neurophysiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1123\/ijspp.2013-0018","article-title":"Improving strength and power in trained athletes with 3 weeks of occlusion training","volume":"9","author":"Cook","year":"2014","journal-title":"Int. J. sports physiology Perform."},{"key":"B35","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1249\/MSS.0b013e31826c6fa8","article-title":"Neuromuscular function after a bout of low-load blood flow-restricted exercise","volume":"45","author":"Cook","year":"2013","journal-title":"Med. Sci. Sports Exerc"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1007\/s40279-024-02039-8","article-title":"Vertical strength transfer phenomenon between upper body and lower body exercise: systematic scoping review","volume":"54","author":"Curovic","year":"2024","journal-title":"Sports Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s40279-016-0633-7","article-title":"Training to fatigue: the Answer for Standardization when assessing muscle hypertrophy?","volume":"47","author":"Dankel","year":"2017","journal-title":"Sports Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5662\/wjm.v7.i2.46","article-title":"Role of metabolic stress for enhancing muscle adaptations: practical applications","volume":"7","author":"de Freitas","year":"2017","journal-title":"World J. Methodol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s11332-019-00536-2","article-title":"Effects of low-load resistance training with blood flow restriction on the perceived exertion, muscular resistance and endurance in healthy young adults","volume":"15","author":"de Lemos Muller","year":"2019","journal-title":"Sport Sci. Health"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e13207","DOI":"10.1111\/psyg.13207","article-title":"Different physical exercise in the treatment of Alzheimer\u2019s disease","volume":"25","author":"Deng","year":"2024","journal-title":"Psychogeriatrics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fphys.2019.00352","article-title":"Creatine Supplementation improves phosphagen energy pathway during Supramaximal effort, but does not improve anaerobic capacity or performance","volume":"10","author":"de Poli","year":"2019","journal-title":"Front. Physiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/00002060-200211001-00003","article-title":"Performance and physiologic adaptations to resistance training","volume":"81","author":"Deschenes","year":"2002","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"B43","volume-title":"The effects of isometric exercise training on resting blood pressure with specific reference to selected cardiovascular, neuromuscular, and metabolic variables","author":"Devereux","year":"2010"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1080\/02640414.2012.692482","article-title":"Lactate accumulation following isometric exercise training and its relationship with reduced resting blood pressure","volume":"30","author":"Devereux","year":"2012","journal-title":"J. Sports Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13102-022-00397-2","article-title":"The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review","volume":"14","author":"Docherty","year":"2022","journal-title":"BMC Sports Sci. Med. Rehabilitation"},{"key":"B46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1055\/a-0824-4813","article-title":"MicroRNA profile and adaptive response to exercise training: a review","volume":"40","author":"Doma\u0144ska-Senderowska","year":"2019","journal-title":"Int. J. sports Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e12750","DOI":"10.1111\/acel.12750","article-title":"Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood","volume":"17","author":"Duggal","year":"2018","journal-title":"Aging Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1136\/bjsports-2022-106503","article-title":"Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials","volume":"57","author":"Edwards","year":"2023","journal-title":"Br. J. Sports Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1097\/HJH.0000000000003261","article-title":"Mechanisms for blood pressure reduction following isometric exercise training: a systematic review and meta-analysis","volume":"40","author":"Edwards","year":"2022","journal-title":"J. Hypertens."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1519\/JSC.0000000000001981","article-title":"Aerobic exercise supplemented with muscular endurance training improves onset of blood lactate accumulation","volume":"32","author":"Farrell","year":"2018","journal-title":"J. Strength and Cond. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/sms.12396","article-title":"Blood flow restricted and traditional resistance training performed to fatigue produce equal muscle hypertrophy","volume":"25","author":"Farup","year":"2015","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1392483","DOI":"10.3389\/fphys.2024.1392483","article-title":"Effect of blood flow restriction training on health promotion in middle-aged and elderly women: a systematic review and meta-analysis","volume":"15","author":"Feng","year":"2024","journal-title":"Front. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1089\/ars.2013.5773","article-title":"Exercise-induced skeletal muscle remodeling and metabolic adaptation: Redox signaling and role of Autophagy","volume":"21","author":"Ferraro","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"B54","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/cpf.12409","article-title":"Effects of rest intervals and training loads on metabolic stress and muscle hypertrophy","volume":"38","author":"Fink","year":"2018","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"B55","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s42978-020-00092-z","article-title":"Physiological responses to agonist\u2013antagonist superset resistance training","volume":"3","author":"Fink","year":"2021","journal-title":"J SCI SPORT Exerc."},{"key":"B56","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1055\/s-0042-119204","article-title":"Acute and long-term responses to different rest intervals in low-load resistance training","volume":"38","author":"Fink","year":"2017","journal-title":"Int. J. Sports Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1113\/JP275972","article-title":"Metabolic stress-dependent regulation of the mitochondrial biogenic molecular response to high-intensity exercise in human skeletal muscle","volume":"596","author":"Fiorenza","year":"2018","journal-title":"J. Physiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/mus.25537","article-title":"Heavier and lighter load resistance training to momentary failure produce similar increases in strength with differing degrees of discomfort","volume":"56","author":"Fisher","year":"2017","journal-title":"Muscle Nerve"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17338\/trainology.9.1_1","article-title":"The strength-endurance continuum revisited:a critical commentary of the recommendation ofdifferent loading ranges for different muscular adaptations","volume":"9","author":"Fisher J","year":"2020","journal-title":"J. Trainology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e705","DOI":"10.1161\/CIR.0000000000000749","article-title":"Exercise-related acute cardiovascular events and potential Deleterious adaptations following long-term exercise training: Placing the risks into perspective\u2013an update: a Scientific Statement from the American heart association","volume":"141","author":"Franklin","year":"2020","journal-title":"Circulation"},{"key":"B61","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1152\/japplphysiol.00195.2007","article-title":"Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis","volume":"103","author":"Fujita","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1016\/j.apmr.2018.01.008","article-title":"Muscular strength as a predictor of all-cause mortality in an Apparently healthy population: a systematic review and meta-analysis of Data from Approximately 2 Million men and women","volume":"99","author":"Garc\u00eda-Hermoso","year":"2018","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"B63","doi-asserted-by":"publisher","first-page":"725","DOI":"10.2165\/00007256-200131100-00003","article-title":"Energy system interaction and relative contribution during maximal exercise","volume":"31","author":"Gastin","year":"2001","journal-title":"Sports Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/bjsm.2007.041970","article-title":"The role of lactate in the exercise-induced human growth hormone response: evidence from McArdle disease","volume":"43","author":"Godfrey","year":"2009","journal-title":"Br. J. Sports Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s00421-008-0836-1","article-title":"Resistance exercise effects on blood glutathione status and plasma protein carbonyls: influence of partial vascular occlusion","volume":"104","author":"Goldfarb","year":"2008","journal-title":"Eur. J. Appl. Physiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/bs.acc.2019.07.010","article-title":"Myokines: the endocrine coupling of skeletal muscle and bone","volume":"94","author":"Gomarasca","year":"2020","journal-title":"Adv. Clin. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1249\/01.mss.0000170470.98084.39","article-title":"The impact of metabolic stress on hormonal responses and muscular adaptations","volume":"37","author":"Goto","year":"2005","journal-title":"Med. Sci. Sports Exerc"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.70252\/ODIN6912","article-title":"EPOC Comparison between resistance training and high-intensity interval training in Aerobically Fit women","volume":"14","author":"Greer","year":"2021","journal-title":"Int. J. Exerc Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jshs.2021.01.007","article-title":"Effects of resistance training performed to repetition failure or non-failure on muscular strength and hypertrophy: a systematic review and meta-analysis","volume":"11","author":"Grgic","year":"2022","journal-title":"J. Sport Health Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s40279-017-0788-x","article-title":"Effects of rest interval duration in resistance training on measures of muscular strength: a systematic review","volume":"48","author":"Grgic","year":"2018","journal-title":"Sports Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/sms.13632","article-title":"Effect of blood-flow restricted vs heavy-load strength training on muscle strength: systematic review and meta-analysis","volume":"30","author":"Gr\u00f8nfeldt","year":"2020","journal-title":"Scand. J. Med. and Sci. Sports"},{"key":"B72","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.tem.2023.07.006","article-title":"Cytokines and exosomal miRNAs in skeletal Muscle\u2013adipose crosstalk","volume":"34","author":"Guo","year":"2023","journal-title":"Trends Endocrinol. and Metabolism"},{"key":"B73","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.scispo.2021.11.002","article-title":"Influence of total repetitions per set on local muscular endurance: a systematic review with meta-analysis and meta-regression","volume":"37","author":"Hackett","year":"2022","journal-title":"Sci. and Sports"},{"key":"B74","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1034\/j.1600-0838.2001.110606.x","article-title":"The effect of short-term strength training on human skeletal muscle: the importance of physiologically elevated hormone levels","volume":"11","author":"Hansen","year":"2001","journal-title":"Scand. J. Med. and Sci. sports"},{"key":"B75","doi-asserted-by":"publisher","first-page":"R83-R92","DOI":"10.1152\/ajpregu.00022.2019","article-title":"Skeletal muscle signaling responses to resistance exercise of the elbow extensors are not compromised by a preceding bout of aerobic exercise","volume":"317","author":"Hansson","year":"2019","journal-title":"Am. J. physiology Regul. Integr. Comp. physiology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s42255-020-0251-4","article-title":"Skeletal muscle energy metabolism during exercise","volume":"2","author":"Hargreaves","year":"2020","journal-title":"Nat. Metab."},{"key":"B77","doi-asserted-by":"publisher","first-page":"C807","DOI":"10.1152\/ajpcell.00094.2009","article-title":"IL-7 is expressed and secreted by human skeletal muscle cells","volume":"298","author":"Haugen","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13102-023-00713-4","article-title":"Effect of free-weight vs. machine-based strength training on maximal strength, hypertrophy and jump performance \u2013 a systematic review and meta-analysis","volume":"15","author":"Haugen","year":"2023","journal-title":"BMC Sports Sci. Med. Rehabil."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s40279-021-01481-2","article-title":"Crossing the Golden training Divide: the Science and practice of training World-Class 800- and 1500-m Runners","volume":"51","author":"Haugen","year":"2021","journal-title":"Sports Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.asmr.2021.09.024","article-title":"Blood flow restriction enhances rehabilitation and Return to Sport: the paradox of proximal performance","volume":"4","author":"Hedt","year":"2022","journal-title":"Arthrosc. Sports Med. Rehabil."},{"key":"B81","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40798-021-00404-9","article-title":"The effect of load and volume Autoregulation on muscular strength and hypertrophy: a systematic review and meta-analysis","volume":"8","author":"Hickmott","year":"2022","journal-title":"Sports Med. - Open"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e14030","DOI":"10.1111\/apha.14030","article-title":"Hormonal, immune, and oxidative stress responses to blood flow-restricted exercise","volume":"239","author":"Hjortshoej","year":"2023","journal-title":"Acta Physiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"18383","DOI":"10.1038\/s41598-024-68187-z","article-title":"Cardiorespiratory and aerobic demands of squat exercise","volume":"14","author":"Hong","year":"2024","journal-title":"Sci. Rep."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e2313590121","DOI":"10.1073\/pnas.2313590121","article-title":"Neuronal innervation regulates the secretion of neurotrophic myokines and exosomes from skeletal muscle","volume":"121","author":"Huang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B85","doi-asserted-by":"publisher","first-page":"656455","DOI":"10.3389\/fphys.2021.656455","article-title":"Lactate as potential mediators for exercise-induced positive effects on neuroplasticity and cerebrovascular plasticity","volume":"12","author":"Huang","year":"2021","journal-title":"Front. physiology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"a029769","DOI":"10.1101\/cshperspect.a029769","article-title":"Adaptations to endurance and strength training","volume":"8","author":"Hughes","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1152\/japplphysiol.00768.2019","article-title":"The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation","volume":"128","author":"Hughes","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12272-017-0994-y","article-title":"The role of exercise-induced myokines in regulating metabolism","volume":"41","author":"Huh","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"B89","first-page":"361","article-title":"Skeletal muscle energy metabolism and fatigue during intense exercise in man","volume":"75","author":"Hultman","year":"1991","journal-title":"Sci. Prog."},{"key":"B90","doi-asserted-by":"publisher","first-page":"S167-S179","DOI":"10.1519\/JSC.0000000000002384","article-title":"Mechanisms behind blood flow-restricted training and its effect toward muscle growth","volume":"33","author":"Hwang","year":"2019","journal-title":"J. strength Cond. Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/hr.2015.111","article-title":"Isometric exercise training for blood pressure management: a systematic review and meta-analysis to optimize benefit","volume":"39","author":"Inder","year":"2016","journal-title":"Hypertens. Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1038\/s42255-021-00438-z","article-title":"Exercise hormone irisin is a critical regulator of cognitive function","volume":"3","author":"Islam","year":"2021","journal-title":"Nat. Metab."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s40279-021-01490-1","article-title":"No time to Lift? Designing time-efficient training Programs for strength and hypertrophy: a narrative review","volume":"51","author":"Iversen","year":"2021","journal-title":"Sports Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/19417381221101006","article-title":"Blood flow restriction therapy preserves lower extremity bone and muscle mass after ACL Reconstruction","volume":"15","author":"Jack","year":"2023","journal-title":"Sports Health"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.70252\/DYRH9028","article-title":"Effects of different types of lower body resistance exercise on upper-body strength in men and women, with special reference to anabolic hormones","volume":"14","author":"Jakobsson","year":"2021","journal-title":"Int. J. Exerc. Sci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"160","DOI":"10.55860\/swdb1533","article-title":"Resistance training status detection via local muscular endurance adaptation maximum repetition strategy: Brief review","volume":"3","author":"Kahraman","year":"2024","journal-title":"Sci. J. Sport Perform."},{"key":"B97","doi-asserted-by":"publisher","first-page":"S136","DOI":"10.1519\/JSC.0000000000003163","article-title":"Impact of two high-volume set configuration Workouts on resistance training outcomes in recreationally trained men","volume":"35","author":"Karsten","year":"2021","journal-title":"J. Strength Cond. Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1519\/JSC.0b013e3181d3e993","article-title":"The metabolic costs of reciprocal supersets vs. traditional resistance exercise in young recreationally active adults","volume":"24","author":"Kelleher","year":"2010","journal-title":"J. Strength Cond. Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1096\/fj.01-0507fje","article-title":"Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content","volume":"15","author":"Keller","year":"2001","journal-title":"FASEB J."},{"key":"B100","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s11332-024-01281-x","article-title":"Equated volume load: similar improvements in muscle strength, endurance, and hypertrophy for traditional, pre-exhaustion, and drop sets in resistance training","volume":"21","author":"Keskin","year":"2025","journal-title":"Sport Sci. Health"},{"key":"B101","doi-asserted-by":"publisher","first-page":"114272","DOI":"10.1016\/j.physbeh.2023.114272","article-title":"The effects of resistance training on myostatin and follistatin in adults: a systematic review and meta-analysis","volume":"269","author":"Khalafi","year":"2023","journal-title":"Physiol. Behav."},{"key":"B102","doi-asserted-by":"publisher","first-page":"271","DOI":"10.33549\/physiolres.932997","article-title":"Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight\/obese adults: a pilot study","volume":"65","author":"Kim","year":"2016","journal-title":"Physiol. Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s42255-022-00538-4","article-title":"Interleukin 6 as an energy allocator in muscle tissue","volume":"4","author":"Kistner","year":"2022","journal-title":"Nat. Metab."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1038\/s41467-022-30056-6","article-title":"Enhancement of anaerobic glycolysis - a role of PGC-1\u03b14 in resistance exercise","volume":"13","author":"Koh","year":"2022","journal-title":"Nat. Commun."},{"key":"B105","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00421-005-0118-0","article-title":"Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males","volume":"96","author":"Koopman","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ptsp.2018.05.021","article-title":"Blood Flow Restriction induces hypoalgesia in recreationally active adult male anterior knee pain patients allowing therapeutic exercise loading","volume":"32","author":"Korakakis","year":"2018","journal-title":"Phys. Ther. Sport"},{"key":"B107","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1139\/apnm-2015-0464","article-title":"Effects of partial vascular occlusion on irisin responses to loaded muscle contractions","volume":"41","author":"Kraemer","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"B108","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1152\/jappl.1995.78.3.976","article-title":"Compatibility of high-intensity strength and endurance training on hormonal and skeletal muscle adaptations","volume":"78","author":"Kraemer","year":"1995","journal-title":"J. Appl. Physiology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2165\/00007256-200535040-00004","article-title":"Hormonal responses and adaptations to resistance exercise and training","volume":"35","author":"Kraemer","year":"2005","journal-title":"Sports Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ypmed.2016.02.038","article-title":"Is strength training associated with mortality benefits? A 15year cohort study of US older adults","volume":"87","author":"Kraschnewski","year":"2016","journal-title":"Prev. Med."},{"key":"B111","first-page":"27","article-title":"ATP supply and demand during exercise","volume-title":"Exercise, nutrition, energy and metabolism","author":"Krisanda","year":"1988"},{"key":"B112","doi-asserted-by":"publisher","first-page":"4897","DOI":"10.3390\/ijerph16244897","article-title":"Maximizing muscle hypertrophy: a systematic review of advanced resistance training techniques and methods","volume":"16","author":"Krzysztofik","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B113","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s11357-024-01295-w","article-title":"The untapped potential of cold water therapy as part of a lifestyle intervention for promoting healthy aging","volume":"47","author":"Kunutsor","year":"2024","journal-title":"GeroScience"},{"key":"B114","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/cpf.12147","article-title":"Effects of resistance training under hypoxic conditions on muscle hypertrophy and strength","volume":"35","author":"Kurobe","year":"2015","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"B115","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/healthcare8040378","article-title":"Exercise-induced myokines can explain the importance of physical activity in the elderly: an overview","volume":"8","author":"Kwon","year":"2020","journal-title":"Healthc. (Basel)"},{"key":"B116","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1519\/JSC.0000000000001044","article-title":"Variations in repetition duration and repetition numbers influence muscular activation and blood lactate response in protocols Equalized by time under tension","volume":"30","author":"Lacerda","year":"2016","journal-title":"J. Strength Cond. Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"11237","DOI":"10.3390\/ijerph182111237","article-title":"Effects of resistance training performed with different loads in untrained and trained male adult individuals on maximal strength and muscle hypertrophy: a systematic review","volume":"18","author":"Lacio","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1249\/MSS.0b013e3182625928","article-title":"Blood flow restriction enhances post-resistance exercise angiogenic gene expression","volume":"44","author":"Larkin","year":"2012","journal-title":"Med. Sci. Sports Exerc"},{"key":"B119","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1519\/JSC.0000000000003454","article-title":"Muscle failure promotes greater muscle hypertrophy in low-load but not in high-load resistance training","volume":"36","author":"Lasevicius","year":"2022","journal-title":"J. Strength Cond. Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1080\/17461391.2018.1450898","article-title":"Effects of different intensities of resistance training with equated volume load on muscle strength and hypertrophy","volume":"18","author":"Lasevicius","year":"2018","journal-title":"Eur. J. Sport Sci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fphys.2020.00091","article-title":"Exercise-released myokines in the control of energy metabolism","volume":"11","author":"Laurens","year":"2020","journal-title":"Front. Physiol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1249\/MSS.0b013e318233b4bc","article-title":"Strength training with blood flow restriction diminishes myostatin gene expression","volume":"44","author":"Laurentino","year":"2012","journal-title":"Med. Sci. Sports Exerc"},{"key":"B123","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/jfmk7040081","article-title":"Beyond mechanical tension: a review of resistance exercise-induced lactate responses and muscle hypertrophy","volume":"7","author":"Lawson","year":"2022","journal-title":"J. Funct. Morphol. Kinesiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3389\/fphys.2018.01307","article-title":"Physical exercise-induced myokines and muscle-adipose tissue crosstalk: a review of current knowledge and the implications for health and metabolic diseases","volume":"9","author":"Leal","year":"2018","journal-title":"Front. Physiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fphys.2019.00042","article-title":"Role of myokines in regulating skeletal muscle mass and function","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Physiol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1177\/1941738120944256","article-title":"Muscle atrophy after ACL injury: implications for clinical practice","volume":"12","author":"Lepley","year":"2020","journal-title":"Sports Health"},{"key":"B127","doi-asserted-by":"publisher","first-page":"620","DOI":"10.70252\/HSVD9987","article-title":"Older adult aerobic capacity, muscular strength, fitness and body composition after 20+ Years of exercise training: a systematic review and meta-analysis","volume":"16","author":"Leslie","year":"2023","journal-title":"Int. J. Exerc Sci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1249\/MSS.0000000000001448","article-title":"Associations of muscle mass and strength with all-cause mortality among US older adults","volume":"50","author":"Li","year":"2018","journal-title":"Med. Sci. Sports Exerc"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1289574","DOI":"10.3389\/fendo.2023.1289574","article-title":"The effect of blood flow restriction exercise on N-lactoylphenylalanine and appetite regulation in obese adults: a cross-design study","volume":"14","author":"Li","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1249\/MSS.0000000000002088","article-title":"Resistance exercise-induced changes in muscle phenotype are load dependent","volume":"51","author":"Lim","year":"2019","journal-title":"Med. Sci. Sports Exerc"},{"key":"B131","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1519\/R-15404.1","article-title":"Acute hormonal responses to submaximal and maximal heavy resistance and Explosive exercises in men and women","volume":"19","author":"Linnamo","year":"2005","journal-title":"J. Strength Cond. Res."},{"key":"B132","doi-asserted-by":"publisher","first-page":"668759","DOI":"10.3389\/fcell.2021.668759","article-title":"The role of irisin in exercise-mediated bone health","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1496482","DOI":"10.3389\/fpubh.2024.1496482","article-title":"The effect of blood flow restriction training on core muscle strength and pain in male collegiate athletes with chronic non-specific low back pain","volume":"12","author":"Liu","year":"2024","journal-title":"Front. Public Health"},{"key":"B134","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s40279-017-0795-y","article-title":"Magnitude of muscle strength and mass adaptations between high-load resistance training versus low-load resistance training associated with blood-flow restriction: a systematic review and meta-analysis","volume":"48","author":"Lixandr\u00e3o","year":"2018","journal-title":"Sports Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.mehy.2011.07.029","article-title":"Blood flow restriction: the metabolite\/volume threshold theory","volume":"77","author":"Loenneke","year":"2011","journal-title":"Med. Hypotheses"},{"key":"B136","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1152\/japplphysiol.01082.2013","article-title":"Exercise-induced AMPK activation does not interfere with muscle hypertrophy in response to resistance training in men","volume":"116","author":"Lundberg","year":"2014","journal-title":"J. Appl. physiology Bethesda"},{"key":"B137","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1249\/mss.0b013e31815c6d7e","article-title":"Cross-transfer effects of resistance training with blood flow restriction","volume":"40","author":"Madarame","year":"2008","journal-title":"Med. Sci. sports Exerc."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s00421-016-3346-6","article-title":"Rate of force development: physiological and methodological considerations","volume":"116","author":"Maffiuletti","year":"2016","journal-title":"Eur. J. Appl. Physiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jsams.2012.08.009","article-title":"Effects of low-load resistance training combined with blood flow restriction or hypoxia on muscle function and performance in netball athletes","volume":"16","author":"Manimmanakorn","year":"2013","journal-title":"J. Sci. Med. Sport"},{"key":"B140","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ghir.2012.05.002","article-title":"Growth hormone responses to acute resistance exercise with vascular restriction in young and old men","volume":"22","author":"Manini","year":"2012","journal-title":"Growth Horm. IGF Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s00421-019-04202-w","article-title":"Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized-controlled trial","volume":"119","author":"Marston","year":"2019","journal-title":"Eur. J. Appl. Physiol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.jsams.2017.03.015","article-title":"Intense resistance exercise increases peripheral brain-derived neurotrophic factor","volume":"20","author":"Marston","year":"2017","journal-title":"J. Sci. Med. Sport"},{"key":"B143","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1249\/JSR.0000000000000948","article-title":"An overview of blood flow restriction physiology and clinical considerations","volume":"21","author":"Martin","year":"2022","journal-title":"Curr. Sports Med. Rep."},{"key":"B144","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3389\/fendo.2019.00621","article-title":"Association of irisin serum concentration and muscle strength in normal-weight and overweight young women","volume":"10","author":"Mart\u00ednez Mu\u00f1oz","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B145","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s00421-018-3806-2","article-title":"Lower body blood flow restriction training may induce remote muscle strength adaptations in an active unrestricted arm","volume":"118","author":"May","year":"2018","journal-title":"Eur. J. Appl. physiology"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1152\/japplphysiol.00709.2022","article-title":"Intense interval exercise induces lactate accumulation and a greater suppression of acylated ghrelin compared with submaximal exercise in middle-aged adults","volume":"134","author":"McCarthy","year":"2023","journal-title":"J. Appl. Physiol."},{"key":"B147","article-title":"Biochemistry, anaerobic glycolysis","volume-title":"StatPearls","author":"Melkonian","year":"2024"},{"key":"B148","doi-asserted-by":"publisher","first-page":"5135","DOI":"10.1113\/JP270654","article-title":"Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?","volume":"594","author":"Merry","year":"2016","journal-title":"J. Physiol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"978","DOI":"10.26603\/001c.25791","article-title":"The systemic effects of blood flow restriction training: a systematic review","volume":"16","author":"Miller","year":"2021","journal-title":"Int. J. Sports Phys. Ther."},{"key":"B150","doi-asserted-by":"publisher","first-page":"6453","DOI":"10.1038\/s41598-021-85733-1","article-title":"High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles","volume":"11","author":"Moberg","year":"2021","journal-title":"Sci. Rep."},{"key":"B151","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1136\/bjsports-2021-105061","article-title":"Muscle-strengthening activities are associated with lower risk and mortality in major non-communicable diseases: a systematic review and meta-analysis of cohort studies","volume":"56","author":"Momma","year":"2022","journal-title":"Br. J. Sports Med."},{"key":"B152","doi-asserted-by":"publisher","first-page":"E807","DOI":"10.1152\/ajpendo.00591.2005","article-title":"PGC-1alpha and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype","volume":"291","author":"Mortensen","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B153","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1152\/japplphysiol.00154.2016","article-title":"Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men","volume":"121","author":"Morton","year":"2016","journal-title":"J. Appl. physiology Bethesda"},{"key":"B154","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1113\/JP278056","article-title":"Muscle fibre activation is unaffected by load and repetition duration when resistance exercise is performed to task failure","volume":"597","author":"Morton","year":"2019","journal-title":"J. Physiol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1111\/febs.12338","article-title":"Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?","volume":"280","author":"Mu\u00f1oz-C\u00e1noves","year":"2013","journal-title":"FEBS J."},{"key":"B156","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1123\/ijspp.2022-0161","article-title":"Effects of low- versus high-velocity-loss thresholds with similar training volume on maximal strength and hypertrophy in highly trained individuals","volume":"18","author":"Myrholt","year":"2023","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"B157","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/biology5040038","article-title":"Lactate as a signaling molecule that regulates exercise-induced adaptations","volume":"5","author":"Nalbandian","year":"2016","journal-title":"Biology"},{"key":"B158","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ebiom.2019.10.034","article-title":"Skeletal muscle as potential central link between sarcopenia and immune senescence","volume":"49","author":"Nelke","year":"2019","journal-title":"EBioMedicine"},{"key":"B159","doi-asserted-by":"publisher","first-page":"101935","DOI":"10.1016\/j.arr.2023.101935","article-title":"Pleiotropic and multi-systemic actions of physical exercise on PGC-1\u03b1 signaling during the aging process","volume":"87","author":"Neto","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"B160","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1152\/japplphysiol.00650.2003","article-title":"Central and peripheral contributions to fatigue in relation to level of activation during repeated maximal voluntary isometric plantar flexions","volume":"96","author":"Nordlund","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.pcad.2014.11.004","article-title":"Part 1: potential dangers of extreme endurance exercise: how much is too much? Part 2: screening of school-age athletes","volume":"57","author":"O\u2019Keefe","year":"2015","journal-title":"Prog. Cardiovasc Dis."},{"key":"B162","first-page":"155","article-title":"Training strategies to optimize cardiovascular Durability and life expectancy","volume":"120","author":"O\u2019Keefe","year":"2023","journal-title":"Mo Med."},{"key":"B163","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/jhh.2010.13","article-title":"Effect of isometric exercise on resting blood pressure: a meta analysis","volume":"24","author":"Owen","year":"2010","journal-title":"J. Hum. Hypertens."},{"key":"B164","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1080\/17461391.2018.1505957","article-title":"Exercise-induced muscle damage: what is it, what causes it and what are the nutritional solutions?","volume":"19","author":"Owens","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.mehy.2015.12.026","article-title":"Muscle growth across a variety of exercise modalities and intensities: contributions of mechanical and metabolic stimuli","volume":"88","author":"Ozaki","year":"2016","journal-title":"Med. Hypotheses"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.3390\/ijms21031170","article-title":"BDNF as a promising therapeutic agent in Parkinson\u2019s disease","volume":"21","author":"Palasz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B167","doi-asserted-by":"publisher","first-page":"134","DOI":"10.4330\/wjc.v9.i2.134","article-title":"Aerobic vs anaerobic exercise training effects on the cardiovascular system","volume":"9","author":"Patel","year":"2017","journal-title":"World J. Cardiol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"111509","DOI":"10.1016\/j.exger.2021.111509","article-title":"Sauna use as a lifestyle practice to extend healthspan","volume":"154","author":"Patrick","year":"2021","journal-title":"Exp. Gerontol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s00421-012-2479-5","article-title":"Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men","volume":"113","author":"Patterson","year":"2013","journal-title":"Eur. J. Appl. Physiol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s40279-014-0264-9","article-title":"A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy","volume":"45","author":"Pearson","year":"2015","journal-title":"Sports Med."},{"key":"B171","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/MCO.0000000000000546","article-title":"Which type of exercise keeps you young?","volume":"22","author":"Pedersen","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. and Metabolic Care"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol. Rev."},{"key":"B173","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ijcard.2005.07.035","article-title":"Short-term isometric exercise reduces systolic blood pressure in hypertensive adults: possible role of reactive oxygen species","volume":"110","author":"Peters","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1113\/JP279963","article-title":"The anaerobic threshold: 50+ years of controversy","volume":"599","author":"Poole","year":"2021","journal-title":"J. Physiol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/cphy.c100054","article-title":"Reactive oxygen species: impact on skeletal muscle","volume":"1","author":"Powers","year":"2011","journal-title":"Compr. Physiol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41392-024-01756-w","article-title":"Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases","volume":"9","author":"Qian","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"B177","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1096\/fj.08-106104","article-title":"Lactate fuels the human brain during exercise","volume":"22","author":"Quistorff","year":"2008","journal-title":"FASEB J."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1519\/JSC.0b013e3181ddb265","article-title":"Effects of very short rest periods on hormonal responses to resistance exercise in men","volume":"24","author":"Rahimi","year":"2010","journal-title":"J. Strength and Cond. Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1519\/JSC.0b013e31827e8681","article-title":"Regional fat changes induced by localized muscle endurance resistance training","volume":"27","author":"Ram\u00edrez-Campillo","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","article-title":"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis","volume":"157","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"B181","doi-asserted-by":"publisher","first-page":"320724","DOI":"10.1155\/2013\/320724","article-title":"Adipo-myokines: two sides of the same coin--mediators of inflammation and mediators of exercise","volume":"2013","author":"Raschke","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"B182","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1519\/JSC.0000000000003920","article-title":"Metabolic profile of reciprocal supersets in young, recreationally active women and men","volume":"36","author":"Realzola","year":"2022","journal-title":"J. Strength and Cond. Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"R502","DOI":"10.1152\/ajpregu.00114.2004","article-title":"Biochemistry of exercise-induced metabolic acidosis","volume":"287","author":"Robergs","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1152\/physrev.00039.2022","article-title":"Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions","volume":"103","author":"Roberts","year":"2023","journal-title":"Physiol. Rev."},{"key":"B185","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1007\/s40279-024-02069-2","article-title":"Exploring the dose\u2013response relationship between Estimated resistance training proximity to failure, strength gain, and muscle hypertrophy: a Series of meta-Regressions","volume":"54","author":"Robinson","year":"2024","journal-title":"Sports Med."},{"key":"B186","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.3390\/biomedicines11082267","article-title":"Examining the interaction between exercise, gut microbiota, and neurodegeneration: future research directions","volume":"11","author":"Rojas-Valverde","year":"2023","journal-title":"Biomedicines"},{"key":"B187","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1007\/s00421-011-1860-0","article-title":"Physiological elevation of endogenous hormones results in superior strength training adaptation","volume":"111","author":"R\u00f8nnestad","year":"2011","journal-title":"Eur. J. Appl. physiology"},{"key":"B188","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.3389\/fphys.2018.01376","article-title":"The role of inflammation and immune cells in blood flow restriction training adaptation: a review","volume":"9","author":"Rossi","year":"2018","journal-title":"Front. Physiol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1249\/MSS.0000000000001642","article-title":"High-intensity interval training in the real World: outcomes from a 12-Month intervention in overweight adults","volume":"50","author":"Roy","year":"2018","journal-title":"Med. Sci. Sports Exerc"},{"key":"B190","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.tem.2020.11.010","article-title":"Effects of blood flow restriction exercise and possible applications in type 2 diabetes","volume":"32","author":"Saatmann","year":"2021","journal-title":"Trends Endocrinol. and Metabolism"},{"key":"B191","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/sports12020057","article-title":"Cognitive fitness: Harnessing the strength of exerkines for aging and metabolic challenges","volume":"12","author":"Saheli","year":"2024","journal-title":"Sports (Basel)"},{"key":"B192","doi-asserted-by":"publisher","first-page":"S135","DOI":"10.1249\/00005768-198810001-00009","article-title":"Neural adaptation to resistance training","volume":"20","author":"Sale","year":"1988","journal-title":"Med. Sci. sports Exerc."},{"key":"B193","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell Physiol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1159\/000047804","article-title":"Reactive oxygen species as intracellular messengers during cell growth and differentiation","volume":"11","author":"Sauer","year":"2001","journal-title":"Cell Physiol. Biochem."},{"key":"B195","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1519\/ssc.0b013e3182221ec2","article-title":"The Use of Specialized training techniques to maximize muscle hypertrophy","volume":"33","author":"Schoenfeld","year":"2011","journal-title":"Strength and Cond. J."},{"key":"B196","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s40279-013-0017-1","article-title":"Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training","volume":"43","author":"Schoenfeld","year":"2013","journal-title":"Sports Med."},{"key":"B197","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1519\/JSC.0000000000002200","article-title":"Strength and hypertrophy adaptations between low-vs. High-load resistance training: a systematic review and meta-analysis","volume":"31","author":"Schoenfeld","year":"2017","journal-title":"J. Strength Cond. Res."},{"key":"B198","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/sports9020032","article-title":"Loading recommendations for muscle strength, hypertrophy, and local endurance: a Re-Examination of the repetition continuum","volume":"9","author":"Schoenfeld","year":"2021","journal-title":"Sports (Basel)"},{"key":"B199","doi-asserted-by":"publisher","first-page":"827847","DOI":"10.3389\/fphys.2022.827847","article-title":"Higher muscle damage triggered by shorter inter-set rest periods in volume-equated resistance exercise","volume":"13","author":"Senna","year":"2022","journal-title":"Front. Physiol."},{"key":"B200","first-page":"167","article-title":"Effect of a low-intensity resistance exercise programme with blood flow restriction on growth hormone and insulin-like growth factor-1 levels in middle-aged women","volume":"38","author":"Seo","year":"2016","journal-title":"South Afr. J. Res. Sport, Phys. Educ. Recreat."},{"key":"B201","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cmet.2007.11.011","article-title":"Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy","volume":"7","author":"Serrano","year":"2008","journal-title":"Cell Metab."},{"key":"B202","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.amepre.2022.03.020","article-title":"Resistance training and mortality risk: a systematic review and meta-analysis","volume":"63","author":"Shailendra","year":"2022","journal-title":"Am. J. Prev. Med."},{"key":"B203","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.imr.2014.09.007","article-title":"Exercise-induced myokines in health and metabolic diseases","volume":"3","author":"So","year":"2014","journal-title":"Integr. Med. Res."},{"key":"B204","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40798-023-00620-5","article-title":"Effects of drop sets on skeletal muscle hypertrophy: a systematic review and meta-analysis","volume":"9","author":"S\u00f8dal","year":"2023","journal-title":"Sports Med. Open"},{"key":"B205","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jsbmb.2009.02.005","article-title":"Elevated endogenous testosterone concentrations potentiate muscle androgen receptor responses to resistance exercise","volume":"114","author":"Spiering","year":"2009","journal-title":"J. steroid Biochem. Mol. Biol."},{"key":"B206","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.steroids.2015.02.019","article-title":"Upper-body resistance exercise augments vastus lateralis androgen receptor\u2013DNA binding and canonical Wnt\/\u03b2-catenin signaling compared to lower-body resistance exercise in resistance-trained men without an acute increase in serum testosterone","volume":"98","author":"Spillane","year":"2015","journal-title":"Steroids"},{"key":"B207","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/biom5020356","article-title":"Impact of oxidative stress on exercising skeletal muscle","volume":"5","author":"Steinbacher","year":"2015","journal-title":"Biomolecules"},{"key":"B208","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.2741\/4657","article-title":"Survival of the fittest: VO2max, a key predictor of longevity?","volume":"23","author":"Strasser","year":"2018","journal-title":"Front. Biosci. Landmark Ed."},{"key":"B209","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s40279-018-0862-z","article-title":"The importance of muscular strength: training considerations","volume":"48","author":"Suchomel","year":"2018","journal-title":"Sports Med."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1519\/JSC.0b013e318239c38e","article-title":"Muscle activation strategies during strength training with heavy loading vs. repetitions to failure","volume":"26","author":"Sundstrup","year":"2012","journal-title":"J. Strength Cond. Res."},{"key":"B211","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1519\/1533-4287(2002)016<0123:eolire>2.0.co;2","article-title":"Effects of low-intensity resistance exercise with short Interset rest period on muscular function in middle-aged women","volume":"16","author":"Takarada","year":"2002","journal-title":"J. Strength and Cond. Res."},{"key":"B212","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.neubiorev.2011.10.004","article-title":"Supraspinal regulation of physical fatigue","volume":"36","author":"Tanaka","year":"2012","journal-title":"Neurosci. Biobehav Rev."},{"key":"B213","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1249\/MSS.0000000000000923","article-title":"Neural contributions to muscle fatigue: from the brain to the muscle and back Again","volume":"48","author":"Taylor","year":"2016","journal-title":"Med. Sci. Sports Exerc"},{"key":"B214","doi-asserted-by":"publisher","first-page":"827","DOI":"10.2165\/00007256-200737100-00001","article-title":"Metabolic consequences of exercise-induced muscle damage","volume":"37","author":"Tee","year":"2007","journal-title":"Sports Med."},{"key":"B215","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/sports6040153","article-title":"Monitoring exercise-induced muscle fatigue and adaptations: making Sense of popular or emerging Indices and Biomarkers","volume":"6","author":"Theofilidis","year":"2018","journal-title":"Sports (Basel)"},{"key":"B216","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1210\/endo.142.8.8319","article-title":"Human follistatin-related protein: a structural homologue of follistatin with nuclear localization","volume":"142","author":"Tortoriello","year":"2001","journal-title":"Endocrinology"},{"key":"B217","volume-title":"Essentials of Strength training and conditioning","author":"Triplett","year":"2015"},{"key":"B218","doi-asserted-by":"publisher","first-page":"e247","DOI":"10.1016\/S2666-7568(23)00057-0","article-title":"Effects of physical exercise on physical function in older adults in residential care: a systematic review and network meta-analysis of randomised controlled trials","volume":"4","author":"Valenzuela","year":"2023","journal-title":"Lancet Healthy Longev."},{"key":"B219","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1007\/s40279-024-02110-4","article-title":"Optimizing resistance training for Sprint and endurance athletes: Balancing positive and negative adaptations","volume":"54","author":"Van Hooren","year":"2024","journal-title":"Sports Med."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1136\/bjsports-2015-095898","article-title":"Evidence-based clinical practice update: practice guidelines for anterior cruciate ligament rehabilitation based on a systematic review and multidisciplinary consensus","volume":"50","author":"van Melick","year":"2016","journal-title":"Br. J. Sports Med."},{"key":"B221","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/jnr.20979","article-title":"Revenge of the \u2018sit\u2019: how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity","volume":"84","author":"Vaynman","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"B222","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/mus.21054","article-title":"Effects of combined lower body endurance and upper body resistance training on the satellite cell pool in elderly subjects","volume":"38","author":"Verney","year":"2008","journal-title":"Muscle and Nerve"},{"key":"B223","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s00421-006-0175-z","article-title":"Combined lower body endurance and upper body resistance training improves performance and health parameters in healthy active elderly","volume":"97","author":"Verney","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1152\/japplphysiol.00685.2018","article-title":"Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise","volume":"126","author":"Wackerhage","year":"2019","journal-title":"J. Appl. Physiology"},{"key":"B225","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1249\/MSS.0b013e3181e71bcb","article-title":"Neuromuscular and hormonal responses to constant and variable resistance loadings","volume":"43","author":"Walker","year":"2011","journal-title":"Med. Sci. Sports Exerc"},{"key":"B226","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/sports7010014","article-title":"Repeated Bouts of advanced strength training techniques: effects on volume load, metabolic responses, and muscle activation in trained individuals","volume":"7","author":"Wallace","year":"2019","journal-title":"Sports (Basel)"},{"key":"B227","doi-asserted-by":"publisher","first-page":"104954","DOI":"10.1016\/j.archger.2023.104954","article-title":"Effect of resistance training on local muscle endurance in middle-aged and older adults: a systematic review with meta-analysis and meta-regression","volume":"109","author":"Wang","year":"2023","journal-title":"Arch. Gerontol. Geriatr."},{"key":"B228","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jshs.2018.09.008","article-title":"MicroRNAs in heart and circulation during physical exercise","volume":"7","author":"Wang","year":"2018","journal-title":"J. Sport Health Sci."},{"key":"B229","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40798-024-00706-8","article-title":"Effects of chronic Static Stretching on maximal strength and muscle hypertrophy: a systematic review and meta-analysis with meta-regression","volume":"10","author":"Warneke","year":"2024","journal-title":"Sports Med. - Open"},{"key":"B230","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s40798-023-00578-4","article-title":"Physiological responses and adaptations to lower load resistance training: implications for health and performance","volume":"9","author":"Weakley","year":"2023","journal-title":"Sports Med. - Open"},{"key":"B231","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1007\/s00421-017-3680-3","article-title":"The effects of traditional, superset, and tri-set resistance training structures on perceived intensity and physiological responses","volume":"117","author":"Weakley","year":"2017","journal-title":"Eur. J. Appl. Physiol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"e13302","DOI":"10.1111\/apha.13302","article-title":"Muscle fibre activation and fatigue with low-load blood flow restricted resistance exercise-An integrative physiology review","volume":"228","author":"Wernbom","year":"2020","journal-title":"Acta Physiol. (Oxf)"},{"key":"B233","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1152\/japplphysiol.01147.2009","article-title":"Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors","volume":"108","author":"West","year":"2010","journal-title":"J. Appl. physiology Bethesda"},{"key":"B234","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1249\/JSR.0b013e31825dabb8","article-title":"Resistance training is medicine: effects of strength training on health","volume":"11","author":"Westcott","year":"2012","journal-title":"Curr. Sports Med. Rep."},{"key":"B235","doi-asserted-by":"publisher","first-page":"616","DOI":"10.52082\/jssm.2022.616","article-title":"Resistance exercise-induced increases in muscle myostatin mRNA and protein expression are subsequently decreased in circulation in the presence of increased levels of the Extracellular Matrix Stabilizing protein decorin","volume":"21","author":"Willoughby","year":"2022","journal-title":"J. Sports Sci. Med."},{"key":"B236","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12986-022-00687-z","article-title":"The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule","volume":"19","author":"Xue","year":"2022","journal-title":"Nutr. and metabolism"},{"key":"B237","doi-asserted-by":"publisher","first-page":"e188341","DOI":"10.1001\/jamanetworkopen.2018.8341","article-title":"Association between push-up exercise capacity and future cardiovascular events among active adult men","volume":"2","author":"Yang","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"B250","doi-asserted-by":"crossref","first-page":"101030","DOI":"10.1016\/j.jshs.2025.101030","article-title":"Physiological adaptations and performance enhancement with combined blood flow restricted and interval training: a systematic review with meta-analysis","author":"Yin","year":"2025","journal-title":"J. Sport Health Sci."},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-025-02176-8","article-title":"Superset versus traditional resistance training Prescriptions\u2014a systematic review and meta-analysis exploring acute and chronic effects on mechanical, metabolic, and Perceptual variables","author":"Zhang","year":"2025","journal-title":"Sports Med"},{"key":"B239","doi-asserted-by":"publisher","first-page":"542","DOI":"10.14744\/AnatolJCardiol.2024.4458","article-title":"The effect of low-intensity interval exercise with blood flow restriction on plasma cardiac Troponin: a cross-design trial","volume":"28","author":"Zhou","year":"2024","journal-title":"Anatol. J. Cardiol."},{"key":"B240","doi-asserted-by":"publisher","first-page":"215814","DOI":"10.1016\/j.canlet.2022.215814","article-title":"Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information","volume":"544","author":"Zhu","year":"2022","journal-title":"Cancer Lett."},{"key":"B241","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.ajpath.2011.04.008","article-title":"Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis","volume":"179","author":"Zhu","year":"2011","journal-title":"Am. J. pathology"},{"key":"B242","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.3390\/ijms23073501","article-title":"Myokines and resistance training: a narrative review","volume":"23","author":"Zunner","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2025.1549609\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:12:05Z","timestamp":1744888325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2025.1549609\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":243,"alternative-id":["10.3389\/fphys.2025.1549609"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2025.1549609","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"article-number":"1549609"}}