{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:27:42Z","timestamp":1754144862837,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the clinical efficacy of modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in treating severe pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single-center, prospective, double-blind, randomized controlled trial. A total of 138 patients with severe pneumonia were randomly divided into two groups. The control group (n = 69) received ambroxol hydrochloride, while the observation group (n = 69) received modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride. Clinical efficacy, Traditional Chinese Medicine symptom scores (fever, cough, expectoration, dyspnea), arterial blood gas indicators [oxygen saturation (SaO<jats:sub>2<\/jats:sub>), partial pressure of oxygen (PaO<jats:sub>2<\/jats:sub>), partial pressure of carbon dioxide (PaCO<jats:sub>2<\/jats:sub>)], lung function [forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF)], and inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-\u03b1 (TNF-\u03b1), C-reactive protein (CRP)] were evaluated. Adverse events were recorded for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall efficacy rates in the combined and control groups were 98.55% and 89.86% (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). After treatment, in both groups, symptom scores for fever, cough, expectoration, and dyspnea were reduced, with the combined group showing more significant improvement; SaO<jats:sub>2<\/jats:sub> and PaO<jats:sub>2<\/jats:sub> levels increased, and PaCO<jats:sub>2<\/jats:sub> decreased, with the combined group achieving greater improvement; FEV1, FVC, and PEF values increased, with higher values observed in the combined group; serum IL-6, TNF-\u03b1, and CRP levels decreased, with the combined group showing more substantial reductions (all <jats:italic>P<\/jats:italic> &amp;lt; 0.05). The incidence of adverse events was 4.35% in the combined group and 2.90% in the control group (<jats:italic>P<\/jats:italic> &amp;gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride demonstrated ideal clinical efficacy in treating severe pneumonia, alleviating symptoms and pulmonary inflammation and improving arterial blood gas indicators and lung function.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphys.2025.1601761","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:36:09Z","timestamp":1752644169000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia"],"prefix":"10.3389","volume":"16","author":[{"given":"Binyu","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cunyi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"31497","DOI":"10.1039\/d2ra05216d","article-title":"Development of a hematite nanotube and tyramine-based drug carrier against drug-resistant bacteria Klebsiella pneumoniae","volume":"12","author":"Ali","year":"2022","journal-title":"RSC Adv."},{"key":"B2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.4103\/ijmr.IJMR_1678_19","article-title":"Community-acquired bacterial pneumonia in adults: an update","volume":"151","author":"Eshwara","year":"2020","journal-title":"Indian J. 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