{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:58:28Z","timestamp":1785412708448,"version":"3.56.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This paper aims to assess the impact of bisoprolol combined with torasemide on cardiac electrophysiological parameters in acute myocardial infarction (AMI) patients complicated by heart failure (HF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 140 AMI-HF patients were randomized to either the control group (bisoprolol alone for 3 months, n = 70) or an experimental group (bisoprolol for 3 months plus torasemide for 2 weeks, n = 70). The corrected QT (QTc) interval, QT dispersion, B-type natriuretic peptide (BNP) levels, left ventricular ejection fraction (LVEF), serum creatinine, serum potassium, New York Heart Association (NYHA) classification, Borg dyspnea score, lower-limb edema resolution, systolic\/diastolic blood pressure (SBP\/DBP), heart rate (HR), incidence of ventricular arrhythmia (VA) and atrial flutter\/fibrillation (AFL\/AF), and cardiovascular and all-cause mortality were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups demonstrated statistically significant reductions in QTc interval, QT dispersion, BNP, NYHA class, Borg score, SBP, DBP, HR, along with increased LVEF at 2 weeks and 3 months post-treatment versus baseline, with the experimental group showing moderate improvement at 2 weeks post-treatment in all parameters than the control group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The experimental group had high serum potassium levels and a greater rate of lower-limb edema-resolution at 2 weeks post-treatment than the control group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). No significant differences were observed between groups in cardiovascular or all-cause mortality (<jats:italic>P<\/jats:italic> &amp;gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bisoprolol combined with torasemide improves cardiac electrophysiological parameters, cardiac function, symptoms, and hemodynamics in AMI-HF patients as early as 2 weeks into treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fphys.2025.1629758","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T05:30:43Z","timestamp":1754458243000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of bisoprolol combined with torasemide on cardiac electrophysiology in patients with acute myocardial infarction and heart failure"],"prefix":"10.3389","volume":"16","author":[{"given":"Li","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangwei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"B1","first-page":"1","article-title":"Update: prolonged-release torasemide","volume":"46","author":"Acuna","year":"2010","journal-title":"Drugs Today (Barc)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"661","DOI":"10.5603\/CJ.a2019.0114","article-title":"Comparative effectiveness of torasemide versus furosemide in symptomatic therapy in heart failure patients: preliminary results from the randomized TORNADO trial","volume":"26","author":"Balsam","year":"2019","journal-title":"Cardiol. 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