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Physiol."],"abstract":"<jats:p>This study aimed to determine whether chronic <jats:italic>Rhodiola rosea<\/jats:italic> (salidroside) supplementation augments neuromuscular and metabolic adaptations to flywheel eccentric (ECC) training. In total, 30 recreationally active female students were randomly assigned to (1) sedentary placebo control (SC, n = 10), (2) ECC training + placebo (ECC, n = 10), or (3) ECC training + salidroside (150 mg day<jats:sup>\u22121<\/jats:sup>; ECC + SA, n = 10) for 4 weeks. Pre- and post-intervention assessments included exhaustive cycling time to volitional fatigue, peak oxygen uptake (VO<jats:sub>2<\/jats:sub> max), drop vertical jump (DJ) reactive strength index (RSI), and blood biomarkers of muscle damage and metabolism. ECC and ECC + SA prolonged time to exhaustion by 33% and 45%, respectively, without altering VO<jats:sub>2<\/jats:sub> max. Across DJ<jats:sub>1<\/jats:sub>\u2013DJ<jats:sub>160<\/jats:sub>, RSI significantly increased in both ECC groups (<jats:italic>p<\/jats:italic> &amp;lt; 0.01). Salidroside conferred an additional 8%\u201333% RSI advantage during the final 40 contacts (DJ<jats:sub>120<\/jats:sub>\u2013DJ<jats:sub>160<\/jats:sub>; <jats:italic>p<\/jats:italic> &amp;lt; 0.05). The ECC + SA group exhibited lower postcycling creatine kinase (CK) and higher free fatty acids (FFA) than the SC group (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Triacylglycerol and low-density lipoprotein cholesterol decreased in ECC + SA compared with SC (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), whereas body composition remained unchanged. In conclusion, four weeks of ECC training improved endurance and stretch\u2013shortening performance. Salidroside further enhanced late-stage RSI, with additive antifatigue and muscle-protective effects during high-load eccentric conditioning in recreationally active women.<\/jats:p>","DOI":"10.3389\/fphys.2025.1663086","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:07:34Z","timestamp":1757311654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women"],"prefix":"10.3389","volume":"16","author":[{"given":"I-Lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maobing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1023\/b:bebm.0000046940.45382.53","article-title":"Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood","volume":"138","author":"Abidov","year":"2004","journal-title":"Bull. 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