{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:31:32Z","timestamp":1792222292092,"version":"4.4.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skeletal muscle mitochondrial dysfunction is a key driver of insulin resistance and disease progression in type 2 diabetes mellitus (T2DM), while exercise training has shown potential to improve mitochondrial function. However, existing studies focus on single exercise modalities, lack systematic synthesis of mitochondrial mechanisms, and exhibit conflicting results, highlighting the need for a comprehensive meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic searches were conducted in PubMed, Web of Science, and Scopus for studies involving T2DM patients (\u226540 years) with exercise as the primary intervention and mitochondrial outcomes. Methodological quality was assessed via the TESTEX scale, with meta-analysis performed using Stata 17.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 18 studies (394 participants, 272 in training groups) were included. Exercise significantly enhanced mitochondrial oxidative capacity (SMD = 0.61, 95% CI [0.30, 0.92], driven by citrate synthase [CS] and COX-II), antioxidant capacity (SMD = 1.18, 95% CI [0.50, 1.86], mainly via SOD2), and fusion marker MFN2 (SMD = 0.96, 95% CI [0.63, 1.29]). It tended to increase mitochondrial content (SMD = 0.50,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.091) but with no significant mtDNA\/PGC-1\u03b1 changes. Effective modalities included long-term moderate aerobic training, short-term HIIT, and long-term resistance\/combined training. Antidiabetic medications\u2019 potential interference was underassessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate-to-high intensity exercise selectively improves skeletal muscle mitochondrial function in T2DM, particularly oxidative capacity (via CS\/COX-II), antioxidant capacity (via SOD2), and mitochondrial fusion (via MFN2). The effect on mitochondrial content is non-significant, and the influence of antidiabetic medications requires further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>Identifier CRD42024579581.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2025.1671926","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:29:43Z","timestamp":1761060583000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of exercise training on skeletal muscle mitochondrial outcomes in type 2 diabetes: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Wenning","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangxu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.3390\/medicina59071320","article-title":"High-intensity Interval training improves glycemic control, cellular apoptosis, and oxidative stress of type 2 diabetic patients","volume":"59","author":"Al-Rawaf","year":"2023","journal-title":"Medicina-Lithuania."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1040381","DOI":"10.3389\/fphys.2022.1040381","article-title":"Exercise and mitochondrial mechanisms in patients with sarcopenia","volume":"13","author":"Alizadeh Pahlavani","year":"2022","journal-title":"Front. 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