{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:54:10Z","timestamp":1788497650459,"version":"build-2803163510"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    The purpose of this pilot study was to develop and characterize an\n                    <jats:italic>in vivo<\/jats:italic>\n                    porcine model of hyperoxaluria using intravenous infusion of sodium oxalate (NaOx). Two experimental regimens were developed to replicate acute and follow up chronic hyperoxaluria. In the acute model, 3 different doses of 1% NaOx were administered over 15 h, resulting in a dose-dependent increase in plasma oxalate concentration (Cmax: 42.4\u2013122.4 \u00b5M) and transient hyperoxaluria, with a return to baseline values 6\u20138 h after stopping the infusion of NaOx solution. In the chronic model, repeated infusions of NaOx for 7\u201311 days directly after acute tests led to persistent hyperoxalemia (up to 302.4 \u00b5M), clinical deterioration and dose-dependent calcium oxalate (CaOx) deposits in renal tissue (1.85%\u20139.55% of renal surface area), consistent with impaired renal function. The model represents the key clinical features of both rapidly inducible and reversible hyperoxalemia and hyperoxaluria, as well as the progressive nephrocalcinosis. Due to the physiological similarity between pigs and humans, the proposed porcine model could be considered as a quick and valuable tool for studying the pathophysiology of oxalate excess and testing the efficacy of new therapies to counteract its toxicity.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2025.1692403","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:35:05Z","timestamp":1768973705000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The domestic pig as a translational model of hyperoxaluria: a pilot study of acute and chronic sodium oxalate infusion"],"prefix":"10.3389","volume":"16","author":[{"given":"Tomasz","family":"Jacek","sequence":"first","affiliation":[{"name":"National Research Institute of Animal Production","place":["Balice, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Szkopek","sequence":"additional","affiliation":[{"name":"Large Animal Models Laboratory, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences","place":["Jab\u0142onna, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Wychowa\u0144ski","sequence":"additional","affiliation":[{"name":"Catholic University of the \u201cSacred Heart\u201d, Department of Head and Neck and Sensory Organs","place":["Rome, Italy"]},{"name":"Department of Interventional Dentistry, Collegium Medicum, Nicolaus Copernicus University","place":["Bydgoszcz, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Health Sciences, School of Biomedical Sciences, University of the Witwatersrand","place":["Johannesburg, South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Zaworski","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences","place":["Jab\u0142onna, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Struty\u0144ski","sequence":"additional","affiliation":[{"name":"Anara AB","place":["Trelleborg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siarhei","family":"Kirko","sequence":"additional","affiliation":[{"name":"Anara AB","place":["Trelleborg, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Prykhodko","sequence":"additional","affiliation":[{"name":"Department of Biology, Lund University","place":["Lund, Sweden"]},{"name":"Division of Food and Pharma, Department of Process and Life Science Engineering, Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olexandr","family":"Fedkiv","sequence":"additional","affiliation":[{"name":"Department of Biology, Lund University","place":["Lund, Sweden"]},{"name":"Division of Food and Pharma, Department of Process and Life Science Engineering, Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan G.","family":"Pierzynowski","sequence":"additional","affiliation":[{"name":"Anara AB","place":["Trelleborg, Sweden"]},{"name":"Department of Biology, Lund University","place":["Lund, Sweden"]},{"name":"Department of Medical Biology, Institute of Rural Health","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna","family":"Pierzynowska","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences","place":["Jab\u0142onna, Poland"]},{"name":"Anara AB","place":["Trelleborg, Sweden"]},{"name":"Department of Biology, Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.juro.2007.11.040","article-title":"Pig kidney: anatomical relationships between the renal venous arrangement and the kidney collecting system","volume":"179","author":"Bagetti Filho","year":"2008","journal-title":"J. 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