{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:17:34Z","timestamp":1771395454641,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pulsed-field ablation (PFA) is a novel ablation modality with promising outcomes for atrial fibrillation therapy. However, PFA might lead to dry cough and diaphragmatic contraction, especially under conscious sedation. We aim to explore a novel approach to reduce dry cough and diaphragmatic contraction during PFA procedures performed under conscious sedation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 16 patients who underwent PFA pulmonary vein isolation under conscious sedation were divided into the asmeton (with preprocedure asmeton) and control groups. A scoring system was developed to assess dry cough and diaphragmatic contraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 608 ablations and 893 ablations were performed in the control and asmeton groups, respectively. The dry cough score (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.045) in all pulmonary veins was significantly reduced by 73.1% in the asmeton group in comparison with the control group. The proportion of medium-to-high dry cough incidences decreased from 12.2 \u00b1 10.4% in the control group to 1.8 \u00b1 3.7% in the asmeton group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.027). The diaphragmatic contraction score in the asmeton group was 37.5% lower than that in the control group, and the proportion of severe diaphragmatic contraction incidences was significantly reduced from 2.8 \u00b1 8.4% in the control group to 0.0 \u00b1 0.0% in the asmeton group (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Asmeton might eliminate moderate-to-severe dry cough and reduce the severity of diaphragmatic contraction during pulmonary vein isolation under conscious sedation ablation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2025.1702254","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:33:00Z","timestamp":1771392780000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Asmeton minimizes dry cough and diaphragmatic contraction during pulsed-field ablation of atrial fibrillation: a clinical prospective randomized study"],"prefix":"10.3389","volume":"16","author":[{"given":"Huixing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Cardiac Autonomic Nervous System Research Center of Wuhan University","place":["Wuhan, China"]},{"name":"Cardiovascular Research Institute, Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Cardiology","place":["Wuhan, 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