{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:48:57Z","timestamp":1768308537654,"version":"3.49.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical application value of capsule endoscopy (CE) in the diagnosis of small intestinal diseases in children in Wuhan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on the clinical data of children who underwent CE examination at the Digestive Endoscopy Center of Wuhan Children\u2019s Hospital from July 2021 to November 2024. The completion rate of CE examination, disease detection rate, small intestinal transit time, and adverse reactions were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 151 children, 97 were male (64.24%) and 54 were female (35.76%), with an average age of 10.9 years. CE was swallowed orally in 133 cases (88.08%) and placed through gastroscopy in 18 cases (11.92%). Complete small intestinal examination was achieved in 144 cases (95.36%), with an average small intestinal transit time of 4 h and 11 min for those swallowed orally and 4 h and 16 min for those placed through gastroscopy. Seven cases (4.64%) did not complete the full small intestinal examination. Abdominal pain (99 cases, 65.56%), anemia (19 cases, 12.58%), and hematochezia and melena (23 cases, 15.23%) were the most common indications for examination. Among the 151 children, 116 (76.82%) had positive results, including 68 cases of nonspecific small intestinal inflammation, 29 cases of Crohn\u2019s disease, 4 cases of Henoch-Sch\u00f6nlein purpura, 6 cases of Meckel\u2019s diverticulum, 4 cases of small intestinal parasitic disease, 2 cases of collagenous gastritis, 1 case of melanocytic polyp, 1 case of lymphangiectasia, and 1 case of blue rubber bleb nevus syndrome. Nonspecific small intestinal inflammation was the most common in all age groups, while Crohn\u2019s disease was mainly seen in the 7\u201312 years and 13\u201318 years age groups, accounting for 55.17% and 44.83%, respectively. No adverse reactions occurred in all children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CE examination in children in Wuhan has a high disease detection rate and good safety. CE can be further promoted in the diagnosis of small intestinal diseases in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2025.1714118","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:34:32Z","timestamp":1768286072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical application of capsule endoscopy in children with small bowel disease in Wuhan, China"],"prefix":"10.3389","volume":"16","author":[{"given":"Pingping","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.14740\/gr1487","article-title":"Video capsule endoscopy in gastroenterology","volume":"15","author":"Ahmed","year":"2022","journal-title":"Gastroenterol. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1136\/archdischild-2023-325668","article-title":"Inflammatory bowel disease: recent developments","volume":"109","author":"Ashton","year":"2024","journal-title":"Arch. Dis. Child."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.1038\/s41467-024-49019-0","article-title":"Robotic wireless capsule endoscopy: recent advances and upcoming technologies","volume":"15","author":"Cao","year":"2024","journal-title":"Nat. Commun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.3390\/diagnostics12051105","article-title":"Indications, detection, completion and retention rates of capsule endoscopy in two decades of use: a systematic review and meta-analysis","volume":"12","author":"Cortegoso Valdivia","year":"2022","journal-title":"Diagn. (Basel)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"862","DOI":"10.19538\/j.ek2018110613","article-title":"Application of capsule endoscopy in the diagnosis of gastrointestinal diseases in children","volume":"33","author":"Feng","year":"2018","journal-title":"Chin. J. Pract. Pediatr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3969\/j.issn.1672-2159.2017.06.026","article-title":"Application of capsule endoscopy in children","volume":"22","author":"He","year":"2017","journal-title":"Mod. Dig. and Intervention"},{"key":"B7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/35013140","article-title":"Wireless capsule endoscopy","volume":"405","author":"Iddan","year":"2000","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/den.14511","article-title":"Small bowel endoscopy for children: collaboration of capsule endoscopy and device-assisted enteroscopy","volume":"35","author":"Iwama","year":"2023","journal-title":"Dig. Endosc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3390\/children11040481","article-title":"Health literacy of children and adolescents with inflammatory bowel disease (IBD) and parents of IBD patients-coping and information needs","volume":"11","author":"Kaul","year":"2024","journal-title":"Child. (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12876-020-01326-8","article-title":"Indications and diagnostic yield of small-bowel capsule endoscopy in a real-world setting","volume":"20","author":"Kharazmi","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.3390\/diagnostics11101765","article-title":"Capsule endoscopy: pitfalls and approaches to overcome","volume":"11","author":"Kim","year":"2021","journal-title":"Diagn. (Basel)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3390\/children9050617","article-title":"Therapy strategies for children suffering from inflammatory bowel Disease (IBD)-A narrative review","volume":"9","author":"L\u00e9geret","year":"2022","journal-title":"Child. (Basel)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3760\/cma.j.issn.0578-1426.2020.02.001","article-title":"Research and development of capsule endoscopy in the past two decades: age of adulthood, heart of establishment","volume":"59","author":"Liao","year":"2020","journal-title":"Chin. J. Intern Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jfma.2024.06.012","article-title":"Clinical application and feasibility of capsule endoscopy in children at a medical center in central Taiwan","volume":"124","author":"Liao","year":"2025","journal-title":"J. Formos. Med. Assoc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3760\/cma.j.issn.0578-1310.2009.10.007","article-title":"Clinical value of wireless capsule endoscopy in diagnosis of small bowel disease in children","volume":"47","author":"Ma","year":"2009","journal-title":"Chin. J. Pediatr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"424","DOI":"10.4253\/wjge.v16.i7.424","article-title":"Clinical and demographic features of patients undergoing video-capsule endoscopy management: a descriptive study","volume":"16","author":"Mej\u00eda","year":"2024","journal-title":"World J. Gastrointest. Endosc."},{"key":"B17","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.gie.2020.12.001","article-title":"Video capsule endoscopy","volume":"93","author":"Melson","year":"2021","journal-title":"Gastrointest. Endosc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.5223\/pghn.2023.26.4.181","article-title":"Predictors of small bowel transit time for capsule endoscopy in children with inflammatory bowel disease","volume":"26","author":"Oka","year":"2023","journal-title":"Pediatr. Gastroenterol. Hepatol. Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6396651","DOI":"10.1155\/2022\/6396651","article-title":"The influence of obesity on small Bowel capsule endoscopy","volume":"2022","author":"Omori","year":"2022","journal-title":"Gastroenterol. Res. Pract."},{"key":"B20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3760\/cma.j.cn321463-20221128-00699","article-title":"Research progress in the application of capsule endoscopy in children","volume":"40","author":"Ou","year":"2023","journal-title":"Chin. J. Dig. Endosc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1055\/a-1973-3796","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - update 2022","volume":"55","author":"Pennazio","year":"2023","journal-title":"Endoscopy"},{"key":"B22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/MOG.0000000000000921","article-title":"Retention of small bowel capsule endoscopy","volume":"39","author":"Rosa","year":"2023","journal-title":"Curr. Opin. Gastroenterol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"7328","DOI":"10.3390\/jcm12237328","article-title":"Small bowel capsule endoscopy and enteroscopy: a shoulder-to-shoulder race","volume":"12","author":"Singeap","year":"2023","journal-title":"J. Clin. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"348","DOI":"10.21037\/atm.2020.02.40","article-title":"Variation in small bowel transit time on capsule endoscopy","volume":"8","author":"Tominaga","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s12876-020-01491-w","article-title":"Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3760\/cma.j.issn.0578-1310.2016.05.020","article-title":"Progress in the application of capsule endoscopy in pediatric small intestine diseases","volume":"54","author":"Wu","year":"2016","journal-title":"Chin. J. Pediatr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e22864","DOI":"10.1097\/MD.0000000000022864","article-title":"Clinical features of capsule endoscopy in 825 children: a single-center, retrospective cohort study","volume":"99","author":"Wu","year":"2020","journal-title":"Med. Baltim."},{"key":"B28","doi-asserted-by":"publisher","first-page":"957","DOI":"10.7499\/j.issn.1008-8830.2003065","article-title":"Value of capsule endoscopy in children with small intestinal diseases with hematochezia as the chief complaint","volume":"22","author":"Wu","year":"2020","journal-title":"Chin. J. Contemp. Pediatr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3760\/cma.j.issn.1007-5232.2017.02.001","article-title":"Development and prospect of pediatric gastrointestinal endoscopy","volume":"34","author":"Xu","year":"2017","journal-title":"Chin. J. Dig. Endosc."},{"key":"B30","doi-asserted-by":"publisher","first-page":"978","DOI":"10.3760\/cma.j.cn321463-20211206-00597","article-title":"Clinical value of capsule endoscopy for intestinal diseases in children","volume":"39","author":"Yang","year":"2022","journal-title":"Chin. J. Dig. Endosc."},{"key":"B31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3760\/cma.j.cn101785\u2014202206027\u2014002","article-title":"Application of digestive endoscopy in pediatric surgical diseases","volume":"21","author":"Zhao","year":"2022","journal-title":"J. Clin. Pediatr. Surg."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2025.1714118\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:34:40Z","timestamp":1768286080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2025.1714118\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":31,"alternative-id":["10.3389\/fphys.2025.1714118"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2025.1714118","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,13]]},"article-number":"1714118"}}