{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:55:08Z","timestamp":1793325308057,"version":"4.5.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960136"],"award-info":[{"award-number":["31960136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860167"],"award-info":[{"award-number":["81860167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460289"],"award-info":[{"award-number":["82460289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    The coexistence of osteoporosis and sarcopenia is recognized as a syndrome known as osteosarcopenia. As an aging-related disease, research into the molecular mechanisms of osteosarcopenia has gradually shifted from the study of single-organ pathology to the elucidation of multidimensional interactions. This review aims to construct a hierarchical framework of \u201cintracellular - intercellular - systemic\u201d to systematically elaborate on the pathogenesis of osteosarcopenia. Based on this foundation, it explores frontier interventions and their prospects for clinical transformation, including bone-targeting F6-(DSS)6-exo nanoparticles, miR-495, natural active compounds (resveratrol, nuciferine),\n                    <jats:italic>Clostridium<\/jats:italic>\n                    butyricum, and bimagrumab. Future research should focus on analyzing the microenvironment of the musculoskeletal interface, utilizing deep learning CT analysis for early risk identification, and exploring the application of biomaterials in osteomuscular regeneration. This review aims to provide a reference for the field of mechanism research in osteosarcopenia and offer new insights for its precision prevention and treatment.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2025.1723522","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:38:31Z","timestamp":1767940711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Osteosarcopenia: key molecular mechanisms and translational perspectives"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuan","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"123507","DOI":"10.1016\/j.lfs.2025.123507","article-title":"Aging-related hyperphosphatemia triggers the release of TNF-\u03b1 from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle","volume":"368","author":"Alcalde-Est\u00e9vez","year":"2025","journal-title":"Life Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1111\/andr.12774","article-title":"Testosterone replacement therapy","volume":"8","author":"Barbonetti","year":"2020","journal-title":"Andrology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e210080","DOI":"10.1148\/ryai.210080","article-title":"A fully automated deep learning pipeline for multi-vertebral level quantification and characterization of muscle and adipose tissue on chest CT scans","volume":"4","author":"Bridge","year":"2022","journal-title":"Radiol. 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