{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:01:08Z","timestamp":1775538068327,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12425208"],"award-info":[{"award-number":["12425208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272191"],"award-info":[{"award-number":["82272191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23H020007"],"award-info":[{"award-number":["LY23H020007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Left ventricular assist devices (LVADs) are widely used in advanced heart failure, but require accurate hemodynamic assessment for optimal management. Current invasive methods such as right-heart catheterisation (RHC) are limited in routine use, highlighting the need for non-invasive alternatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A non-invasive framework combining a lumped parameter model (LPM) with a hierarchical neural network (CLPM-Net) was developed to estimate patient-specific hemodynamic parameters from echocardiography and blood pressure. Model identifiability analysis was performed to select key parameters. The model was trained on synthetic data and validated with clinical cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proposed method achieved accurate parameter estimation with errors below 10% (RMSE). Simulated hemodynamic indicators showed strong agreement with ground truth (nMED &amp;lt; 1%). Clinical validation demonstrated close consistency with invasive measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This framework enables non-invasive, patient-specific hemodynamic assessment for LVAD management. It shows potential as an alternative to invasive monitoring, though further large-scale clinical validation is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1738196","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:15:49Z","timestamp":1775535349000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient-specific hemodynamic simulation for left ventricular assist device via non-invasive monitoring based on lumped parameter model and hierarchical neural network"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiayi","family":"Lyu","sequence":"first","affiliation":[{"name":"Transvascular Implantation Devices Research Institute","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Fluid Engineering, School of Aeronautics and Astronautics, Zhejiang University","place":["Hangzhou, Zhejiang, China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices, Zhejiang University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Fluid Engineering, School of Aeronautics and Astronautics, Zhejiang University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohua","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Transvascular Implantation Devices Research Institute","place":["Hangzhou, China"]},{"name":"Institute of Fluid Engineering, School of Aeronautics and Astronautics, Zhejiang University","place":["Hangzhou, Zhejiang, China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices, Zhejiang University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of cardiac surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangming","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of cardiac surgery, Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jcmg.2016.12.019","article-title":"3d morphological changes in lv and rv during lvad ramp studies","volume":"11","author":"Addetia","year":"2018","journal-title":"JACC Cardiovasc. 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