{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T22:14:01Z","timestamp":1787350441190,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study investigated the effects of high-intensity intermittent training (HIIT)\n                      <jats:italic>versus<\/jats:italic>\n                      moderate-intensity aerobic training (MAIT) on IL-27 signalling and adipose tissue browning in obese rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty male Sprague\u2013Dawley rats were randomly divided into two groups: standard diet (C, n = 10) and high-fat diet (HFD, n = 30). After 8 weeks of HFD feeding, 24 obese rats were further randomised into three subgroups: HFD (H, n = 8), HFD + moderate-intensity training (HMT, n = 8), and HFD + HIIT (HHT, n = 8). The HMT and HHT groups underwent 8 week training interventions (six sessions\/week). The HMT protocol included a 10 min warm-up (treadmill speed: 10 m\/min), a 40 min moderate-intensity aerobic phase (60%\u201370% of maximum speed), and a 10 min recovery (10 m\/min). The HHT protocol featured 10 min warm-up and recovery phases (10 m\/min), with 40 min of alternating treadmill training: 3 min at 50% maximum speed followed by 3 min at 90% maximum speed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences in body weight were observed between the HHT and HMT groups. HHT rats displayed significantly lower plasma triglyceride levels than H and HMT rats. Compared with HMT, HHT reduced adipose mass and adipocyte size and increased mitochondrial succinate dehydrogenase and cytochrome c oxidase (COX) activities in adipose tissue. However, HHT rats displayed lower COX activity in visceral white adipose tissue than HMT rats. Training upregulated browning-related genes and uncoupling protein 1 (UCP1) in adipose tissue, with stronger effects in HHT than in HMT. Plasma and adipose tissue IL-27 levels, as well as p38 MAPK\u2013PGC-1\u03b1 signalling pathway activation, were significantly elevated in both training groups, with greater increases in HHT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HIIT promotes adipose tissue browning by activating the IL-27 signalling pathway and ameliorates obesity-associated metabolic disorders more effectively than MAIT, supporting its potential as a therapeutic strategy for obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1745363","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:32:45Z","timestamp":1771997565000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-intensity intermittent training promotes adipose tissue browning via the IL-27\/p38 MAPK\u2013PGC-1\u03b1 signaling pathway in diet-induced obese rats"],"prefix":"10.3389","volume":"17","author":[{"given":"Chunlong","family":"Wang","sequence":"first","affiliation":[{"name":"College of Physical Education, Yangzhou University","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Sports Science","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/obr.12629","article-title":"Obesity as a risk factor for Alzheimer\u2019s disease: weighing the evidence","volume":"19","author":"Alford","year":"2018","journal-title":"Obes. 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