{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:39:12Z","timestamp":1773916752777,"version":"3.50.1"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>According to the recent data, imaging photoplethysmography has extensive capabilities in clinical and experimental biomedical research. However, relationship between local vasomotor reactions, estimated as fluctuations of the amplitude of pulsatile component (APC) of a photoplethysmographic waveform, and changes in systemic hemodynamic parameters remains unclear. The study aims to assess APC changes concurrently with changes in basic physiological parameters in response to administration of either vasodilating adenosine triphosphate or vasoconstrictor norepinephrine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In anesthetized, artificially ventilated rats (n=10), a video recording of the cerebral cortex was performed through thinned parietal bones synchronously with an electrocardiogram. Simultaneously, systemic blood pressure and end-tidal CO\n                      <jats:sub>2<\/jats:sub>\n                      were monitored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cerebrovascular effects of vasoactive agents are expressed in transient, pronounced and stereotypical changes in APC for all animals. For both substances, these changes are multiphasic, with at least two episodes of rise and fall in APC that do not correlate with changes in blood pressure. For the first time, opposite reaction vectors of intracranial and systemic hemodynamics were detected with the administration of either vasodilators and vasoconstrictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our study demonstrates that APC can be considered as a quantitative marker of local vasodilation\/vasoconstriction, which does not necessarily coincide with systemic hemodynamics, thus enabling an experimental investigation of autoregulation processes. The results obtained make it possible to link systemic and intracranial hemodynamic shifts caused by drugs into a single picture and clarify how adenosine triphosphate or norepinephrine affect the cardiovascular system and blood supply to the brain, which is very important due to the widespread use of these drugs in practical medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1777457","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:22:47Z","timestamp":1773897767000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging photoplethysmography reveals differences in the reactions of cerebral and systemic hemodynamics to infusion of vasoactive drugs"],"prefix":"10.3389","volume":"17","author":[{"given":"Alexey Y.","family":"Sokolov","sequence":"first","affiliation":[{"name":"Pavlov Institute of Physiology, Russian Academy of Sciences","place":["St. Petersburg, Russia"]},{"name":"Department of Neuropharmacology, Valdman Institute of Pharmacology, Pavlov First St. Petersburg State Medical University","place":["St. Petersburg, Russia"]},{"name":"Institute of Automation and Control Processes, Far Eastern Branch of the Russian Academy of Sciences","place":["Vladivostok, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriy V.","family":"Zaytsev","sequence":"additional","affiliation":[{"name":"Institute of Automation and Control Processes, Far Eastern Branch of the Russian Academy of Sciences","place":["Vladivostok, Russia"]},{"name":"North-Western District Scientific and Clinical Centre, Federal Medical and Biological Agency","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton V.","family":"Shcherbinin","sequence":"additional","affiliation":[{"name":"Institute of Automation and Control Processes, Far Eastern Branch of the Russian Academy of Sciences","place":["Vladivostok, Russia"]},{"name":"North-Western District Scientific and Clinical Centre, Federal Medical and Biological Agency","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei A.","family":"Kamshilin","sequence":"additional","affiliation":[{"name":"Institute of Automation and Control Processes, Far Eastern Branch of the Russian Academy of Sciences","place":["Vladivostok, Russia"]},{"name":"North-Western District Scientific and Clinical Centre, Federal Medical and Biological Agency","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1088\/0967-3334\/28\/3\/R01","article-title":"Photoplethysmography and its application in clinical physiological measurement","volume":"28","author":"Allen","year":"2007","journal-title":"Physiol. 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