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As a lysosome-dependent catabolic process induced by various cellular stress conditions, autophagy maintains the homeostasis of cells, tissues, and organs and is widely involved in different physiologic or pathologic processes in the tooth. Recently, accumulating studies have investigated the role of autophagy in OTM. In this review, we focus on the autophagy induced by orthodontic forces, discuss the multifaceted effects of autophagy in bone remodeling, inflammation, and complications in OTM, which may reveal the potential clinical implications of autophagy in OTM and provide potential therapeutic targets for future orthodontic clinical treatment.<\/jats:p>","DOI":"10.3389\/fphys.2026.1783943","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:02:15Z","timestamp":1774418535000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From mechanical force to cellular response: the role of autophagy in orthodontic tooth movement"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pathology, Shanxi Provincial People\u2019s Hospital, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanxi Provincial People\u2019s Hospital, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Hospital of Stomatology, Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongxiao","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanxi Provincial People\u2019s Hospital, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/edt.12382","article-title":"Which is the most recommended medium for the storage and transport of avulsed teeth? 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