{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:13:06Z","timestamp":1789582386567,"version":"build-2803163510"},"reference-count":134,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>Myopia is a complex ocular disorder arising from the interaction of genetic predisposition and environmental cues that regulate eye growth. Increasing evidence indicates that the circadian timing system plays a critical role in ocular development and refractive homeostasis. The retina, choroid, and sclera possess intrinsic molecular clocks that generate rhythmic oscillations in gene expression, neurotransmitter release, and tissue physiology. Disruption of these ocular circadian rhythms has been implicated in abnormal axial elongation through pathways involving dopamine and melatonin signaling, light-dependent retinal pathways, and diurnal fluctuations in intraocular pressure. In this review, we summarize current knowledge of the molecular mechanisms underlying circadian regulation in ocular tissues and discuss how environmental light exposure and sleep\u2013wake cycles modulate these processes. We further integrate evidence linking rhythmic alterations in retinal, choroidal, and scleral function to myopia development. Finally, we propose mechanistic frameworks through which circadian dysregulation may contribute to myopia onset and progression, highlighting potential molecular targets for rhythm-based intervention strategies.<\/jats:p>","DOI":"10.3389\/fphys.2026.1797489","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:22:40Z","timestamp":1775017360000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of circadian rhythms in the pathogenesis of myopia"],"prefix":"10.3389","volume":"17","author":[{"given":"Ning","family":"Zhang","sequence":"first","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University","place":["Tianjin, China"]},{"name":"Tianjin Key Lab of Ophthalmology and Vision Science, Tianjin Eye Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoge","family":"Han","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University","place":["Tianjin, China"]},{"name":"Tianjin Key Lab of Ophthalmology and Vision Science, Tianjin Eye Hospital","place":["Tianjin, China"]},{"name":"Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hao","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University","place":["Tianjin, China"]},{"name":"Tianjin Key Lab of Ophthalmology and Vision Science, Tianjin Eye Hospital","place":["Tianjin, China"]},{"name":"Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s42234-024-00159-0","article-title":"Blue light stimulation of the blind spot in human: from melanopsin to clinically relevant biomarkers of myopia","volume":"10","author":"Amorim-de-Sousa","year":"2024","journal-title":"Bioelectron. 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