{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:05:30Z","timestamp":1789362330709,"version":"build-2803163510"},"reference-count":138,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005922","name":"International Association for Dental Research","doi-asserted-by":"publisher","award":["2023-2025"],"award-info":[{"award-number":["2023-2025"]}],"id":[{"id":"10.13039\/100005922","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The traditional healthcare model, focused on symptom management, has shown limitations in addressing chronic diseases. In response, Bioregulatory Systems Medicine (BrSM) has emerged, an approach that promotes the body\u2019s self-regulation through multi-component drug and phytotherapeutic treatments. Its potential application in dentistry, particularly in periodontitis, has spurred the study of various natural molecules with the potential to prevent or reduce bone resorption. This qualitative systematic review analyzes the available evidence from animal and human models in the field of bioregulatory periodontal medicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A qualitative systematic review was conducted according to PRISMA-P guidelines. Animal and human studies published in English or Spanish within the last 10 years were included. The search was performed in five databases (SciELO, CENTRAL, PubMed, LILACS, and Web of Science) using MeSH terms. Data selection and analysis were performed in duplicate. Tools were applied to assess the risk of bias: SYRCLE for animal studies, Newcastle-Ottawa for observational studies, and RoB 2 for randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1,252 articles on calendula, caffeine, piperine, curcumin, and omega-3 fatty acids were found. Fifty-three studies were selected based on inclusion and exclusion criteria. Calendula and piperine reduced bone loss and inflammation in animal models. Curcumin and omega-3 fatty acids showed these effects in both animals and humans. For caffeine, the evidence was contradictory, although antibacterial activity was observed in experimental models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bioregulatory molecules decrease or prevent bone resorption caused by periodontitis, both in experimental animal studies and in clinical trials in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>System Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/osf.io\/<\/jats:ext-link>\n                      , identifier 3WHNA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1799419","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:37:05Z","timestamp":1789360625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?"],"prefix":"10.3389","volume":"17","author":[{"given":"Mar\u00eda Carolina","family":"Varas-Reyes","sequence":"first","affiliation":[{"name":"Conservative Dentistry Department, Faculty of Dentistry, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha Arelly","family":"Carrillo-\u00c1vila","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Yucat\u00e1n","place":["M\u00e9rida, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mart\u00ednez-Aguilar","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Yucat\u00e1n","place":["M\u00e9rida, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"\u00c1lvarez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Tissue Bioengineering Laboratory, Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n (DEPeI), Faculty of Dentistry, National Autonomous University of Mexico","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"D\u00edaz-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Atacama","place":["Copiap\u00f3, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samanta","family":"Melgar-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Conservative Dentistry Department, Faculty of Dentistry, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1186\/s12903-023-03512-y","article-title":"Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of patients with chronic periodontitis: a randomized controlled clinical trial","volume":"23","author":"Abdel-Fatah","year":"2023","journal-title":"BMC Oral. Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10831","DOI":"10.2147\/ijn.s524695","article-title":"Phytochemicals in bone therapy: Exploring natural alternatives for bone health","volume":"20","author":"Abdelnabi","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1024\/0300-9831\/a000243","article-title":"Effects of curcumin on alveolar bone loss in experimental periodontitis in rats: a morphometric and histopathologic study","volume":"87","author":"Akpinar","year":"2017","journal-title":"Int. J. Vitam Nutr. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1007\/s00784-017-2308-7","article-title":"Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats","volume":"22","author":"Alexandre","year":"2017","journal-title":"Clin. Oral. Investigations"},{"key":"B5","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1186\/s12912-025-03046-4","article-title":"Effectiveness of a continuous training program on knowledge and professional development of healthcare providers in healthy community clinics in Jordan: a quasi-experimental study","volume":"24","author":"Alsaqer","year":"2025","journal-title":"BMC Nurs."},{"key":"B6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/0970-9290.156806","article-title":"Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: a clinical and microbiological study","volume":"26","author":"Anitha","year":"2015","journal-title":"Indian J. Dent. Res."},{"key":"B7","first-page":"90","article-title":"Evaluation of anti-inflammatory effects of curcumin gel as an adjunct to scaling and root planing: a clinical study","volume":"7","author":"Anuradha","year":"2015","journal-title":"J. Int. Oral. Health"},{"key":"B8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4103\/0973-7847.120520","article-title":"A review on phytochemistry and ethnopharmacological aspects of genus Calendula","volume":"7","author":"Arora","year":"2013","journal-title":"Pharmacogn. Rev."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32566","article-title":"Curcumin-loaded scaffolds in bone regeneration","volume":"10","author":"Astaneh","year":"2024","journal-title":"Heliyon"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/app11010311","article-title":"A review of guidelines for antibiotic prophylaxis before invasive dental treatments","volume":"11","author":"Bakhsh","year":"2021","journal-title":"Appl. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1902\/jop.2016.150722","article-title":"Effect of curcumin on systemic T helper 17 cell response; gingival expressions of interleukin-17 and retinoic acid receptor-related orphan receptor \u03b3t; and alveolar bone loss in experimental periodontitis","volume":"87","author":"Bak\u0131r","year":"2016","journal-title":"J. Periodontol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"i6","DOI":"10.1093\/jac\/dky530","article-title":"Impact of antimicrobial therapy on the gut microbiome","volume":"74","author":"Bhalodi","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"B13","doi-asserted-by":"publisher","first-page":"Zc65","DOI":"10.7860\/jcdr\/2014\/8231.5343","article-title":"Novel therapeutic approach for the treatment of periodontitis by curcumin","volume":"8","author":"Bhatia","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-5-24","article-title":"JSME: a free molecule editor in JavaScript","volume":"5","author":"Bienfait","year":"2013","journal-title":"J. Cheminform"},{"key":"B15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.17113\/ftb.62.01.24.8175","article-title":"Identification of flavonoids, antioxidant and antiproliferative activity of aqueous infusions of Calendula officinalis L. Chelidonium majus L. Teucrium chamaedrys L. and Alchemilla vulgaris L","volume":"62","author":"Bilu\u0161i\u0107","year":"2024","journal-title":"Food. Technol. Bio\/Technol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/jper.20-0055","article-title":"Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17\/Treg imbalance","volume":"92","author":"Cafferata","year":"2021","journal-title":"J. Periodontol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s12603-014-0021-7","article-title":"Current evidence for the use of coffee and caffeine to prevent age-related cognitive decline and Alzheimer's disease","volume":"18","author":"Carman","year":"2014","journal-title":"J. nutrition Health Aging"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56060272","article-title":"Periodontitis, low-grade inflammation and systemic health: a scoping review","volume":"56","author":"Cecoro","year":"2020","journal-title":"Med. (Kaunas)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111662","article-title":"A comprehensive review of chemistry, sources and bioavailability of omega-3 fatty acids","volume":"10","author":"Cholewski","year":"2018","journal-title":"Nutrients"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108874","article-title":"Curcumin: overview of extraction methods, health benefits, and encapsulation and delivery using microemulsions and nanoemulsions","volume":"24","author":"Ciuca","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/beverages11010018","article-title":"Caffeinated beverages\u2014unveiling their impact on human health","volume":"11","author":"\u010ci\u017em\u00e1rov\u00e1","year":"2025","journal-title":"Beverages"},{"key":"B22","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/jre.12382","article-title":"Systemic treatment with resveratrol and\/or curcumin reduces the progression of experimental periodontitis in rats","volume":"52","author":"Corr\u00eaa","year":"2017","journal-title":"J. Periodontal Res."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14040371","article-title":"The impact of antibiotic therapy on intestinal microbiota: dysbiosis, antibiotic resistance, and restoration strategies","volume":"14","author":"Cusumano","year":"2025","journal-title":"Antibiotics (Basel)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5051\/jpis.2014.44.1.25","article-title":"Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial","volume":"44","author":"Deore","year":"2014","journal-title":"J. Periodontal Implant Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11017-010-9156-7","article-title":"Explanatory pluralism in the medical sciences: theory and practice","volume":"31","author":"De Vreese","year":"2010","journal-title":"Theor. Med. Bioeth"},{"key":"B26","first-page":"453","article-title":"The importance of maintaining a low omega-6\/omega-3 ratio for reducing the risk of autoimmune diseases, asthma, and allergies","volume":"118","author":"DiNicolantonio","year":"2021","journal-title":"Mo. Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.202100102","article-title":"The effects of omega\u20103 supplementation on serum oxidative stress parameters in experimental periodontitis in an animal model","volume":"123","author":"Do\u011fan","year":"2021","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/jre.12262","article-title":"Piperine inhibit inflammation, alveolar bone loss and collagen fibers breakdown in a rat periodontitis model","volume":"50","author":"Dong","year":"2015","journal-title":"J. Periodontal Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jebdp.2015.03.010","article-title":"Coffee consumption has no deleterious effects on periodontal health but its benefits are uncertain","volume":"15","author":"Duarte","year":"2015","journal-title":"J. Evid Based Dent. Pract."},{"key":"B30","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.4103\/0975-7406.191967","article-title":"Evaluation of superoxide dismutase levels in local drug delivery system containing 0.2% curcumin strip as an adjunct to scaling and root planing in chronic periodontitis: a clinical and biochemical study","volume":"8","author":"Elavarasu","year":"2016","journal-title":"J. Pharm. Bioallied Sci."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035677","article-title":"Antibiotic-induced changes in the human gut microbiota for the most commonly prescribed antibiotics in primary care in the UK: a systematic review","volume":"10","author":"Elvers","year":"2020","journal-title":"BMJ Open"},{"key":"B32","doi-asserted-by":"publisher","first-page":"6953","DOI":"10.1021\/acsomega.0c06198","article-title":"Solubility of piperine and its inclusion complexes in biorelevant media and their effect on attenuating mouse ileum contractions","volume":"6","author":"Ezawa","year":"2021","journal-title":"ACS Omega"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.sdentj.2024.09.014","article-title":"Comparative assessment of omega-3 and CoQ10 as adjuncts to periodontal therapy and total antioxidant capacity of saliva in patients with chronic periodontitis: a double-blind, randomized clinical trial","volume":"36","author":"Farahmand","year":"2024","journal-title":"Saudi Dent. J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.2337\/diabetes.51.4.1131","article-title":"Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study","volume":"51","author":"Festa","year":"2002","journal-title":"Diabetes"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.3889\/oamjms.2019.775","article-title":"Clinical applications of system regulation medicine","volume":"7","author":"Fioranelli","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032937","article-title":"Piperidine derivatives: Recent advances in synthesis and pharmacological applications","volume":"24","author":"Frolov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00225","article-title":"Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity","volume":"6","author":"Goldman","year":"2015","journal-title":"Front. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"6941","DOI":"10.1038\/s41467-025-62269-w","article-title":"Biosynthesis and bioactivity of anti-inflammatory triterpenoids in Calendula officinalis","volume":"16","author":"Golubova","year":"2025","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10266-023-00831-y","article-title":"A diet rich in omega-3 fatty acid improves periodontitis and tissue destruction by MMP2- and MMP9-linked inflammation in a murine model","volume":"112","author":"Gonz\u00e1lez-Alva","year":"2024","journal-title":"Odontology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1007\/s00784-018-2755-9","article-title":"Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats","volume":"23","author":"Guimaraes-Stabili","year":"2019","journal-title":"Clin. Oral. Investig."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immuno-microbial pathogenesis of periodontitis: Keystones, pathobionts, and the host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158845","article-title":"Association between consumption of coffee and the prevalence of periodontitis: The 2008-2010 Korea National Health and Nutrition Examination Survey","volume":"11","author":"Han","year":"2016","journal-title":"PloS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e785","DOI":"10.1016\/j.wneu.2018.03.081","article-title":"Effects of curcumin on bone loss and biochemical markers of bone turnover in patients with spinal cord injury","volume":"114","author":"Hatefi","year":"2018","journal-title":"World Neurosurg."},{"key":"B46","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3399\/bjgp19x702437","article-title":"Swimming upstream: practising whole-person medicine in a reductionist medical culture","volume":"69","author":"Hayward","year":"2019","journal-title":"Br. J. Gen. Pract."},{"key":"B47","article-title":"Cochrane handbook for systematic reviews of interventions version 6.5","volume-title":"Cochrane","author":"Higgins","year":"2024"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"326","DOI":"10.4103\/0974-8490.138287","article-title":"Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis","volume":"6","author":"Hosadurga","year":"2014","journal-title":"Pharmacognosy Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4103\/0976-9668.184701","article-title":"Influence of application of chlorhexidine gel and curcumin gel as an adjunct to scaling and root planing: a interventional study","volume":"7","author":"Hugar","year":"2016","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051332","article-title":"The antioxidant effect of curcumin and rutin on oxidative stress biomarkers in experimentally induced periodontitis in hyperglycemic Wistar rats","volume":"26","author":"Iova","year":"2021","journal-title":"Molecules"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.36295\/asro.2020.231226","article-title":"Effects of the systemic administration of omega -3 polyunsaturated fatty acid on experimental periodontitis: a histopathological study for rat\u2019s periodontal tissue","volume":"23","author":"Jalal","year":"2020","journal-title":"Ann. Trop. Med. Public Health"},{"key":"B54","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1111\/jcpe.12599","article-title":"Periodontal condition in relation to intake of omega-3 and omega-6 polyunsaturated fatty acids","volume":"43","author":"Jauhiainen","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-119","article-title":"A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation","volume":"6","author":"Jim\u00e9nez-Medina","year":"2006","journal-title":"BMC Cancer"},{"key":"B56","doi-asserted-by":"publisher","first-page":"505","DOI":"10.4103\/1735-3327.104866","article-title":"Systemic antibiotic therapy in periodontics","volume":"9","author":"Kapoor","year":"2012","journal-title":"Dent. Res. J. (Isfahan)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.100605","article-title":"Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway","volume":"47","author":"Ke","year":"2024","journal-title":"Biomed. J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/jre.12434","article-title":"Dietary supplementation with low-dose omega-3 fatty acids reduces salivary tumor necrosis factor-\u03b1 levels in patients with chronic periodontitis: a randomized controlled clinical study","volume":"52","author":"Keskiner","year":"2017","journal-title":"J. Periodontal Res."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/puh2.70116","article-title":"The role of mathematical modelling in predicting and controlling infectious disease outbreaks in underserved settings: a systematic review and meta-analysis","volume":"4","author":"Khumbudzo","year":"2025","journal-title":"Public Health Chall"},{"key":"B60","doi-asserted-by":"publisher","first-page":"111","DOI":"10.5483\/bmbrep.2016.49.2.128","article-title":"Caffeine inhibits adipogenesis through modulation of mitotic clonal expansion and the AKT\/GSK3 pathway in 3T3-L1 adipocytes","volume":"49","author":"Kim","year":"2016","journal-title":"BMB Rep."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1271\/bbb.69.2122","article-title":"Analysis of carotenoid composition in petals of calendula (Calendula officinalis L.)","volume":"69","author":"Kishimoto","year":"2005","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jep.2017.01.020","article-title":"Anti-inflammatory effect of the Salvia sclarea L. ethanolic extract on lipopolysaccharide-induced periodontitis in rats","volume":"199","author":"Kosti\u0107","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4103\/ijdr.ijdr_647_18","article-title":"Efficacy of omega 3 fatty acid as an adjunct in the management of chronic periodontitis: a randomized controlled trial","volume":"31","author":"Kujur","year":"2020","journal-title":"Indian J. Dent. Res."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd004625.pub5","article-title":"Routine scale and polish for periodontal health in adults","volume":"12","author":"Lamont","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12944-024-02159-0","article-title":"The association between polyunsaturated fatty acids and periodontitis: NHANES 2011-2014 and Mendelian randomisation analysis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00440","article-title":"The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis","volume":"8","author":"Lima","year":"2017","journal-title":"Front. Physiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"20720","DOI":"10.1038\/s41598-025-07916-4","article-title":"Caffeine intake is inversely associated with osteoporosis risk based on cross-sectional and genetic evidence","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1902\/jop.2005.76.11-S.2144","article-title":"Periodontal therapy reduces the rate of preterm low birth weight women with pregnancy-associates gingivitis","volume":"76","author":"L\u00f3pez","year":"2005","journal-title":"J. Periodontology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1902\/jop.2002.73.8.911","article-title":"Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial","volume":"73","author":"L\u00f3pez","year":"2002","journal-title":"J. Periodontology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.2147\/DDDT.S257494","article-title":"Potential impact of the multi-target drug approach in the treatment of some complex diseases","volume":"14","author":"Makhoba","year":"2020","journal-title":"Drug Des. Devel Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/s12903-022-02569-5","article-title":"Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in periodontitis patients: a randomized clinical trial","volume":"22","author":"Maybodi","year":"2022","journal-title":"BMC Oral. Health"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/ptr.4972","article-title":"Piper nigrum and piperine: an update","volume":"27","author":"Meghwal","year":"2013","journal-title":"Phytother. Res."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091939","article-title":"Vitamin C and omega-3 fatty acid intake is associated with human periodontitis-a nested case-control study","volume":"14","author":"Mewes","year":"2022","journal-title":"Nutrients"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.772418","article-title":"Anticancer applications and pharmacological properties of piperidine and piperine: a comprehensive review on molecular mechanisms and therapeutic perspectives","volume":"12","author":"Mitra","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47100827","article-title":"Beyond the cup: Coffee extracts as modulators of periodontal inflammation and bone remodeling","volume":"47","author":"Mody","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"8850926","DOI":"10.1155\/2020\/8850926","article-title":"Efficacy of curcumin gel on zinc, magnesium, copper, IL-1\u03b2, and TNF-\u03b1 in chronic periodontitis patients","volume":"2020","author":"Mohammad","year":"2020","journal-title":"BioMed. Res. Int."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11040521","article-title":"Effects of curcumin and tetracycline gel on experimental induced periodontitis as an anti-inflammatory, osteogenesis promoter and enhanced bone density through altered iron levels: histopathological study","volume":"11","author":"Mohammad","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1274189","article-title":"Effect of curcumin gel on inflammatory and anti-inflammatory biomarkers in experimental induced periodontitis in rats: a biochemical and immunological study","volume":"14","author":"Mohammad","year":"2023","journal-title":"Front. Microbiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"29566","DOI":"10.1038\/s41598-025-15165-8","article-title":"Curcumin preserves bone health compromised by diabetes by inhibiting osteoporosis through regulation of the SIRT3\/FoxO3a signalling pathway","volume":"15","author":"Mohammad","year":"2025","journal-title":"Sci. Rep."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2373040","DOI":"10.1080\/20002297.2024.2373040","article-title":"Curcumin inhibits growth of Porphyromonas gingivalis by arrest of bacterial dipeptidyl peptidase activity","volume":"16","author":"Murai","year":"2024","journal-title":"J. Oral. Microbiol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1055\/s-0042-1755448","article-title":"Evaluation of treatment with omega-3 fatty acid supplements on salivary levels of resolvin E1 in chronic periodontitis patients","volume":"13","author":"Murali","year":"","journal-title":"J. Health Allied Sci. NU"},{"key":"B82","doi-asserted-by":"publisher","first-page":"S554","DOI":"10.4103\/0975-7406.163537","article-title":"Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: a clinical and microbiological study","volume":"7","author":"Nagasri","year":"2015","journal-title":"J. Pharm. Bioallied Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1177\/0022034514541125","article-title":"Docosahexaenoic acid and periodontitis in adults: a randomized controlled trial","volume":"93","author":"Naqvi","year":"2014","journal-title":"J. Dent. Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Delivery"},{"key":"B85","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/pca.739","article-title":"Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester","volume":"15","author":"Neukirch","year":"2004","journal-title":"Phytochem. Anal."},{"key":"B86","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.chom.2019.10.011","article-title":"Recovery of the gut microbiota after antibiotics depends on host diet, community context, and environmental reservoirs","volume":"26","author":"Ng","year":"2019","journal-title":"Cell. Host Microbe"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1902\/jop.2013.130179","article-title":"Coffee consumption and periodontal disease in males","volume":"85","author":"Ng","year":"2014","journal-title":"J. Periodontol."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081685","article-title":"Isorhamnetin and quercetin derivatives as anti-acetylcholinesterase principles of marigold (Calendula officinalis) flowers and preparations","volume":"18","author":"Olennikov","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"298","DOI":"10.2334\/josnusd.19-0267","article-title":"Inhibitory effect of omega-3 fatty acids on alveolar bone resorption and osteoclast differentiation","volume":"62","author":"Ozaki","year":"2020","journal-title":"J. Oral. Sci."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.31222\/osf.io\/v7gm2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"B91","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/539426","article-title":"Health implications of high dietary omega-6 polyunsaturated fatty acids","volume":"2012","author":"Patterson","year":"2012","journal-title":"J. Nutr. Metab."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.2174\/0929867325666180927100120","article-title":"Omega-3 polyunsaturated fatty acid derived lipid mediators and their application in drug discovery","volume":"27","author":"Pazderka","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/os.12183","article-title":"Role of curcumin in common musculoskeletal disorders: a review of current laboratory, translational, and clinical data","volume":"7","author":"Peddada","year":"2015","journal-title":"Orthop. Surg."},{"key":"B95","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/jre.12683","article-title":"Impact of natural curcumin on the progression of experimental periodontitis in diabetic rats","volume":"55","author":"Pimentel","year":"2020","journal-title":"J. Periodontal Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.mjafi.2024.04.013","article-title":"Clinico-immunological evaluation of use of omega-3 fatty acids as nutraceutical approach in management of patients with chronic periodontitis: a randomized clinical trial","volume":"80","author":"Prasanth","year":"2024","journal-title":"Med. J. Armed Forces India"},{"key":"B97","doi-asserted-by":"publisher","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: from extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"B98","doi-asserted-by":"publisher","first-page":"197","DOI":"10.4103\/jisp.jisp_158_20","article-title":"Determination of efficacy of curcumin and Tulsi extracts as local drugs in periodontal pocket reduction: a clinical and microbiological study","volume":"25","author":"Rahalkar","year":"2021","journal-title":"J. Indian Soc Periodontol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"249","DOI":"10.4103\/jisp.jisp_528_18","article-title":"Comparison of effectiveness of low-dose aspirin versus omega-3 fatty acids as adjuvants to nonsurgical periodontal therapy in Type II diabetic patients with chronic periodontitis","volume":"23","author":"Rampally","year":"2019","journal-title":"J. Indian Soc Periodontol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.sdentj.2024.08.002","article-title":"The effect of curcumin 1% methanolic extract on the expression of matrix metalloproteinase-1, matrix metalloproteinase-8, matrix metalloproteinase-13, neutrophil, macrophage, lymphocyte counts in Porphyromonas gingivalis induced periodontitis: a randomized controlled trial","volume":"36","author":"Rani Safitri","year":"2024","journal-title":"Saudi Dental J."},{"key":"B101","doi-asserted-by":"publisher","first-page":"188","DOI":"10.4103\/jphi.jphi_82_17","article-title":"Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients","volume":"7","author":"Ravishankar","year":"2017","journal-title":"Int. J. Pharm. Investig."},{"key":"B102","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/19490976.2016.1216747","article-title":"Partial recovery of microbiomes after antibiotic treatment","volume":"7","author":"Raymond","year":"2016","journal-title":"Gut Microbes"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2024.100138","article-title":"Pharmacology of caffeine and its effects on the human body","volume":"10","author":"Reddy","year":"2024","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/s0027-9684(15)31505-4","article-title":"Patient centeredness, cultural competence and healthcare quality","volume":"100","author":"Saha","year":"2008","journal-title":"J. Natl. Med. Assoc."},{"key":"B105","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.sdentj.2023.03.007","article-title":"Inhibiting the growth of periopathogenic bacteria and accelerating bone repair processes by using robusta coffee bean extract","volume":"35","author":"Sari","year":"2023","journal-title":"Saudi Dent. J."},{"key":"B106","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00784-024-05835-8","article-title":"Clinical effects of omega-3 fatty acids supplementation in the periodontal treatment of smokers and non-smokers with periodontitis: a retrospective study","volume":"28","author":"Savran","year":"2024","journal-title":"Clin. Oral. Investig."},{"key":"B107","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.jds.2020.09.015","article-title":"Effects of curcumin gel on osteoclastogenic bone markers in experimental periodontitis and alveolar bone loss in wistar rats","volume":"16","author":"Sha","year":"2021","journal-title":"J. Dent. Sci."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040611","article-title":"An updated review on the multifaceted therapeutic potential of Calendula officinalis L","volume":"16","author":"Shahane","year":"2023","journal-title":"Pharm. (Basel)"},{"key":"B109","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 polyunsaturated fatty acids and their health benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01021","article-title":"Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications","volume":"11","author":"Sharifi-Rad","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmic.2025.100122","article-title":"Impact of macrolide antibiotics on gut microbiota diversity with age-specific implications and scientific insights","volume":"24","author":"Shayista","year":"2025","journal-title":"Med. Microecol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"415","DOI":"10.22074\/cellj.2017.4364","article-title":"Caffeine augments the instruction of anti-inflammatory macrophages by the conditioned medium of mesenchymal stem cells","volume":"19","author":"Shushtari","year":"2017","journal-title":"Cell. J."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8020031","article-title":"Anti-inflammatory activity of Calendula officinalis L. flower extract","volume":"8","author":"Silva","year":"2021","journal-title":"Cosmetics"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.21767\/2254-9137.100064","article-title":"A systematic review of physician retirement planning","volume":"14","author":"Silver","year":"2016","journal-title":"Hum. Resour. Health"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092614","article-title":"Omega-3 polyunsaturated fatty acids EPA and DHA as an adjunct to non-surgical treatment of periodontitis: a randomized clinical trial","volume":"12","author":"Sta\u0144do","year":"2020","journal-title":"Nutrients"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03018-7","article-title":"Clinical and microbiological outcomes of subgingival instrumentation supplemented with high-dose omega-3 polyunsaturated fatty acids in periodontal treatment - a randomized clinical trial","volume":"23","author":"Sta\u0144do-Retecka","year":"2023","journal-title":"BMC Oral. Health"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"Bmj"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1007\/s00784-021-04208-9","article-title":"The association between coffee consumption and periodontitis: a cross-sectional study of a northern German population","volume":"26","author":"Struppek","year":"2022","journal-title":"Clin. Oral. Investig."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx250","article-title":"Use of antibiotic prophylaxis for tooth extractions, dental implants, and periodontal surgical procedures","volume":"5","author":"Suda","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"314","DOI":"10.30476\/DENTJODS.2020.83660.1056","article-title":"Effects of Calendula officinalis and Hypericum perforatum on antioxidant, anti-inflammatory, and histopathology indices of induced periodontitis in male rats","volume":"21","author":"Tanideh","year":"2020","journal-title":"J. Dent. (Shiraz)"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00327","article-title":"Periodontitis and Alzheimer's disease: a possible comorbidity between oral chronic inflammatory condition and neuroinflammation","volume":"9","author":"Teixeira","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1111\/jcpe.12089","article-title":"Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","author":"Tonetti","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s10266-019-00432-8","article-title":"Curcumin inhibits the expression of proinflammatory mediators and MMP-9 in gingival epithelial cells stimulated for a prolonged period with lipopolysaccharides derived from Porphyromonas gingivalis","volume":"108","author":"Toraya","year":"2020","journal-title":"Odontology"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092235","article-title":"Potential oral health care agent from coffee against virulence factor of periodontitis","volume":"11","author":"Tsou","year":"2019","journal-title":"Nutrients"},{"key":"B125","doi-asserted-by":"publisher","first-page":"386","DOI":"10.4103\/jisp.jisp_16_16","article-title":"Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1\u03b2 levels in patients with chronic periodontitis: a clinico-immunological study","volume":"21","author":"Umrania","year":"2017","journal-title":"J. Indian Soc Periodontol."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11020135","article-title":"Curcumin: biological activities and modern pharmaceutical forms","volume":"11","author":"Uro\u0161evi\u0107","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"B127","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3109\/0886022x.2015.1103585","article-title":"Total antioxidant and oxidant status of plasma and renal tissue of cisplatin-induced nephrotoxic rats: protection by floral extracts of Calendula officinalis Linn","volume":"38","author":"Verma","year":"2016","journal-title":"Ren Fail."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1136\/bmj.329.7479.1398","article-title":"Do biomedical models of illness make for good healthcare systems","volume":"329","author":"Wade","year":"2004","journal-title":"Bmj"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1446536","article-title":"The potential therapeutic role of curcumin in osteoporosis treatment: based on multiple signaling pathways","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24129835","article-title":"Curcumin attenuates periodontal injury via inhibiting ferroptosis of ligature-induced periodontitis in mice","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"21063","DOI":"10.1038\/s41598-024-71426-y","article-title":"Association between coffee and tea consumption and the risk of dementia in individuals with hypertension: a prospective cohort study","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9578","article-title":"Neuroprotective and neurodegenerative aspects of coffee and its active ingredients in view of scientific literature","volume":"12","author":"Wasim","year":"2020","journal-title":"Cureus"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2025.1578484","article-title":"A retrospective study on the impact of different antibiotic regimens in non-surgical periodontal therapy on microbial loads and therapy outcomes","volume":"6","author":"Werner","year":"2025","journal-title":"Front. Oral. Health"},{"key":"B134","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13005-018-0169-1","article-title":"Protective effect and related mechanisms of curcumin in rat experimental periodontitis","volume":"14","author":"Xiao","year":"2018","journal-title":"Head Face Med."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27123737","article-title":"Neuroprotective effect of caffeine in Alzheimer's disease","volume":"27","author":"Yelanchezian","year":"2022","journal-title":"Molecules"},{"key":"B136","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.tiv.2008.12.021","article-title":"Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts","volume":"23","author":"Zdarilov\u00e1","year":"2009","journal-title":"Toxicol. Vitro"},{"key":"B137","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/cre2.162","article-title":"Systemic inflammatory burden and local inflammation in periodontitis: What is the link between inflammatory biomarkers in serum and gingival crevicular fluid","volume":"5","author":"Zekeridou","year":"2019","journal-title":"Clin. Exp. Dent. Res."},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111469","article-title":"Curcumin's beneficial effects on neuroblastoma: mechanisms, challenges, and potential solutions","volume":"10","author":"Zhai","year":"2020","journal-title":"Biomolecules"}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1799419\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:37:18Z","timestamp":1789360638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1799419\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":138,"alternative-id":["10.3389\/fphys.2026.1799419"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2026.1799419","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"article-number":"1799419"}}