{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:11:52Z","timestamp":1779095512153,"version":"3.51.4"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008688","name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["A1-S-9082"],"award-info":[{"award-number":["A1-S-9082"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Aldosterone (Aldo), a mineralocorticoid hormone, modulates cardiovascular function by regulating the expression of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    handling proteins, among other effects. In rat resistance-sized mesenteric arteries (MA), Aldo treatment (10 nM, 24\u00a0h) upregulates both the L-type voltage-gated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel \u03b1\n                    <jats:sub>1C<\/jats:sub>\n                    subunit (Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2) and the Sarco\/Endoplasmic Reticulum Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ATPase (SERCA pump), thereby increasing Sarcoplasmic Reticulum (SR) Ca\n                    <jats:sup>2+<\/jats:sup>\n                    load. Two SERCA isoforms, SERCA2a and SERCA2b, are expressed in rat MA, but their specific physiological contributions to distinct intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals, remain unclear. In this study, we characterized the relative abundance and subcellular distribution of SERCA2a and SERCA2b in rat MA, their regulation by Aldo, and the impact of Aldo-induced SERCA remodeling on local Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals relevant to vascular function, such as Ca\n                    <jats:sup>2+<\/jats:sup>\n                    sparks and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    waves. Aldo-treated MA smooth muscle cells (MASMC) exhibited increased Ca\n                    <jats:sup>2+<\/jats:sup>\n                    spark frequency and a higher incidence of spontaneous Ca\n                    <jats:sup>2+<\/jats:sup>\n                    waves. Aldo augmented both protein and mRNA levels of SERCA2a and SERCA2b, effects that were blocked by the mineralocorticoid receptor (MR) antagonist RU28318. Under control conditions, SERCA2a was predominantly localized in the perinuclear region, whereas SERCA2b was distributed across both subplasmalemmal and perinuclear regions. Aldo treatment increased the expression of both isoforms in all analyzed subcellular compartments (subplasmalemmal, cytoplasmic, and perinuclear), with a pronounced redistribution towards the subplasmalemmal region of MASMC. This shift in SERCA subcellular distribution likely contributes to enhanced superficial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    buffering and the ignition of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    sparks and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    waves. Furthermore, Aldo increased mRNA levels of mitochondrial transcription factors A and B2 (TFAM and TFB2M), previously implicated in SERCA regulation in human aorta, suggesting a transcriptional mechanism whereby MR activation of the SERCA2 gene is associated with increased TFAM and TFB2M expression. Collectively, these findings demonstrate for the first time that Aldo increases the expression and promotes the subplasmalemmal localization of SERCA2a and SERCA2b in MASMC. This remodeling underscores their critical role in maintaining the superficial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    buffering system and SR Ca\n                    <jats:sup>2+<\/jats:sup>\n                    load to prevent pathological elevations in the intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    concentration. Our results highlight the SERCA pump as a potential therapeutic target in hypertension associated with hyperaldosteronism.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1811001","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:25:32Z","timestamp":1777868732000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Aldosterone increases the expression and subcellular localization of SERCA2a and SERCA2b in the rat mesenteric artery"],"prefix":"10.3389","volume":"17","author":[{"given":"Cristian J.","family":"Arriero-Carrillo","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiram","family":"Lozano-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Guerrero-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Castro-Mu\u00f1ozledo","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Rueda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center for Research and Advanced Studies (Cinvestav) of the National Polytechnic Institute","place":["Mexico City, Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/micc.12046","article-title":"Calcium dynamics in vascular smooth muscle","volume":"20","author":"Amberg","year":"2013","journal-title":"Microcirculation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/09687860500412257","article-title":"Thyroid hormones differentially regulate the distribution of rabbit skeletal muscle Ca2+-ATPase (SERCA) isoforms in light and heavy sarcoplasmic reticulum","volume":"22","author":"Arruda","year":"2005","journal-title":"Mol. 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