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Recent studies indicate that metabolic reprogramming significantly influences fibroblast activation, collagen deposition, and the fibrotic process by reshaping glycolytic, lipid, and amino acid metabolic pathways. This paper systematically reviews the mechanism of metabolic reprogramming in cardiac fibrosis and puts forward potential intervention strategies from a critical perspective. Although metabolic reprogramming shows potential in regulating cardiac fibrosis, its practical application still faces major challenges. Future research should strive to build a comprehensive research framework and promote metabolic reprogramming research to open a new way of precise intervention for the prevention and treatment of cardiac fibrosis through cross\u2212technological innovation and precise regulation.<\/jats:p>","DOI":"10.3389\/fphys.2026.1811882","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:26:04Z","timestamp":1785126364000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaoqian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Yanbian University (Yanbian Hospital), Yanbian University","place":["Yanji, China"]},{"name":"College of Pharmacy, Yanbian University","place":["Yanji, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Yanbian University (Yanbian Hospital), Yanbian University","place":["Yanji, China"]},{"name":"College of Pharmacy, Yanbian University","place":["Yanji, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Yanbian University (Yanbian Hospital), Yanbian University","place":["Yanji, China"]},{"name":"College of Pharmacy, Yanbian University","place":["Yanji, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ding","sequence":"additional","affiliation":[{"name":"Shanghai Fourth People's Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghua","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Yanbian University (Yanbian Hospital), Yanbian University","place":["Yanji, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165739","article-title":"Cardiac ketone body metabolism","volume":"1866","author":"Abdul Kadir","year":"2020","journal-title":"Biochim. 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