{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:08:03Z","timestamp":1779253683500,"version":"3.51.4"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Studies have revealed circadian rhythms affect many organ systems and time of injury can impact healing, lung function, and inflammation. We hypothesized operative time may impact post-operative risk. Accordingly, the aim of this study was to compare post-operative complications in patients whose surgery started and finished before 12pm (Group 1); after 12pm (Group 2); and started before 12pm and finished after 12pm (Group 3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients from two previous prospective studies were included in this\n                      <jats:italic>post-hoc<\/jats:italic>\n                      analysis. Inclusion criteria were indication for lung resection surgery (confirmed or highly suspicious tumor), age \u226518 and ability to undergo cardiopulmonary exercise testing (CPET). Exclusion criterion was inability to perform surgery (either low predicted postoperative oxygen consumption or inoperability). All patients underwent pre-operative CPET and spirometry. Post-operative pulmonary (PPC) and cardiovascular complications (PCC) were prospectively assessed from the hospital stay up to 30 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 497 patients were analyzed. On comparison of groups, there were differences in BMI (highest in Group 3), surgery duration (lowest in Group 1) and frequency of lobectomies (lowest in Group 1). Incidence of PPC was lowest in Group 1 (n=17; 9%) compared to n=17 (21%) in Group 2 and n=37 (17%) in Group 3 (p=0.01). Incidence of PCC was lowest in Group 1 n=25 (13%) compared to n=19 (23%) in Group 2 and n=46 (21%) in Group 3 (p=0.05). Multivariate logistic regression adjusted for confounders (BMI, surgery duration and lobectomy) showed time of surgery after 12pm was independently associated with PPC with OR\u00a0=\u00a02.17 (95% CI 1.07-4.41); p=0.03.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Time of surgery may impact the incidence of PPC in lung resection surgery patients with highest risk in patients undergoing the surgery after 12pm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1818583","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:33:05Z","timestamp":1779251585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Circadian variation of post-operative complications in lung resection surgery"],"prefix":"10.3389","volume":"17","author":[{"given":"Marek","family":"Lukes","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Masaryk University","place":["Brno, Czechia"]},{"name":"Centre of Cardiovascular and Transplant Surgery","place":["Brno, Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Brat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University","place":["Brno, Czechia"]},{"name":"Center for Pulmonology and Interventional Bronchology, Masaryk Memorial Cancer Institute","place":["Brno, Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hruda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University","place":["Brno, Czechia"]},{"name":"Department of Anesthesiology and Intensive Care, St. Anne\u2019s University Hospital Brno","place":["Brno, Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zden\u011bk","family":"Chovanec","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University","place":["Brno, Czechia"]},{"name":"First Department of Surgery, St. Anne\u2019s University Hospital","place":["Brno, Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University","place":["Brno, Czechia"]},{"name":"Institute of Biostatistics and Analyses, Ltd.","place":["Brno, Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic","place":["Rochester, MN, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Ivan","family":"Cundrle","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University","place":["Brno, Czechia"]},{"name":"Department of Anesthesiology and Intensive Care, St. Anne\u2019s University Hospital Brno","place":["Brno, Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1056\/NEJMra1802337","article-title":"Circadian mechanisms in medicine","volume":"384","author":"Allada","year":"2021","journal-title":"N. 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