{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:42Z","timestamp":1786429662864,"version":"build-2736575974"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:p>\n                    Among potential molecular mechanisms supporting cardiovascular homeostasis, miRNAs (miRs) represent interesting candidates. We recently highlighted that miR-199a controls the Nitric oxide synthase\/nitric oxide (NOS\/NO) pathway in the endothelium and showed that both mature strands of miR-199a are overexpressed in heart and vessels from a mouse model of hypertension. Here we investigated the fate of miR-199a in heart and vessels from mice developing physiological or pathological cardiac hypertrophy. Our working hypothesis is that alterations in cell phenotypes driven by changes in miR-199a abundance account for cardiac and\/or vascular adaptation to increased workload in patho-physiological contexts. C57BL\/6J mice were given access to voluntary dynamic wheel training during 22 weeks or underwent transverse aortic constriction (TAC) surgery. As a result, those mice respectively developed physiological and pathological cardiac hypertrophy. An opposite modulation of miR-199a-3p and miR-199a-5p expression was observed in vessels and heart from running\n                    <jats:italic>vs<\/jats:italic>\n                    TAC mice which correlated with opposite regulation of Retinobastoma1 (RB1) in cardiac tissue. We show that miR-199a-3p upregulation, by indirectly modulating CCAAT\/enhancer binding protein (C\/EBP)\u03b2, promotes cardiomyocyte hypertrophy in the pathological settings, while its repression by exercise drives metabolic adaptations associated with physiological remodeling. Interestingly, miR-199a-5p repression also directly target Sirtuin 1 (Sirt-1) and Peroxisome proliferator-activated receptor coactivator (PGC1)\u03b1 Taken together, our findings indicate that both mature arms of miR-199a act in tandem to drive morphologic and metabolic adaptations encountered in physiological and pathological cardiac hypertrophy.\n                  <\/jats:p>","DOI":"10.3389\/fphys.2026.1833828","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:34:45Z","timestamp":1786426485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR-199a family members are differentially regulated during physiological and pathological cardiac hypertrophy"],"prefix":"10.3389","volume":"17","author":[{"given":"Virginie","family":"Joris","sequence":"first","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Marchand","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Metzinger","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Dumas","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrag","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Feron","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Horman","sequence":"additional","affiliation":[{"name":"Pole of Cardiovascular Research (CARD), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Dessy","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology and Therapeutics (FATH), Experimental and Clinical Research Institute (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1172\/JCI9056","article-title":"Deactivation of peroxisome proliferator\u2013activated receptor-\u03b1 during cardiac hypertrophic growth","volume":"105","author":"Barger","year":"2000","journal-title":"J. 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