{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:03:42Z","timestamp":1790053422174,"version":"4.0.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic heart failure (CHF) is frequently comorbid with depression and anxiety. Currently, we aim to investigate the association between serum adiponectin levels and depression among patients with CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 119 patients with HF in a tertiary hospital in southern China were enrolled. All patients completed the Patient Health Questionnaire-9 (PHQ-9) upon discharge. Serum levels of adiponectin, ghrelin, leptin A, and BDNF were measured. On the basis of PHQ-9 scores, HF patients were divided into non-Dep, mild-Dep, moderate-Dep, and severe-Dep groups. Differences in the levels of cardiac markers and serum mediators between the non\/mild-Dep group and the moderate\/severe-Dep group were analyzed using weighted univariate and multivariate logistic regression models. An HF C57BL\/6 mouse model of depression was established. AdipoRon, an orally active adiponectin receptor agonist, was administered to the mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 119 patients with CHF were categorized into non-Dep (n=35), mild-Dep (n=46), moderate-Dep (n=20), and severe-Dep groups (n=18). Compared with those in the non-Dep group, adiponectin levels in the Dep group were significantly lower and correlated with increased depression severity in HF patients. Weighted univariate and multivariate regression analyses indicated that adiponectin (OR\u00a0=\u00a00.719; 95% CI: 0.531\u20130.975) and exercise duration (OR\u00a0=\u00a00.655; 95% CI: 0.489\u20130.877) were potential predictors of CHF comorbid with depression. Spearman correlation analysis revealed a positive correlation between adiponectin levels and exercise frequency\/duration, whereas negative correlations were found between depression scores and exercise frequency\/duration. Sensitivity analyses with stepwise exclusion of high-risk subgroups (diabetes, systemic inflammation, and severe HF) revealed a significant association between exercise duration and depression. In a depression model in MI mice, serum adiponectin levels were decreased. Compared with single-treatment approaches, the combination of adiponectin receptor agonists and exercise intervention effectively improved depressive-like behaviors in mice and regulated related biomarker levels, with superior effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Reduced serum adiponectin levels and exercise activity were associated with increased odds of having CHF comorbid with depression. Activation of the adiponectin\/AdipoR1 pathway combined with exercise intervention has potential benefits for the prevention of depression in patients with HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1835186","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:22:15Z","timestamp":1790050935000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced serum adiponectin and exercise predict depression in chronic heart failure patients and affect depressive-like behaviors in a mouse model"],"prefix":"10.3389","volume":"17","author":[{"given":"Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guangzhou Red Cross Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou Red Cross Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou Red Cross Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou Red Cross Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neures.2023.02.001","article-title":"Astrocytes and brain-derived neurotrophic factor (BDNF)","volume":"197","author":"Albini","year":"2023","journal-title":"Neurosci. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/eurjhf\/hfp046","article-title":"Adiponectin is increased in cardiac cachexia irrespective of body mass index","volume":"11","author":"Ara\u00fajo","year":"2009","journal-title":"Eur. J. Heart Fail."},{"key":"B3","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41398-024-03135-z","article-title":"Basolateral amygdala parvalbumin and cholecystokinin-expressing GABAergic neurons modulate depressive and anxiety-like behaviors","volume":"14","author":"Asim","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13979","article-title":"Complexity analysis from EEG data in congestive heart failure: A study via approximate entropy","volume":"238","author":"Cacciotti","year":"2023","journal-title":"Acta Physiol. (Oxf)."},{"key":"B5","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public Health Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.ijcard.2009.03.006","article-title":"Elevated adiponectin levels in patients with chronic heart failure: an independent predictor of mortality or a marker of cardiac cachexia","volume":"144","author":"Celik","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"45021","DOI":"10.1074\/jbc.m307878200","article-title":"Adiponectin stimulates production of nitric oxide in vascular endothelial cells","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.4088\/jcp.09m05314blu","article-title":"Low 24-hour adiponectin and high nocturnal leptin concentrations in a case-control study of community-dwelling premenopausal women with major depressive disorder: the Premenopausal, Osteopenia\/Osteoporosis, Women, Alendronate, Depression (POWER) study","volume":"71","author":"Cizza","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jchf.2022.07.007","article-title":"Risks of depression and suicide after diagnosis with heart failure: A national cohort study","volume":"10","author":"Crump","year":"2022","journal-title":"JACC Heart Fail."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/j.jacc.2019.01.072","article-title":"Exercise intolerance in patients with heart failure: JACC state-of-the-art review","volume":"73","author":"Del Buono","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.jpsychires.2012.04.028","article-title":"Reduced serum levels of adiponectin in elderly patients with major depression","volume":"46","author":"Diniz","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/ijnp\/pyx024","article-title":"Effect of physical exercise and acute escitalopram on the excitability of brain monoamine neurons: In vivo electrophysiological study in rats","volume":"20","author":"Dremencov","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/ejn.14547","article-title":"Neurobiology of resilience in depression: immune and vascular insights from human and animal studies","volume":"53","author":"Dudek","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.1523\/jneurosci.23-19-07311.2003","article-title":"The role of the extracellular signal-regulated kinase signaling pathway in mood modulation","volume":"23","author":"Einat","year":"2003","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1007\/s00221-022-06446-z","article-title":"CaMKIV\/CREB\/BDNF signaling pathway expression in prefrontal cortex, amygdala, hippocampus and hypothalamus in streptozotocin-induced diabetic mice with anxious-like behavior","volume":"240","author":"Espasand\u00edn","year":"2022","journal-title":"Exp. Brain Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1016\/j.jacc.2022.02.050","article-title":"Venous tone and stressed blood volume in heart failure: JACC review topic of the week","volume":"79","author":"Fudim","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/endrev\/bnae021","article-title":"Adiponectin and adiponectin receptors in atherosclerosis","volume":"46","author":"Gianopoulos","year":"2025","journal-title":"Endocr. Rev."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910804","article-title":"Adiponectin and inflammatory marker levels in the elderly patients with diabetes, mild cognitive impairment and depressive symptoms","volume":"25","author":"Gorska-Ciebiada","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1093\/jalm\/jfac069","article-title":"Comparison of high-sensitivity C-reactive protein vs C-reactive protein for cardiovascular risk prediction in chronic cardiac disease","volume":"7","author":"Han","year":"2022","journal-title":"J. Appl. Lab. Med."},{"key":"B20","first-page":"146","article-title":"Reduction in oxidative stress and modulation of heart failure subsequent to myocardial infarction in rats","volume":"10","author":"Hill","year":"2005","journal-title":"Exp. Clin. Cardiol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15272","article-title":"Diabetic complications and risk of depression and anxiety among adults with type 2 diabetes","volume":"41","author":"Horsb\u00f8l","year":"2024","journal-title":"Diabetes Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.brainres.2008.12.012","article-title":"Adiponectin acts in the nucleus of the solitary tract to decrease blood pressure by modulating the excitability of neuropeptide Y neurons","volume":"1256","author":"Hoyda","year":"2009","journal-title":"Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"G187","DOI":"10.1152\/ajpgi.00203.2023","article-title":"Adiponectin affects ileal contractility of mouse preparations","volume":"326","author":"Idrizaj","year":"2024","journal-title":"Am. J. Physiol. Gastrointest Liver. Physiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.psyneuen.2011.11.002","article-title":"Plasma adiponectin elevation in elderly individuals with subsyndromal depression","volume":"37","author":"Jeong","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"15669","DOI":"10.1523\/jneurosci.2588-13.2013","article-title":"Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses","volume":"33","author":"Kallarackal","year":"2013","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jad.2025.05.016","article-title":"Psychological distress and myocardial infarction (MI): A cross-sectional and longitudinal UK population-based study","volume":"384","author":"Kang","year":"2025","journal-title":"J. Affect. Disord."},{"key":"B27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11892-025-01610-5","article-title":"The cardioprotective effects of adiponectin in diabetes","volume":"25","author":"Kazemi","year":"2025","journal-title":"Curr. Diabetes Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta22630","article-title":"Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT","volume":"22","author":"Kessler","year":"2018","journal-title":"Health Technol. Assess."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1038\/s41380-024-02464-1","article-title":"Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1\/M2 polarization through adiponectin\/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress","volume":"29","author":"Liu","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2217\/fca-2020-0095","article-title":"Adiponectin in heart failure","volume":"17","author":"Mado","year":"2021","journal-title":"Future Cardiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"904","DOI":"10.2174\/1570159x21666230811141557","article-title":"The HPA axis as target for depression","volume":"22","author":"Menke","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.bbi.2016.03.012","article-title":"Depression and markers of inflammation as predictors of all-cause mortality in heart failure","volume":"57","author":"Mommersteeg","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2021.100848","article-title":"Global prevalence of depression among heart failure patients: A systematic review and meta-analysis","volume":"47","author":"Moradi","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4950","DOI":"10.1111\/dom.16542\/v2\/response1","article-title":"AdipoRon attenuates steatosis, inflammation and fibrosis in murine diet-induced NASH via inhibiting ER stress","volume":"27","author":"Nie","year":"2025","journal-title":"Diabetes Obes. Metab."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1056\/NEJMoa072761","article-title":"Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes","volume":"356","author":"Nissen","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.tem.2014.03.009","article-title":"Role of anti-inflammatory adipokines in obesity-related diseases","volume":"25","author":"Ohashi","year":"2014","journal-title":"Trends Endocrinol. Metabolism.: TEM."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026865","article-title":"Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model","volume":"6","author":"Palus","year":"2011","journal-title":"PloS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.hfc.2021.01.007","article-title":"Exercise-based cardiac rehabilitation programs in heart failure patients","volume":"17","author":"Patti","year":"2021","journal-title":"Heart Fail. Clin."},{"key":"B39","doi-asserted-by":"publisher","first-page":"H1050","DOI":"10.1152\/ajpheart.00943.2011","article-title":"Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance","volume":"302","author":"Poole","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"542","DOI":"10.4103\/0366-6999.200536","article-title":"Association between N-terminal proB-type natriuretic peptide and depressive symptoms in patients with acute myocardial infarction","volume":"130","author":"Ren","year":"2017","journal-title":"Chin. Med. J. (Engl)."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.jacc.2006.06.055","article-title":"Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes","volume":"48","author":"Rutledge","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","article-title":"A novel serum protein similar to C1q, produced exclusively in adipocytes","volume":"270","author":"Scherer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1038\/s41598-018-38201-2","article-title":"Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals","volume":"9","author":"Sch\u00f6n","year":"2019","journal-title":"Sci. Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1002\/ehf2.15326","article-title":"Association between NT-proBNP changes and clinical outcomes in paediatric patients with heart failure: Insights from PANORAMA-HF and PARADIGM-HF","volume":"12","author":"Shaddy","year":"2025","journal-title":"ESC. Heart Fail."},{"key":"B46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jjcc.2013.11.003","article-title":"Risk factors for onset of depression after heart failure hospitalization","volume":"64","author":"Shimizu","year":"2014","journal-title":"J. Cardiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/psy.0b013e31820ad12b","article-title":"Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research","volume":"73","author":"Stetler","year":"2011","journal-title":"Psychosom. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1161\/CIRCRESAHA.125.325531","article-title":"Cardiovascular aging and exercise: Implications for heart failure prevention and management","volume":"137","author":"Subramanian","year":"2025","journal-title":"Circ. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"390","DOI":"10.33549\/physiolres.931623","article-title":"Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats","volume":"232","author":"Tanida","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)."},{"key":"B50","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: A review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.tics.2013.08.001","article-title":"Bridging animal and human models of exercise-induced brain plasticity","volume":"17","author":"Voss","year":"2013","journal-title":"Trends Cognit. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.genhosppsych.2014.05.021","article-title":"Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population","volume":"36","author":"Wang","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1002\/ehf2.15208","article-title":"Frailty determinants in heart failure: Inflammatory markers, cognitive impairment and psychosocial interaction","volume":"12","author":"Wleklik","year":"2025","journal-title":"ESC. Heart Fail."},{"key":"B54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00395-022-00956-1","article-title":"Bone marrow-derived na\u00efve B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozin","volume":"117","author":"Xu","year":"2022","journal-title":"Basic. Res. Cardiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.057","article-title":"Reduced serum adiponectin level and risk of poststroke depression in patients with ischemic stroke","volume":"28","author":"Yang","year":"2019","journal-title":"J. Stroke. Cerebrovasc. Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1177\/1099800419894641","article-title":"Positive association between serum levels of high-sensitivity C-reactive protein and depression\/anxiety in female, but not male, patients with type 2 diabetes mellitus","volume":"22","author":"Yang","year":"2020","journal-title":"Biol. Res. Nurs."},{"key":"B57","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.chmed.2022.06.012","article-title":"New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway","volume":"15","author":"Yang","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1038\/mp.2016.58","article-title":"Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors","volume":"22","author":"Zhang","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111308","article-title":"AdipoRon attenuates depression-like behavior in T2DM mice via inhibiting inflammation and regulating autophagy","volume":"224","author":"Zhao","year":"2025","journal-title":"Brain Res. Bull."},{"key":"B60","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41401-022-00943-1","article-title":"Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function","volume":"44","author":"Zhou","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"B61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jpsychires.2018.06.010","article-title":"NT-proBNP is a potential mediator between reduced ejection fraction and depression in patients with heart failure","volume":"104","author":"Zuzarte","year":"2018","journal-title":"J. Psychiatr. Res."}],"container-title":["Frontiers in Physiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1835186\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:22:17Z","timestamp":1790050937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphys.2026.1835186\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":61,"alternative-id":["10.3389\/fphys.2026.1835186"],"URL":"https:\/\/doi.org\/10.3389\/fphys.2026.1835186","relation":{},"ISSN":["1664-042X"],"issn-type":[{"value":"1664-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"article-number":"1835186"}}