{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:04:53Z","timestamp":1783919093707,"version":"3.55.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy (HDP) are among the leading causes of maternal and perinatal morbidity and mortality worldwide, particularly in low and middle-income countries. In Colombia, HDP complicate 13% of pregnancies and represent a major public health concern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine the incidence of HDP and characterize the longitudinal pattern of anthropometric, hemodynamic, and urinary variables in a cohort of Colombian pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was conducted including 169 pregnant women with repeated measurements of anthropometric, clinical, and urinary parameters throughout pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall incidence of HDP was 17.8 per 100 pregnancies. Women who developed HDP delivered at a lower mean gestational age (37.3 weeks). Birth weight did not differ between groups, and neonatal length was shorter in the HDP group (median 49\u00a0cm). From early pregnancy onward, women who developed gestational hypertension had significantly higher systolic, diastolic, and mean arterial pressures (p &amp;lt; 0.05) compared with normotensive women. No significant differences were observed in the evolution of body mass index (BMI) trajectories or urinary biochemical markers. However, women with gestational hypertension showed a late increase in the protein\/creatinine ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests subgroups of women at elevated risk for HDP in Colombia. Although these data are not fully translatable to clinical practice, they give insights into feasible preventative efforts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1856926","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:23:41Z","timestamp":1783916621000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertensive disorders of pregnancy: incidence, anthropometric, hemodynamic, and urinary trajectories in a Colombian cohort"],"prefix":"10.3389","volume":"17","author":[{"given":"Alejandra Mar\u00eda","family":"G\u00f3mez-Guti\u00e9rrez","sequence":"first","affiliation":[{"name":"Grupo Reproducci\u00f3n, Departamento de Fisiolog\u00eda y Bioqu\u00edmica, Facultad de Medicina, Universidad de Antioquia (UdeA)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Arnulfo","family":"Vel\u00e1squez-Penagos","sequence":"additional","affiliation":[{"name":"Grupo Nacer: Salud Sexual y Reproductiva, Departamento de Ginecolog\u00eda y Obstetricia, Facultad de Medicina, Universidad de Antioquia (UdeA)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Felipe","family":"Higuita-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Cooperativa de Colombia (UCC)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elkin","family":"Galeano","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Sustancias Bioactivas (GISB), Facultad de Ciencias Farmac\u00e9uticas y Alimentarias, Universidad de Antioquia (UdeA)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana C.","family":"Restrepo-Espinosa","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Sustancias Bioactivas (GISB), Facultad de Ciencias Farmac\u00e9uticas y Alimentarias, Universidad de Antioquia (UdeA)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison","family":"Osorio","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Sustancias Bioactivas (GISB), Facultad de Ciencias Farmac\u00e9uticas y Alimentarias, Universidad de Antioquia (UdeA)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Quintana-Castillo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Cooperativa de Colombia (UCC)","place":["Medell\u00edn, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C\u00e9sar","family":"Bueno-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Grupo Reproducci\u00f3n, Departamento de Fisiolog\u00eda y Bioqu\u00edmica, Facultad de Medicina, Universidad de Antioquia (UdeA)","place":["Medell\u00edn, Colombia"]},{"name":"Red Iberoamericana de Alteraciones Vasculares en Trastornos del Embarazo (RIVATREM)","place":["Chillan, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational hypertension and preeclampsia. 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