{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:30Z","timestamp":1785732390629,"version":"3.56.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Succinate is a circulating metabolic intermediate and signaling metabolite associated with several physiological and immunometabolic processes. However, whether circulating succinate relates to resting cardiovascular physiology in humans remains poorly understood. Therefore, we examined the association between fasting plasma succinate concentrations and resting heart rate (HR) and heart rate variability (HRV) parameters in young sedentary adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 85 sedentary young adults (18\u201325 years; 56 women) from the ACTIBATE study cohort (NCT02365129). Plasma succinate was measured enzymatically under fasting conditions. Resting heart rate (HR) and heart rate variability (HRV), non-invasive markers of autonomic function, were measured in fasting, thermoneutral conditions using the Polar RS800CX system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher fasting succinate concentrations showed a modest positive association with resting HR (\u03b2=0.213; R\u00b2=0.074; P\u00a0=\u00a00.046), independent of sex and BMI. In exploratory sex-stratified analyses, the association remained significant in men (\u03b2=0.379; R\u00b2=0.200; P\u00a0=\u00a00.034) but not in women (\u03b2=0.112; R\u00b2 =\u20130.024; P\u00a0=\u00a00.417), although no significant Succinate \u00d7 Sex interaction was detected. Participants with succinate levels above the cohort median showed a higher resting HR (+4 bpm; 95% CI: +0.1 to +8.3; P\u00a0=\u00a00.045) compared with those below the median, despite comparable body composition and cardiometabolic profiles (all P\u22650.105). There was no association between levels of succinate and any HRV parameters (all P\u22650.226).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated fasting plasma succinate is associated with higher resting HR in young sedentary adults. While causality cannot be inferred, these findings suggest that circulating succinate may represent a systemic metabolic marker associated with resting cardiovascular physiology in young adults. Longitudinal and mechanistic studies are warranted to clarify the physiological relevance and directionality of these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1860592","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:26:20Z","timestamp":1785731180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased fasting plasma succinate levels are associated with higher resting heart rate in young sedentary adults"],"prefix":"10.3389","volume":"17","author":[{"given":"Francisco J.","family":"Osuna-Prieto","sequence":"first","affiliation":[{"name":"Hospital Universitari Joan XXIII de Tarragona, Institut de Recerca Biom\u00e8dica Catalunya Sud (IRB CatSud)","place":["Tarragona, Spain"]},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M. A.","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Department of Education, Faculty of Education Sciences, University of Almer\u00eda","place":["Almer\u00eda, Spain"]},{"name":"SPORT Research Group (CTS-1024), CIBIS (Centro de Investigaci\u00f3n para el Bienestar y la Inclusi\u00f3n Social) Research Center, University of Almer\u00eda","place":["Almer\u00eda, Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Plaza-Florido","sequence":"additional","affiliation":[{"name":"Research Center for Exercise Medicine and Sleep\/Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine","place":["Irvine, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Vendrell","sequence":"additional","affiliation":[{"name":"Hospital Universitari Joan XXIII de Tarragona, Institut de Recerca Biom\u00e8dica Catalunya Sud (IRB CatSud)","place":["Tarragona, Spain"]},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]},{"name":"Universitat Rovira i Virgili (URV)","place":["Reus, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Fern\u00e1ndez-Veledo","sequence":"additional","affiliation":[{"name":"Hospital Universitari Joan XXIII de Tarragona, Institut de Recerca Biom\u00e8dica Catalunya Sud (IRB CatSud)","place":["Tarragona, Spain"]},{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]},{"name":"Universitat Rovira i Virgili (URV)","place":["Reus, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan R.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III","place":["Madrid, Spain"]},{"name":"Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada","place":["Granada, Spain"]},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (Ibs)","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020325","article-title":"Impact of using different levels of threshold-based artefact correction on the quantification of heart rate variability in three independent human cohorts","volume":"9","author":"Alcantara","year":"2020","journal-title":"J. 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