{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:19:14Z","timestamp":1791656354364,"version":"4.3.4"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["THINKINAZUL\/2021\/024"],"award-info":[{"award-number":["THINKINAZUL\/2021\/024"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["THINKINAZUL\/2021\/024"],"award-info":[{"award-number":["THINKINAZUL\/2021\/024"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Physiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Mediterranean Sea is warming approximately 20% faster than the global average, underscoring the urgent need for adaptive aquaculture strategies, including the evaluation of novel feed formulations under environmentally relevant conditions. To address this objective, the present study assessed the performance of gilthead sea bream during the unusually warm summers recently recorded in the Western Mediterranean, where temperatures have increased by approximately 0.1\u00a0\u00b0C per year over the past decade. The rising temperatures between 2020 and 2025 were associated with progressively shorter production cycles, particularly in the 2022 cohort, where growth rates increased by approximately 10-15%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cohort, we conducted a ten\u2212month trial (May 2022\u2013February 2023) to evaluate juvenile performance using a plant\u2212based diet representative of current commercial formulations, along with two experimental diets in which fishmeal and fish oil were partially replaced by either processed animal proteins and salmon oil by\u2212products (PAP diet) or a combination of insect proteins, microbial biomass, and algal oil (ALT diet).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Growth performance remained largely comparable across dietary treatments, and histological analyses of liver and anterior\/posterior intestine at three sampling points (July, November, February) revealed no tissue alterations, indicating preserved organ integrity throughout the trial. Despite similar growth outcomes, fish relied on distinct physiological strategies to sustain performance. The ALT diet was associated with reduced basal stress\u2212axis activity, more proactive behavioral responses following confinement, and enhanced intestinal transcriptional activity, suggesting improved physiological responses to aquaculture stressors. Conversely, the PAP diet was associated with a down-regulation of liver and white muscle transcriptomes, which may indicate a potential trade\u2212off that could affect cold\u2212adaptation capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, these findings suggest that alternative and low\u2212trophic feed ingredients following circular economy principles can sustain growth and tissue health even under atypically warm conditions, while also modulating stress\u00a0physiology in ways that may enhance robustness in a rapidly warming Mediterranean. By identifying diet\u2212specific physiological signatures, this study provides actionable insights for the design of aquafeeds better adapted to warming conditions, supporting the transition toward more sustainable and adaptive aquaculture systems, particularly in the Mediterranean region, where accelerating warming demands rapid innovation to maintain productivity, animal welfare, and long-term sector sustainability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphys.2026.1860904","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:24:53Z","timestamp":1782793493000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Physiologically mediated responses in gilthead sea bream (Sparus aurata) fed sustainable diets: seasonal growth under warming conditions"],"prefix":"10.3389","volume":"17","author":[{"given":"Paul George","family":"Holhorea","sequence":"first","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Moroni","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Estensoro","sequence":"additional","affiliation":[{"name":"Pathology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Belenguer","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Domingo-Bret\u00f3n","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Naya-Catal\u00e0","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Calduch-Giner","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Integrative Fish Biology Group, Institute of Aquaculture Torre de la Sal (IATS, CSIC)","place":["Castell\u00f3n, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10695-025-01470-6","article-title":"Influences of thermal stress on the growth biometrics, stress indicators, oxidative stress biomarkers, and histopathological alterations in European seabass (Dicentrarchus labrax) juveniles","volume":"51","author":"Abdel-Tawwab","year":"2025","journal-title":"Fish Physiol. 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